Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling

Stem Cells ◽  
2016 ◽  
Vol 34 (11) ◽  
pp. 2635-2647 ◽  
Author(s):  
Claudia Davenport ◽  
Ulf Diekmann ◽  
Insa Budde ◽  
Nora Detering ◽  
Ortwin Naujok
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Definitive Endoderm ◽  
Bmp Signaling ◽  
Differential Signaling ◽  
Anterior Posterior

Ultrastructure of Human Embryonic Stem Cells and Spontaneous and Retinoic Acid-Induced Differentiating Cells

2004 ◽  
Vol 28 (4) ◽  
pp. 229-238 ◽  
Author(s):  
Sung-Hye Park ◽  
Seong Hoe Park ◽  
Myeong-Cherl Kook ◽  
Eun-Young Kim ◽  
Sepill Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

2010 ◽  
Vol 145 (3) ◽  
pp. 284-294 ◽  
Author(s):  
Gabriella Brolén ◽  
Louise Sivertsson ◽  
Petter Björquist ◽  
Gustav Eriksson ◽  
Monica Ek ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Definitive Endoderm

Definitive endoderm: a key step in coaxing human embryonic stem cells into transplantable β-cells

2008 ◽  
Vol 36 (3) ◽  
pp. 272-275 ◽  
Author(s):  
Henrik Semb
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Insulin Pump ◽  
Embryonic Stem ◽  
Definitive Endoderm ◽  
Attractive Alternative ◽  
Β Cells ◽  
Number Of Patients

Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be widely available, it will require an unlimited source of cells to serve as a ‘biological’ insulin pump. At this time, the development of β-cells from hESCs (human embryonic stem cells) has emerged as the most attractive alternative. It is envisioned that ultimate success of an in vitro approach to programme hESCs into β-cells will depend on the ability, at least to a certain degree, to sequentially reproduce the individual steps that characterizes normal β-cell ontogenesis during fetal pancreatic development, including definitive endoderm from which all gastrointestinal organs, including the pancreas, originate. In the present article, differentiation of hESCs into putative definitive endodermal cell types is reviewed.

sRNA-seq Analysis of Human Embryonic Stem Cells and Definitive Endoderm Reveals Differentially Expressed MicroRNAs and Novel IsomiRs with Distinct Targets

Stem Cells ◽  
2014 ◽  
Vol 32 (9) ◽  
pp. 2360-2372 ◽  
Author(s):  
Andrew Hinton ◽  
Shaun E. Hunter ◽  
Ivka Afrikanova ◽  
G. Adam Jones ◽  
Ana D. Lopez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Definitive Endoderm ◽  
Differentially Expressed

scholarly journals A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells

2012 ◽  
Vol 21 (12) ◽  
pp. 2273-2287 ◽  
Author(s):  
Pei Wang ◽  
Kristen D. McKnight ◽  
David J. Wong ◽  
Ryan T. Rodriguez ◽  
Takuya Sugiyama ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Definitive Endoderm ◽  
Molecular Signature
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