The Resveratrol Tetramer r-Viniferin Induces a Cell Cycle Arrest Followed by Apoptosis in the Prostate Cancer Cell Line LNCaP

2015 ◽  
Vol 29 (10) ◽  
pp. 1640-1645 ◽  
Author(s):  
Michael T. Empl ◽  
Malena Albers ◽  
Shan Wang ◽  
Pablo Steinberg
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Cycle Arrest ◽  
A Cell

Garlic Compound, Diallyl Disulfide Induces Cell Cycle Arrest in Prostate Cancer Cell Line PC-3

2006 ◽  
Vol 288 (1-2) ◽  
pp. 107-113 ◽  
Author(s):  
Arumugam Arunkumar ◽  
Marati Radhakrishnan Vijayababu ◽  
Narasimman Srinivasan ◽  
Maria Michael Aruldhas ◽  
Jagedeesan Arunakaran
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Diallyl Disulfide ◽  
Cycle Arrest

Cell cycle perturbations and radiosensitization effects in a human prostate cancer cell line

2003 ◽  
Vol 129 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Albert A. Geldof ◽  
Marian A.B.D. Plaizier ◽  
Ilse Duivenvoorden ◽  
Marieke Ringelberg ◽  
Richard T. Versteegh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell

scholarly journals Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line

FEBS Letters ◽  
2004 ◽  
Vol 577 (1-2) ◽  
pp. 55-59 ◽  
Author(s):  
Teruki Oki ◽  
Yoshihiro Sowa ◽  
Tohru Hirose ◽  
Nobumasa Takagaki ◽  
Mano Horinaka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Line ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Human Prostate Cancer ◽  
M Cell ◽  
Human Prostate Cancer Cell ◽  
Cycle Arrest

scholarly journals Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes

2004 ◽  
Vol 11 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Hari Krishnan Nair ◽  
Kesava V. K. Rao ◽  
Ravikumar Aalinkeel ◽  
Supriya Mahajan ◽  
Ram Chawda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Line ◽  
Cancer Cell ◽  
Tumor Suppressor Genes ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Suppressor Genes

ABSTRACT The natural product quercetin is a flavonoid found in many fruits and vegetables. Previous research has shown that quercetin has antitumor, anti-inflammatory, antiallergic, and antiviral activities. In the present investigation we studied the effect of quercetin on the ability of prostate cancer cell lines with various degrees of aggressive potential to form colonies in vitro. Specifically, we examined the molecular mechanisms underlying this effect, including the expression of cell cycle and tumor suppressor genes as well as oncogenes. We observed that quercetin at concentrations of 25 and 50 μM significantly inhibited the growth of the highly aggressive PC-3 prostate cancer cell line and the moderately aggressive DU-145 prostate cancer cell line, whereas it did not affect colony formation by the poorly aggressive LNCaP prostate cancer cell line or the normal fibroblast cell line BG-9. Using the gene array methodology, we found that quercetin significantly inhibited the expression of specific oncogenes and genes controlling G1, S, G2, and M phases of the cell cycle. Moreover, quercetin reciprocally up-regulated the expression of several tumor suppressor genes. In conclusion, our results demonstrate that the antitumor effects of quercetin directly correlate with the aggressive potential of prostate cancer cells and that the mechanism(s) of quercetin-mediated antitumor effects may involve up-regulation of tumor suppressor genes and reciprocal down-regulation of oncogenes and cell cycle genes. The results of these studies provide a scientific basis for the potential use of flavonoids as nutraceuticals in the chemoprevention of cancer.

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