scholarly journals Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model

2012 ◽  
Vol 27 (9) ◽  
pp. 1037 ◽  
Author(s):  
Mi Ra Park ◽  
Ji Hee Lee ◽  
Myung Suk Park ◽  
Jun Eul Hwang ◽  
Hyun Jeong Shim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Suppressive Effect ◽  
Gastric Cancer Cells ◽  
Metastasis Model

scholarly journals MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2

2009 ◽  
Vol 20 (24) ◽  
pp. 5127-5137 ◽  
Author(s):  
Kai-Wen Hsu ◽  
Rong-Hong Hsieh ◽  
Chew-Wun Wu ◽  
Chin-Wen Chi ◽  
Yan-Hwa Wu Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Suppressive Effect ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition ◽  
Cox 2

The c-Myc promoter binding protein 1 (MBP-1) is a transcriptional suppressor of c-myc expression and involved in control of tumorigenesis. Gastric cancer is one of the most frequent neoplasms and lethal malignancies worldwide. So far, the regulatory mechanism of its aggressiveness has not been clearly characterized. Here we studied roles of MBP-1 in gastric cancer progression. We found that cell proliferation was inhibited by MBP-1 overexpression in human stomach adenocarcinoma SC-M1 cells. Colony formation, migration, and invasion abilities of SC-M1 cells were suppressed by MBP-1 overexpression but promoted by MBP-1 knockdown. Furthermore, the xenografted tumor growth of SC-M1 cells was suppressed by MBP-1 overexpression. Metastasis in lungs of mice was inhibited by MBP-1 after tail vein injection with SC-M1 cells. MBP-1 also suppressed epithelial-mesenchymal transition in SC-M1 cells. Additionally, MBP-1 bound on cyclooxygenase 2 (COX-2) promoter and downregulated COX-2 expression. The MBP-1-suppressed tumor progression in SC-M1 cells were through inhibition of COX-2 expression. MBP-1 also exerted a suppressive effect on tumor progression of other gastric cancer cells such as AGS and NUGC-3 cells. Taken together, these results suggest that MBP-1–suppressed COX-2 expression plays an important role in the inhibition of growth and progression of gastric cancer.

scholarly journals A self-enforcing HOXA11/Stat3 feedback loop promotes stemness properties and peritoneal metastasis in gastric cancer cells

Theranostics ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 7628-7647 ◽  
Author(s):  
Chao Wang ◽  
Min Shi ◽  
Jun Ji ◽  
Qu Cai ◽  
Jinling Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Feedback Loop ◽  
Gastric Cancer Cells

scholarly journals Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression

2016 ◽  
Vol 35 (5) ◽  
pp. 2624-2634 ◽  
Author(s):  
YUANYI XU ◽  
XIU JIN ◽  
YUNNING HUANG ◽  
JIANDA DONG ◽  
HONGHONG WANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Human Gastric Cancer ◽  
Dextran Sulphate ◽  
Gastric Cancer Cells

Suppressive effect of bevacizumab on peritoneal dissemination from gastric cancer in a peritoneal metastasis model

Surgery Today ◽  
2010 ◽  
Vol 40 (9) ◽  
pp. 851-857 ◽  
Author(s):  
Takuya Imaizumi ◽  
Keishiro Aoyagi ◽  
Motoshi Miyagi ◽  
Kazuo Shirouzu
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Metastasis ◽  
Peritoneal Dissemination ◽  
Suppressive Effect ◽  
Metastasis Model

scholarly journals Inhibition of the peritoneal metastasis of human gastric cancer cells by dextran sulphate in vivo and in vitro

2016 ◽  
Vol 11 (4) ◽  
pp. 2384-2390 ◽  
Author(s):  
YUANYI XU ◽  
YUNNING HUANG ◽  
HONGHONG WANG ◽  
YONG LIU
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Human Gastric Cancer ◽  
Dextran Sulphate ◽  
Gastric Cancer Cells

β‐Elemene inhibits peritoneal metastasis of gastric cancer cells by modulating FAK/Claudin‐1 signaling

2019 ◽  
Vol 33 (9) ◽  
pp. 2448-2456 ◽  
Author(s):  
Mingming Deng ◽  
Ye Zhang ◽  
Bofang Liu ◽  
Yang Chen ◽  
Huicong Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Metastasis ◽  
Gastric Cancer Cells
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