The innate immune response in Zika virus infection

2020 ◽  
Author(s):  
Jorge Rodrigues de Sousa ◽  
Raimunda do Socorro da Silva Azevedo ◽  
Juarez Antônio Simões Quaresma ◽  
Pedro Fernando da Costa Vasconcelos
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Zika Virus ◽  
Innate Immune ◽  
Zika Virus Infection

Innate immune response in patients with acute Zika virus infection

2019 ◽  
Vol 208 (6) ◽  
pp. 703-714 ◽  
Author(s):  
Marcelo Henrique Matias da Silva ◽  
Raiza Nara Cunha Moises ◽  
Brenda Elen Bizerra Alves ◽  
Hannaly Wana Bezerra Pereira ◽  
Anne Aline Pereira de Paiva ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Zika Virus ◽  
Innate Immune ◽  
Zika Virus Infection

The innate immune response during Zika virus infection

2021 ◽  
pp. 19-29
Author(s):  
Manuela Sales Lima Nascimento ◽  
Wilo Victor dos Santos ◽  
Amanda Costa Ayres Salmeron ◽  
Josélio Maria Galvão de Araújo ◽  
José Veríssimo Fernandes ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Zika Virus ◽  
Innate Immune ◽  
Zika Virus Infection

scholarly journals Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1

2017 ◽  
Vol 91 (21) ◽  
Author(s):  
Promisree Choudhury ◽  
Luke D. Bussiere ◽  
Cathy L. Miller
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Nonstructural Protein ◽  
Innate Immune ◽  
Common Mechanism ◽  
Effector Protein ◽  
Associated Proteins ◽  
Mammalian Orthoreovirus ◽  
Late Stages

ABSTRACT Mammalian orthoreovirus (MRV) infection induces phosphorylation of translation initiation factor eIF2α, which promotes the formation of discrete cytoplasmic inclusions, termed stress granules (SGs). SGs are emerging as a component of the innate immune response to virus infection, and modulation of SG assembly is a common mechanism employed by viruses to counter this antiviral response. We previously showed that MRV infection induces SGs early and then interferes with SG formation as infection proceeds. In this work, we found that SG-associated proteins localized to the periphery of virus-encoded cytoplasmic structures, termed virus factories (VFs), where viral transcription, translation, and replication occur. The localization of SG proteins to VFs was dependent on polysome dissociation and occurred via association of the SG effector protein, Ras-GAP SH3-binding protein 1 (G3BP1), with the MRV nonstructural protein σNS, which localizes to VFs via association with VF nucleating protein, μNS. Deletion analysis of the σNS RNA binding domain and G3BP1 RNA (RRM) and ribosomal (RGG) binding domains showed that σNS association and VF localization phenotypes of G3BP1 do not occur solely through RNA or ribosomal binding but require both the RRM and RGG domains of G3BP1 for maximal viral-factory-like structure (VFL) localization and σNS association. Coexpression of σNS and μNS resulted in disruption of normal SG puncta, and in cells lacking G3BP1, MRV replication was enhanced in a manner correlating with strain-dependent induction of host translation shutoff. These results suggest that σNS association with G3BP1 and relocalization of G3BP1 to the VF periphery play roles in SG disruption to facilitate MRV replication in the host translational shutoff environment. IMPORTANCE SGs and SG effector proteins have emerged as important, yet poorly understood, players in the host's innate immune response to virus infection. MRV infection induces SGs early during infection that are dispersed and/or prevented from forming during late stages of infection despite continued activation of the eIF2α signaling pathway. Cellular and viral components involved in disruption of SGs during late stages of MRV infection remain to be elucidated. This work provides evidence that MRV disruption of SGs may be facilitated by association of the MRV nonstructural protein σNS with the major SG effector protein G3BP1 and subsequent localization of G3BP1 and other SG-associated proteins around the peripheries of virus-encoded factories, interrupting the normal formation of SGs. Our findings also reveal the importance of G3BP1 as an inhibitor of MRV replication during infection for the first time.

scholarly journals Evolution of the innate and adaptive immune response in women with acute Zika virus infection

2019 ◽  
Vol 5 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Pierre Tonnerre ◽  
Juliana G. Melgaço ◽  
Almudena Torres-Cornejo ◽  
Marcelo A. Pinto ◽  
Constanze Yue ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Zika Virus ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Zika Virus Infection

scholarly journals Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways

2016 ◽  
Vol 47 (1) ◽  
Author(s):  
Shilong Chen ◽  
Guifeng Luo ◽  
Zhou Yang ◽  
Shuncheng Lin ◽  
Shaoying Chen ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Signaling Pathways ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Host Innate Immune Response ◽  
Tembusu Virus

scholarly journals STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection

2012 ◽  
Vol 2 (1) ◽  
Author(s):  
Arshed Nazmi ◽  
Rupanjan Mukhopadhyay ◽  
Kallol Dutta ◽  
Anirban Basu
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Japanese Encephalitis Virus ◽  
Innate Immune Response ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Innate Immune ◽  
Japanese Encephalitis Virus Infection

scholarly journals Zika Virus–Infected Decidual Cells Elicit a Gestational Age–Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission

2020 ◽  
Vol 205 (11) ◽  
pp. 3083-3094
Author(s):  
Ozlem Guzeloglu-Kayisli ◽  
Xiaofang Guo ◽  
Zhonghua Tang ◽  
Nihan Semerci ◽  
Asli Ozmen ◽  
...  
Keyword(s):  
Immune Response ◽  
Vertical Transmission ◽  
Innate Immune Response ◽  
Gestational Age ◽  
Zika Virus ◽  
Innate Immune ◽  
Decidual Cells ◽  
Age Dependent

scholarly journals Innate immune response to encephalomyocarditis virus infection mediated by CD1d

Immunology ◽  
2003 ◽  
Vol 110 (4) ◽  
pp. 519-526 ◽  
Author(s):  
Mark A. Exley ◽  
Nancy J. Bigley ◽  
Olivia Cheng ◽  
Angela Shaulov ◽  
Syed Muhammad Ali Tahir ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Encephalomyocarditis Virus
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