Glutamate agonists for treating schizophrenia have affinity for dopamine D2Highand D3 receptors

Synapse ◽  
2009 ◽  
Vol 63 (8) ◽  
pp. 705-709 ◽  
Author(s):  
Philip Seeman ◽  
Hong-Chang Guan
Keyword(s):  
D3 Receptors ◽  
Glutamate Agonists

Animal Studies Suggest D3 Receptors Offer New Target for Treatment Medications

2003 ◽  
Author(s):  
Jill Williams
Keyword(s):  
Animal Studies ◽  
D3 Receptors

Characterization of 25-hydroxyvitamin D3 receptors in cytosol and nuclear extracts from the hypercalcemic Walker carcinosarcoma 256

1984 ◽  
Vol 104 (4_Supplb) ◽  
pp. S4-S5
Author(s):  
J. MERKE ◽  
G. SMIGIELSKI ◽  
H. KITTSTEIN ◽  
E. RITZ
Keyword(s):  
D3 Receptors ◽  
Nuclear Extracts

scholarly journals Sleep Deprivation Decreases Binding of [11C]Raclopride to Dopamine D2/D3 Receptors in the Human Brain

2008 ◽  
Vol 28 (34) ◽  
pp. 8454-8461 ◽  
Author(s):  
N. D. Volkow ◽  
G.-J. Wang ◽  
F. Telang ◽  
J. S. Fowler ◽  
J. Logan ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Human Brain ◽  
D3 Receptors ◽  
Dopamine D2

scholarly journals Binding of Pramipexole to Extrastriatal Dopamine D2/D3 Receptors in the Human Brain: A Positron Emission Tomography Study Using 11C-FLB 457

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17723 ◽  
Author(s):  
Kenji Ishibashi ◽  
Kenji Ishii ◽  
Keiichi Oda ◽  
Hidehiro Mizusawa ◽  
Kiichi Ishiwata
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
D3 Receptors ◽  
Dopamine D2 ◽  
Positron Emission

Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome

2003 ◽  
Vol 117B (1) ◽  
pp. 57-60 ◽  
Author(s):  
Kazuo Mihara ◽  
Tsuyoshi Kondo ◽  
Akihito Suzuki ◽  
Norio Yasui-Furukori ◽  
Shingo Ono ◽  
...  
Keyword(s):  
Neuroleptic Malignant Syndrome ◽  
Gene Polymorphisms ◽  
D3 Receptors ◽  
Dopamine D2

Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D3 receptors

Neuroscience ◽  
2002 ◽  
Vol 112 (1) ◽  
pp. 39-49 ◽  
Author(s):  
J.D Joseph ◽  
Y.-M Wang ◽  
P.R Miles ◽  
E.A Budygin ◽  
R Picetti ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Brain Slices ◽  
D3 Receptors ◽  
Dopamine Autoreceptor

scholarly journals Visual Disfunction due to the Selective Effect of Glutamate Agonists on Retinal Cells

2021 ◽  
Vol 22 (12) ◽  
pp. 6245
Author(s):  
Santiago Milla-Navarro ◽  
Ariadna Diaz-Tahoces ◽  
Isabel Ortuño-Lizarán ◽  
Eduardo Fernández ◽  
Nicolás Cuenca ◽  
...  
Keyword(s):  
Harmful Effect ◽  
Receptor Activation ◽  
Structure And Function ◽  
Retinal Cell ◽  
Retinal Ganglion ◽  
Retinal Cells ◽  
Great Loss ◽  
Intraocular Injection ◽  
Glutamate Agonists ◽  
And Function

One of the causes of nervous system degeneration is an excess of glutamate released upon several diseases. Glutamate analogs, like N-methyl-DL-aspartate (NMDA) and kainic acid (KA), have been shown to induce experimental retinal neurotoxicity. Previous results have shown that NMDA/KA neurotoxicity induces significant changes in the full field electroretinogram response, a thinning on the inner retinal layers, and retinal ganglion cell death. However, not all types of retinal neurons experience the same degree of injury in response to the excitotoxic stimulus. The goal of the present work is to address the effect of intraocular injection of different doses of NMDA/KA on the structure and function of several types of retinal cells and their functionality. To globally analyze the effect of glutamate receptor activation in the retina after the intraocular injection of excitotoxic agents, a combination of histological, electrophysiological, and functional tools has been employed to assess the changes in the retinal structure and function. Retinal excitotoxicity caused by the intraocular injection of a mixture of NMDA/KA causes a harmful effect characterized by a great loss of bipolar, amacrine, and retinal ganglion cells, as well as the degeneration of the inner retina. This process leads to a loss of retinal cell functionality characterized by an impairment of light sensitivity and visual acuity, with a strong effect on the retinal OFF pathway. The structural and functional injury suffered by the retina suggests the importance of the glutamate receptors expressed by different types of retinal cells. The effect of glutamate agonists on the OFF pathway represents one of the main findings of the study, as the evaluation of the retinal lesions caused by excitotoxicity could be specifically explored using tests that evaluate the OFF pathway.

scholarly journals Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrain.

1994 ◽  
Vol 91 (23) ◽  
pp. 11271-11275 ◽  
Author(s):  
A. M. Murray ◽  
H. L. Ryoo ◽  
E. Gurevich ◽  
J. N. Joyce
Keyword(s):  
D2 Receptors ◽  
Dopamine D3 Receptors ◽  
D3 Receptors ◽  
Dopamine D3

Proteasome inhibitors enhance vitamin D3 signaling via inhibiting degradation of vitamin D3 receptors in human keratinocytes

1998 ◽  
Vol 16 ◽  
pp. S205
Author(s):  
XY Li ◽  
JH Xiao ◽  
GJ Fisher ◽  
JJ Voorhees
Keyword(s):  
Vitamin D3 ◽  
Proteasome Inhibitors ◽  
Human Keratinocytes ◽  
D3 Receptors
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