Rheological Investigation of Lipid Polymer Hybrid Nanocarriers for Oral Delivery of Felodipine (Conference Paper )#

The rheological behavior among factors that are present in Stokes law can be used to control the stability of the colloidal dispersion system. The felodipine lipid polymer hybrid nanocarriers (LPHNs) is an interesting colloidal dispersion system that is used for rheological characteristic analysis. The LPHNs compose of polymeric components and lipids. This research aims to prepare oral felodipine LPHNs to investigate the effect of independent variables on the rheological behavior of the nanosystem. The microwave-based technique was used to prepare felodipine LPHNs (H1-H9) successfully. All the formulations enter the characterization process for particle size and PDI to ascertain the colloidal properties of the prepared nanosystem then use coaxial rotational digital rheometer for rheological evaluation. The outcomes show that all felodipine LPHNs formulations (H1-H9) had a nanosize and homogenous structure that ascertain colloidal features of the nanodispersion system. The rheogram chart indicates that all of the felodipine LPHNs formulations (H1-H9) show pseudoplastic flow (non-Newtonian flow) that have shear-thinning property. The microwave-based method prepares felodipine LPHNs formulations (H1-H9) that show excellent physical texture that ascertains its ability as a technique for the preparation of nanoparticles. All of the felodipine LPHNs formulations (H1-H9) show pseudoplastic flow that supports the physical stability of the nanosystem.

Extraction, Characterization and Rheological Behavior of Tamarind Gum Under High Salinity

The objective of this work was to obtain tamarind gum from Tamarindus indica L. seeds, which are waste from the food industry. Tamarind gum was extracted by two methods and the highest yield achieved was 32.6% w/w, containing 69.25% w/w of organic matter, which was composed mostly of the nonionic polysaccharide xyloglucan. The greatest molar mass of the tamarind gum was Mw=7.16 x 105 g/mol with polydispersity index (PI) of 1.7. Evaluation of the rheological behavior of tamarind gum samples were carried out in two brines (total dissolved solids values of 29,711 mg/L and 68,317 mg/L, containing divalent ions) that simulated petroleum reservoir salinity levels, with different temperatures (25, 60 and 80°C). The rheological curves indicated high salt resistance of the gum samples. Under a shear rate of 7.3 s-1 the highest viscosity values found were approximately 86, 41 and 50 cP with at concentration of 5,000 ppm and temperatures of 25, 60 and 80ºC, respectively.

Morphology and Rheology of a Cool-Gel (Protein) Blended with a Thermo-Gel (Hydroxypropyl Methylcellulose)

This study investigates the morphological and rheological properties of blended gelatin (GA; a cooling-induced gel (cool-gel)) and hydroxypropyl methylcellulose (HPMC; a heating-induced gel (thermo-gel)) systems using a fluorescence microscope, small angle X-ray scattering (SAXS), and a rheometer. The results clearly indicate that the two biopolymers are immiscible and have low compatibility. Moreover, the rheological behavior and morphology of the GA/HPMC blends significantly depend on the blending ratio and concentration. Higher polysaccharide contents decrease the gelling temperature and improve the gel viscoelasticity character of GA/HPMC blended gels. The SAXS results reveal that the correlation length (ξ) of the blended gels decreases from 5.16 to 1.89 nm as the HPMC concentration increases from 1 to 6%, which suggests that much denser networks are formed in blended gels with higher HPMC concentrations. Overall, the data reported herein indicate that the gel properties of gelatin can be enhanced by blending with a heating-induced gel.

Experimental Study of Rheological Behavior of MWCNT-Al2O3/SAE50 Hybrid Nanofluid to Provide the Best Nano-lubrication Conditions

In this study, MWCNT-Al2O3 hybrid nanoparticles with a composition ratio of 50:50 in SAE50 base oil are used. This paper aims to describe the rheological behavior of hybrid nanofluid based on temperature, shear rate ($$\dot{\gamma })$$ γ ˙ ) and volume fraction of nanoparticles ($$\varphi$$ φ ) to present an experimental correlation model. Flowmetric methods confirm the non-Newtonian behavior of the hybrid nanofluid. The highest increase and decrease in viscosity ($${\mu }_{\rm nf}$$ μ nf ) in the studied conditions are measured as 24% and − 17%, respectively. To predict the experimental data, the five-point-three-variable model is used in the response surface methodology with a coefficient of determination of 0.9979. Margin deviation (MOD) of the data is determined to be within the permissible limit of − 4.66% < MOD < 5.25%. Sensitivity analysis shows that with a 10% increase in $$\varphi$$ φ at $$\varphi =$$ φ = 1%, the highest increase in $${\mu }_{\rm nf}$$ μ nf of 34.92% is obtained.