scholarly journals Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy

2012 ◽  
Vol 31 (17) ◽  
pp. 1887-1902 ◽  
Author(s):  
Daniel Almirall ◽  
Scott N. Compton ◽  
Meredith Gunlicks-Stoessel ◽  
Naihua Duan ◽  
Susan A. Murphy
Keyword(s):  
Randomized Trial ◽  
Treatment Strategy ◽  
Adaptive Treatment ◽  
Multiple Assignment ◽  
Adaptive Treatment Strategy

scholarly journals SMARTAR: an R package for designing and analyzing Sequential Multiple Assignment Randomized Trials

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10559
Author(s):  
Xiaobo Zhong ◽  
Bin Cheng ◽  
Xinru Wang ◽  
Ying Kuen Cheung
Keyword(s):  
Randomized Trial ◽  
Treatment Strategies ◽  
Secondary Data ◽  
Real Data ◽  
R Package ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategies ◽  
Chronic Disorder ◽  
Multiple Assignment ◽  
Adaptive Treatment Strategy

This article introduces an R package, SMARTAR (Sequential Multiple Assignment Randomized Trial with Adaptive Randomization), by which clinical investigators can design and analyze a sequential multiple assignment randomized trial (SMART) for comparing adaptive treatment strategies. Adaptive treatment strategies are commonly used in clinical practice to personalize healthcare in chronic disorder management. SMART is an efficient clinical design for selecting the best adaptive treatment strategy from a family of candidates. Although some R packages can help in adaptive treatment strategies research, they mainly focus on secondary data analysis for observational studies, instead of clinical trials. SMARTAR is the first R package provides functions that can support clinical investigators and data analysts at every step of the statistical work pipeline in clinical trial practice. In this article, we demonstrate how to use this package, using a real data example.

Evaluation of Tumor Response and an Adaptive Treatment Strategy in Lung Radiotherapy using Cone-beam CT

2008 ◽  
Vol 72 (1) ◽  
pp. S604
Author(s):  
T.P. Wong ◽  
K. McCune ◽  
J. Ye ◽  
D. Cao ◽  
M. Afghan ◽  
...  
Keyword(s):  
Treatment Strategy ◽  
Tumor Response ◽  
Cone Beam Ct ◽  
Cone Beam ◽  
Adaptive Treatment ◽  
Lung Radiotherapy ◽  
Adaptive Treatment Strategy

scholarly journals SMARTer Discontinuation Trial Designs for Developing an Adaptive Treatment Strategy

2012 ◽  
Vol 22 (5) ◽  
pp. 364-374 ◽  
Author(s):  
Daniel Almirall ◽  
Scott N. Compton ◽  
Moira A. Rynn ◽  
John T. Walkup ◽  
Susan A. Murphy
Keyword(s):  
Treatment Strategy ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategy

Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial

2018 ◽  
Vol 58 ◽  
pp. 42-50 ◽  
Author(s):  
Daniel Fatori ◽  
Carlos Alberto de Bragança Pereira ◽  
Fernando R. Asbahr ◽  
Guaraci Requena ◽  
Pedro G. Alvarenga ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Treatment Strategies ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategies ◽  
Multiple Assignment

scholarly journals Developing Adaptive Treatment Strategies to Address Suicidal Risk in College Students: A Pilot Sequential, Multiple Assignment, Randomized Trial (SMART)

2018 ◽  
Vol 22 (4) ◽  
pp. 644-664 ◽  
Author(s):  
Jacqueline Pistorello ◽  
David A. Jobes ◽  
Scott N. Compton ◽  
Nadia Samad Locey ◽  
Joseph C. Walloch ◽  
...  
Keyword(s):  
College Students ◽  
Randomized Trial ◽  
Treatment Strategies ◽  
Suicidal Risk ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategies ◽  
Multiple Assignment

scholarly journals Stepping through treatment: Reflections on an adaptive treatment strategy among methamphetamine users with depression

2010 ◽  
Vol 29 (5) ◽  
pp. 475-482 ◽  
Author(s):  
FRANCES J. KAY-LAMBKIN ◽  
AMANDA L. BAKER ◽  
REBECCA MCKETIN ◽  
NICOLE LEE
Keyword(s):  
Treatment Strategy ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategy

25.4 AN ADAPTIVE TREATMENT STRATEGY FOR ADOLESCENT DEPRESSION: BEGINNING WITH NBSP; INTERPERSONAL PSYCHOTHERAPY FOR DEPRESSED ADOLESCENTS

2016 ◽  
Vol 55 (10) ◽  
pp. S39
Author(s):  
Meredith Gunlicks-Stoessel ◽  
Laura Mufson ◽  
Ana Westervelt ◽  
Daniel Almirall ◽  
Susan Murphy
Keyword(s):  
Treatment Strategy ◽  
Adolescent Depression ◽  
Interpersonal Psychotherapy ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategy

scholarly journals Proof of Concept for an Adaptive Treatment Strategy to Prevent Failures in Internet-Delivered CBT: A Single-Blind Randomized Clinical Trial With Insomnia Patients

2019 ◽  
Vol 176 (4) ◽  
pp. 315-323 ◽  
Author(s):  
Erik Forsell ◽  
Susanna Jernelöv ◽  
Kerstin Blom ◽  
Martin Kraepelien ◽  
Cecilia Svanborg ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Treatment Strategy ◽  
Proof Of Concept ◽  
Adaptive Treatment ◽  
Adaptive Treatment Strategy ◽  
Single Blind
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