scholarly journals Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice

2010 ◽  
Vol 25 (6) ◽  
pp. 608-621 ◽  
Author(s):  
Anita K. Patlolla ◽  
Saber M. Hussain ◽  
John J. Schlager ◽  
Srikant Patlolla ◽  
Paul B. Tchounwou
2007 ◽  
Vol 62 (9-10) ◽  
pp. 679-683 ◽  
Author(s):  
Serap Çelikler ◽  
Nilüfer Aydemir ◽  
Rahmi Bilaloğlu

Pyrimethamine is an antimalarial agent widely used in clinical therapy. We aimed to compare its mutagenic potential in mammalian spermatogonial and bone marrow cells. For studying chromosomal aberrations mice were treated acutely (single treatment) with 4 dose levels of pyrimethamine (5, 10, 20 and 40 mg/kg). Pyrimethamine was found to produce a significant increase in structural chromosomal aberrations after acute treatment in bone marrow cells of mice (p < 0.001). It also induced chromosome abnormalities in spermatogonial cells (p < 0.05) at the highest dose.


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