scholarly journals Promotion of skeletal muscle repair in a rat skeletal muscle injury model by local injection of human adipose tissue-derived regenerative cells

2012 ◽  
Vol 9 (10) ◽  
pp. 1150-1160 ◽  
Author(s):  
Ryo Mori ◽  
Naosuke Kamei ◽  
Shingo Okawa ◽  
Akihiro Nakabayashi ◽  
Kazunori Yokota ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Muscle Injury ◽  
Human Adipose Tissue ◽  
Local Injection ◽  
Muscle Repair ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Injury ◽  
Injury Model ◽  
Regenerative Cells

scholarly journals Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model

2009 ◽  
Vol 14 (10) ◽  
pp. 2495-2505 ◽  
Author(s):  
Tomoyuki Nakasa ◽  
Masakazu Ishikawa ◽  
Ming Shi ◽  
Hayatoshi Shibuya ◽  
Nobuo Adachi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Muscle Injury ◽  
Local Injection ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Injury ◽  
Injury Model

Losartan Improves Adipose Tissue-Derived Stem Cell Niche by Inhibiting Transforming Growth Factor-β and Fibrosis in Skeletal Muscle Injury

2012 ◽  
Vol 21 (11) ◽  
pp. 2407-2424 ◽  
Author(s):  
Jin-Kyu Park ◽  
Mi-Ran Ki ◽  
Eun-Mi Lee ◽  
Ah-Young Kim ◽  
Sang-Young You ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Muscle Injury ◽  
Transforming Growth Factor ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Type I ◽  
Skeletal Muscle Injury ◽  
Losartan Treatment

Recently, adipose tissue-derived stem cells (ASCs) were emerged as an alternative, abundant, and easily accessible source of stem cell therapy. Previous studies revealed losartan (an angiotensin II type I receptor blocker) treatment promoted the healing of skeletal muscle by attenuation of the TGF-β signaling pathway, which inhibits muscle differentiation. Therefore, we hypothesized that a combined therapy using ASCs and losartan might dramatically improve the muscle remodeling after muscle injury. To determine the combined effect of losartan with ASC transplantation, we created a muscle laceration mouse model. EGFP-labeled ASCs were locally transplanted to the injured gastrocnemius muscle after muscle laceration. The dramatic muscle regeneration and the remarkably inhibited muscular fibrosis were observed by combined treatment. Transplanted ASCs fused with the injured or differentiating myofibers. Myotube formation was also enhanced by ASC+ satellite coculture and losartan treatment. Thus, the present study indicated that ASC transplantation effect for skeletal muscle injury can be dramatically improved by losartan treatment inducing better niche.

Effect Of Avenathramide On Rat Skeletal Muscle Injury Induced By Lengthening Contraction

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S466 ◽  
Author(s):  
Kathleen M. O??Moore ◽  
C M. Vanlandschoot ◽  
J R. Dickman ◽  
A R. Figi ◽  
A M. Rothert ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Injury ◽  
Lengthening Contraction

Effect Of Avenathramide On Rat Skeletal Muscle Injury Induced By Lengthening Contraction

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S466 ◽  
Author(s):  
Kathleen M. OʼMoore ◽  
C M. Vanlandschoot ◽  
J R. Dickman ◽  
A R. Figi ◽  
A M. Rothert ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Injury ◽  
Lengthening Contraction
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