β‐Elemene inhibits peritoneal metastasis of gastric cancer cells by modulating FAK/Claudin‐1 signaling

2019 ◽  
Vol 33 (9) ◽  
pp. 2448-2456 ◽  
Author(s):  
Mingming Deng ◽  
Ye Zhang ◽  
Bofang Liu ◽  
Yang Chen ◽  
Huicong Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Gastric Cancer Cells

scholarly journals A self-enforcing HOXA11/Stat3 feedback loop promotes stemness properties and peritoneal metastasis in gastric cancer cells

Theranostics ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 7628-7647 ◽  
Author(s):  
Chao Wang ◽  
Min Shi ◽  
Jun Ji ◽  
Qu Cai ◽  
Jinling Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Feedback Loop ◽  
Gastric Cancer Cells

scholarly journals Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression

2016 ◽  
Vol 35 (5) ◽  
pp. 2624-2634 ◽  
Author(s):  
YUANYI XU ◽  
XIU JIN ◽  
YUNNING HUANG ◽  
JIANDA DONG ◽  
HONGHONG WANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Human Gastric Cancer ◽  
Dextran Sulphate ◽  
Gastric Cancer Cells

scholarly journals Inhibition of the peritoneal metastasis of human gastric cancer cells by dextran sulphate in vivo and in vitro

2016 ◽  
Vol 11 (4) ◽  
pp. 2384-2390 ◽  
Author(s):  
YUANYI XU ◽  
YUNNING HUANG ◽  
HONGHONG WANG ◽  
YONG LIU
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Human Gastric Cancer ◽  
Dextran Sulphate ◽  
Gastric Cancer Cells

scholarly journals Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model

2012 ◽  
Vol 27 (9) ◽  
pp. 1037 ◽  
Author(s):  
Mi Ra Park ◽  
Ji Hee Lee ◽  
Myung Suk Park ◽  
Jun Eul Hwang ◽  
Hyun Jeong Shim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Suppressive Effect ◽  
Gastric Cancer Cells ◽  
Metastasis Model

scholarly journals LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target

Oncogene ◽  
2021 ◽  
Author(s):  
Xi Kang ◽  
Weilin Li ◽  
Weixin Liu ◽  
Han Liang ◽  
Jingyu Deng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Therapeutic Target ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Cell Migration And Invasion

AbstractPeritoneal metastasis is a common form of metastasis among advanced gastric cancer patients. In this study, we reported the identification of LIM domain kinase 1 (LIMK1) as a promoter of gastric cancer peritoneal metastasis, and its potential to be a therapeutic target of dabrafenib (DAB). Using transcriptomic sequencing of paired gastric cancer peritoneal metastasis, primary tumors, and normal gastric tissues, we first unveiled that LIMK1 is selectively up-regulated in metastatic tumors. Increased LIMK1 in gastric cancer peritoneal metastasis was validated by immunohistochemistry analysis of an independent patient cohort. In vitro functional studies demonstrated that LIMK1 knockout or knockdown significantly inhibited cell migration and invasion of gastric cancer cells. LIMK1 knockout also abrogated peritoneal and liver metastases of gastric cancer cells in nude mice in vivo. Dabrafenib, a small molecule targeting LIMK1, was found to decrease cell migration and invasion of gastric cancer cells in vitro and abolish peritoneal and liver metastasis formation in vivo. Mechanistically, either LIMK1 knockout or Dabrafenib inhibited LIMK1 expression and phosphorylation of its downstream target cofilin. Taken together, our results demonstrated that LIMK1 functions as a metastasis promoter in gastric cancer by inhibiting LIMK1-p-cofilin and that Dabrafenib has the potential to serve as a novel treatment for gastric cancer peritoneal metastasis.

Prevention of Peritoneal Metastasis of Human Gastric Cancer Cells in Nude Mice by S-1, a Novel Oral Derivative of 5-Fluorouracil

Oncology ◽  
2003 ◽  
Vol 64 (2) ◽  
pp. 176-182 ◽  
Author(s):  
Takuji Mori ◽  
Yoshiyuki Fujiwara ◽  
Masahiko Yano ◽  
Shigeyuki Tamura ◽  
Takushi Yasuda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Peritoneal Metastasis ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells
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