scholarly journals High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors

Stem Cells ◽  
2010 ◽  
Vol 28 (10) ◽  
pp. 1741-1750 ◽  
Author(s):  
Jiaxi Zhou ◽  
Pei Su ◽  
Dong Li ◽  
Stephanie Tsang ◽  
Enkui Duan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Pluripotent Stem Cells ◽  
High Efficiency ◽  
Transforming Growth Factor ◽  
Human Escs ◽  
Single Chemical ◽  
Growth Factor Beta ◽  
Induced Pluripotent

Enhanced chondrogenesis differentiation of human induced pluripotent stem cells by MicroRNA-140 and transforming growth factor beta 3 (TGFβ3)

Biologicals ◽  
2018 ◽  
Vol 52 ◽  
pp. 30-36 ◽  
Author(s):  
Hossein Mahboudi ◽  
Masoud Soleimani ◽  
Seyed Ehsan Enderami ◽  
Mousa Kehtari ◽  
Abdolreza Ardeshirylajimi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Induced Pluripotent Stem Cells ◽  
Transforming Growth Factor Beta ◽  
Pluripotent Stem Cells ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Induced Pluripotent

scholarly journals Transforming growth factor beta induced, a new player in the therapeutic effect of mesenchymal stem cells

2018 ◽  
Vol 26 ◽  
pp. S38-S39
Author(s):  
M. Ruiz ◽  
K. Toupet ◽  
G. Fonteneau ◽  
M. Maumus ◽  
C. Jorgensen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Therapeutic Effect ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta

scholarly journals Chondrogenic Differentiation from Induced Pluripotent Stem Cells Using Non-Viral Minicircle Vectors

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 582 ◽  
Author(s):  
Yeri Alice Rim ◽  
Yoojun Nam ◽  
Narae Park ◽  
Hyerin Jung ◽  
Kijun Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Transforming Growth Factor Beta ◽  
Pluripotent Stem Cells ◽  
Transforming Growth Factor ◽  
Cartilage Regeneration ◽  
Bone Morphogenetic Protein 2 ◽  
Viral Gene ◽  
Morphogenetic Protein ◽  
Induced Pluripotent

Human degenerative cartilage has low regenerative potential. Chondrocyte transplantation offers a promising strategy for cartilage treatment and regeneration. Currently, chondrogenesis using human pluripotent stem cells (hiPSCs) is accomplished using human recombinant growth factors. Here, we differentiate hiPSCs into chondrogenic pellets using minicircle vectors. Minicircles are a non-viral gene delivery system that can produce growth factors without integration into the host genome. We generated minicircle vectors containing bone morphogenetic protein 2 (BMP2) and transforming growth factor beta 3 (TGFβ3) and delivered them to mesenchymal stem cell-like, hiPSC-derived outgrowth (OG) cells. Cell pellets generated using minicircle-transfected OG cells successfully differentiated into the chondrogenic lineage. The implanted minicircle-based chondrogenic pellets recovered the osteochondral defects in rat models. This work is a proof-of-concept study that describes the potential application of minicircle vectors in cartilage regeneration using hiPSCs.

Sign in / Sign up

Export Citation Format

Share Document