Elective lower limb orthopaedic arthroplasty surgery in patients with pulmonary hypertension

Introduction Currently there are no consensuses in the national guidance on thromboprophylaxis following major elective lower limb surgery. Emerging clinical evidence suggests that aspirin could be just as effective as anticoagulants with a lower cost. The aim of this study was to provide an update based on literature of the past 3 years for the use of aspirin as thromboprophylaxis after knee and hip arthroplasty. Materials and Methods MEDLINE/EMBASE search was performed with appropriate terms for original articles from 2014 to 2017. Results Eight articles were found. Five articles concluded that aspirin was an effective prophylactic. The collation of results on the deep vein thrombosis rate involved 43,012 patients who were prescribed aspirin, of which 283 (0.66%) suffered from symptomatic deep vein thromboses. Aspirin was noted for its good side effect profile and cost effectiveness. It was noted that anticoagulants had a higher rate of complications, including bleeding and wound-oozing. Conclusion Aspirin is an effective and safe prophylactic against deep vein thrombosis following major elective lower limb arthroplasty surgery.

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Thromboprophylaxis in lower limb arthroplasty surgery: A review

Current Orthopaedics ◽

10.1016/s0268-0890(97)90046-3 ◽

1997 ◽

Vol 11 (1) ◽

pp. 19-23

Author(s):

H.R Williams ◽

D.A Macdonald

Keyword(s):

Lower Limb ◽

Arthroplasty Surgery

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Ischemia and reperfusion injury: prevention of pulmonary hypertension and leukosequestration following lower limb ischemia

Prostaglandins Leukotrienes and Essential Fatty Acids ◽

10.1016/s0952-3278(97)90507-x ◽

1997 ◽

Vol 56 (2) ◽

pp. 117-120 ◽

Cited By ~ 4

Author(s):

U. Bengisun ◽

C. Köksoy ◽

J.S. Bengisun ◽

G. Bayraktaroğlu ◽

A. Çamur ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Reperfusion Injury ◽

Injury Prevention ◽

Lower Limb ◽

Limb Ischemia ◽

Ischemia And Reperfusion ◽

Ischemia And Reperfusion Injury ◽

Lower Limb Ischemia

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Reversible Pulmonary Hypertension Secondary to Scurvy in a Patient with a Psychiatric Disorder: a Case Report and Literature Review

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_001404 ◽

2020 ◽

Author(s):

Carolina Cavalcanti Gonçalves Ferreira ◽

Deborah de Sá Pereira Belfort ◽

Paulo Miranda Cavalcante Neto ◽

Pedro Alves da Cruz Gouveia

Keyword(s):

Pulmonary Hypertension ◽

Ascorbic Acid ◽

Lower Limb ◽

Systolic Pressure ◽

Pulmonary Artery Systolic Pressure ◽

Connective Tissue Disorders ◽

Ascorbic Acid Deficiency ◽

Paranoid Personality Disorder ◽

Paranoid Personality ◽

Acid Deficiency

Pulmonary hypertension (PH) can be related to several diseases, such as connective tissue disorders and pulmonary embolism, or to drugs; it may also be idiopathic. Few cases have been reported demonstrating an association between ascorbic acid deficiency and reversible PH. We report the case of a patient who arrived at the emergency department with dyspnoea, tachycardia and lower limb perifollicular haemorrhage. Examinations, including a transthoracic echocardiogram, revealed enlarged right chambers and an estimated pulmonary artery systolic pressure of 61 mmHg. Further evaluation revealed poor food intake due to paranoid personality disorder, leading to ascorbic acid deficiency and manifestations of scurvy.

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