scholarly journals CD13 Regulates Anchorage and Differentiation of the Skeletal Muscle Satellite Stem Cell Population in Ischemic Injury

Stem Cells ◽  
2014 ◽  
Vol 32 (6) ◽  
pp. 1564-1577 ◽  
Author(s):  
M. Mamunur Rahman ◽  
Mallika Ghosh ◽  
Jaganathan Subramani ◽  
Guo-Hua Fong ◽  
Morgan E. Carlson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Population ◽  
Ischemic Injury ◽  
Stem Cell Population

The alpha7beta1 Integrin Recruits a Sca-1+/CD45- Stem Cell Population In Skeletal Muscle Following Exercise-Induced Injury

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S33
Author(s):  
Marni D. Boppart ◽  
Jianming Liu ◽  
Nicole M. Alexander ◽  
Stephen J. Kaufman
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Population ◽  
Stem Cell Population ◽  
Exercise Induced ◽  
Alpha7beta1 Integrin

scholarly journals The First Characterization of a Novel Stem Cell Population and the Temporal Relationship with Satellite Cells in Human Skeletal Muscle

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Nelson Ian Saddler ◽  
Josh Nederveen ◽  
Tim Snijders ◽  
Sophie Joanisse ◽  
Jeff Baker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Population ◽  
Satellite Cells ◽  
Human Skeletal Muscle ◽  
Temporal Relationship ◽  
Stem Cell Population

scholarly journals Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell–enriched Population by Stimulating Their Differentiation

Endocrinology ◽  
2020 ◽  
Vol 161 (10) ◽  
Author(s):  
Shimeng Liu ◽  
Ping Yin ◽  
Jingting Xu ◽  
Ariel J Dotts ◽  
Stacy A Kujawa ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cell ◽  
Cell Population ◽  
Uterine Leiomyoma ◽  
Stem Cell Population ◽  
Epigenetic Landscape ◽  
Stem Cell Regulation ◽  
Integrative Analyses ◽  
Associated Functions ◽  
Intermediate Cells

Abstract Uterine leiomyoma (LM) is the most common tumor in women and can cause severe morbidity. Leiomyoma growth requires the maintenance and proliferation of a stem cell population. Dysregulated deoxyribonucleic acid (DNA) methylation has been reported in LM, but its role in LM stem cell regulation remains unclear. Here, we fluorescence-activated cell sorting (FACS)-sorted cells from human LM tissues into 3 populations: LM stem cell–like cells (LSC, 5%), LM intermediate cells (LIC, 7%), and differentiated LM cells (LDC, 88%), and we analyzed the transcriptome and epigenetic landscape of LM cells at different differentiation stages. Leiomyoma stem cell–like cells harbored a unique methylome, with 8862 differentially methylated regions compared to LIC and 9444 compared to LDC, most of which were hypermethylated. Consistent with global hypermethylation, transcript levels of TET1 and TET3 methylcytosine dioxygenases were lower in LSC. Integrative analyses revealed an inverse relationship between methylation and gene expression changes during LSC differentiation. In LSC, hypermethylation suppressed the genes important for myometrium- and LM-associated functions, including muscle contraction and hormone action, to maintain stemness. The hypomethylating drug, 5′-Aza, stimulated LSC differentiation, depleting the stem cell population and inhibiting tumor initiation. Our data suggest that DNA methylation maintains the pool of LSC, which is critical for the regeneration of LM tumors.

The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis

2017 ◽  
Vol 53 ◽  
pp. S105
Author(s):  
Alexander Gerbaulet ◽  
Kristina Schoedel ◽  
Mina Morcos ◽  
Thomas Zerjatke ◽  
Ingo Roeder ◽  
...  
Keyword(s):  
Stem Cell ◽  
Steady State ◽  
Hematopoietic Stem Cell ◽  
Cell Population ◽  
Stem Cell Population ◽  
Hematopoietic Stem

scholarly journals Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

2009 ◽  
Vol 4 (5) ◽  
pp. 427-439 ◽  
Author(s):  
Kim B. Jensen ◽  
Charlotte A. Collins ◽  
Elisabete Nascimento ◽  
David W. Tan ◽  
Michaela Frye ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Population ◽  
Stem Cell Population ◽  
Multipotent Stem Cell
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