scholarly journals Essential Roles of Thyroid Hormone-Regulated Hyaluronan/CD44 Signaling in Adult Stem Cell Development During Xenopus laevis Intestinal Remodeling

Stem Cells ◽  
2017 ◽  
Vol 35 (10) ◽  
pp. 2175-2183 ◽  
Author(s):  
Takashi Hasebe ◽  
Kenta Fujimoto ◽  
Mitsuko Kajita ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Intestinal Remodeling

scholarly journals Epithelial-Connective Tissue Interactions Induced by Thyroid Hormone Receptor Are Essential for Adult Stem Cell Development in the Xenopus laevis Intestine

Stem Cells ◽  
2011 ◽  
Vol 29 (1) ◽  
pp. 154-161 ◽  
Author(s):  
Takashi Hasebe ◽  
Daniel R. Buchholz ◽  
Yun-Bo Shi ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Connective Tissue ◽  
Xenopus Laevis ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Tissue Interactions

Thyroid hormone regulation of stem cell development during intestinal remodeling

2008 ◽  
Vol 288 (1-2) ◽  
pp. 71-78 ◽  
Author(s):  
Atsuko Ishizuya-Oka ◽  
Yun-Bo Shi
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Cell Development ◽  
Hormone Regulation ◽  
Intestinal Remodeling

scholarly journals Expression Profiling of Intestinal Tissues Implicates Tissue-Specific Genes and Pathways Essential for Thyroid Hormone-Induced Adult Stem Cell Development

Endocrinology ◽  
2013 ◽  
Vol 154 (11) ◽  
pp. 4396-4407 ◽  
Author(s):  
Guihong Sun ◽  
Rachel A. Heimeier ◽  
Liezhen Fu ◽  
Takashi Hasebe ◽  
Biswajit Das ◽  
...  
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Expression Profiling ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Tissue Specific

Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis

2018 ◽  
Vol 228 (6) ◽  
pp. 267-273 ◽  
Author(s):  
Kenta Fujimoto ◽  
Takashi Hasebe ◽  
Mitsuko Kajita ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Cell Development ◽  
Intestinal Stem Cell ◽  
Hyaluronan Synthases

scholarly journals Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs

2020 ◽  
Vol 117 (7) ◽  
pp. 3603-3609 ◽  
Author(s):  
Fan Zou ◽  
Renjun Tu ◽  
Bo Duan ◽  
Zhenlin Yang ◽  
Zhaohua Ping ◽  
...  
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Germ Line ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Rna Modification ◽  
Proliferation And Differentiation ◽  
Germ Line Stem Cell ◽  
Rna Complex

5-Methylcytosine (m5C) is a RNA modification that exists in tRNAs and rRNAs and was recently found in mRNAs. Although it has been suggested to regulate diverse biological functions, whether m5C RNA modification influences adult stem cell development remains undetermined. In this study, we show that Ypsilon schachtel (YPS), a homolog of human Y box binding protein 1 (YBX1), promotes germ line stem cell (GSC) maintenance, proliferation, and differentiation in the Drosophila ovary by preferentially binding to m5C-containing RNAs. YPS is genetically demonstrated to function intrinsically for GSC maintenance, proliferation, and progeny differentiation in the Drosophila ovary, and human YBX1 can functionally replace YPS to support normal GSC development. Highly conserved cold-shock domains (CSDs) of YPS and YBX1 preferentially bind to m5C RNA in vitro. Moreover, YPS also preferentially binds to m5C-containing RNAs, including mRNAs, in germ cells. The crystal structure of the YBX1 CSD-RNA complex reveals that both hydrophobic stacking and hydrogen bonds are critical for m5C binding. Overexpression of RNA-binding–defective YPS and YBX1 proteins disrupts GSC development. Taken together, our findings show that m5C RNA modification plays an important role in adult stem cell development.

Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis

2016 ◽  
Vol 365 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Takashi Hasebe ◽  
Kenta Fujimoto ◽  
Mitsuko Kajita ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Epithelial Development ◽  
Intestinal Remodeling

scholarly journals Thyroid Hormone-Induced Activation of Notch Signaling is Required for Adult Intestinal Stem Cell Development DuringXenopus LaevisMetamorphosis

Stem Cells ◽  
2016 ◽  
Vol 35 (4) ◽  
pp. 1028-1039 ◽  
Author(s):  
Takashi Hasebe ◽  
Kenta Fujimoto ◽  
Mitsuko Kajita ◽  
Liezhen Fu ◽  
Yun-Bo Shi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Notch Signaling ◽  
Cell Development ◽  
Intestinal Stem Cell

scholarly journals Epigenetic regulation of thyroid hormone-induced adult intestinal stem cell development during anuran metamorphosis

2014 ◽  
Vol 4 (1) ◽  
pp. 73 ◽  
Author(s):  
Guihong Sun ◽  
Liezhen Fu ◽  
Yun-Bo Shi
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Epigenetic Regulation ◽  
Cell Development ◽  
Intestinal Stem Cell
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