P16.14: The association between ischemia-modified albumin levels in umbilical vein and intrauterine growth restriction

Abstract Background Intrauterine growth restriction (IUGR) is one of the causes of perinatal mortality and morbidity. It is the failure of the fetus to achieve intrinsic growth potential. Since IUGR neonates are more likely to suffer complications including perinatal asphyxia, cold stress, hypoglycemia, hypocalcaemia, hyperbilirubinemia, feed intolerance, NEC, sepsis and even mortality. So, it is important that these infants are identified and managed appropriately at birth. Purpose The present study aims to determine the possible association between cord blood ischemia-modified albumin (IMA) levels and intrauterine growth restriction (IUGR) in preterm infants with or without complicated gestations. Patients and Method Eighty mothers and their preterm neonates (<37 weeks’ gestation) identified in 2 groups according to antenatal ultrasound: a group with prospective antenatal diagnosis of IUGR and the other group with normal fetal development, after consideration of inclusion and exclusion criteria. Cord blood Albumin and Ischemia modified albumin were estimated by double-antibody sandwich Enzyme-Linked Immunosorbent Assay (ELISA). Results Cord blood IMA was significantly higher in IUGR group compared to control group. Consequently, albumin level was significantly lower in IUGR group compared to other group. IMA was inversely correlation with Hb level and albumin level was inversely correlated with liver function tests (ALT and AST). Conclusion There is a positive association between IMA level and IUGR. This sent a message that combined antenatal ultrasound and serum IMA is a better predictor of intrauterine growth restriction and subsequent better care of neonates with IUGR.

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Intrauterine growth restriction is associated with structural alterations in human umbilical cord and decreased nitric oxide-induced relaxation of umbilical vein

Placenta ◽

10.1016/j.placenta.2014.08.090 ◽

2014 ◽

Vol 35 (11) ◽

pp. 891-899 ◽

Cited By ~ 16

Author(s):

A.-C. Peyter ◽

F. Delhaes ◽

D. Baud ◽

Y. Vial ◽

G. Diaceri ◽

...

Keyword(s):

Nitric Oxide ◽

Umbilical Cord ◽

Intrauterine Growth Restriction ◽

Umbilical Vein ◽

Growth Restriction ◽

Human Umbilical Cord ◽

Structural Alterations ◽

Intrauterine Growth

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Prenatal visualization of paraumbilical veins in fetus with intra‐abdominal umbilical vein stricture and intrauterine growth restriction

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.20248 ◽

2019 ◽

Vol 54 (5) ◽

pp. 697-698

Author(s):

Y. M. Chan ◽

K. M. Law ◽

L. C. Y. Poon ◽

T. Y. Leung

Keyword(s):

Intrauterine Growth Restriction ◽

Umbilical Vein ◽

Growth Restriction ◽

Intrauterine Growth

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Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction

Clinical Science ◽

10.1042/cs20060161 ◽

2006 ◽

Vol 112 (1) ◽

pp. 51-57 ◽

Cited By ~ 125

Author(s):

Wenzel Wallner ◽

Ruth Sengenberger ◽

Reiner Strick ◽

Pamela L. Strissel ◽

Britta Meurer ◽

...

Keyword(s):

Growth Factors ◽

Growth Factor ◽

Intrauterine Growth Restriction ◽

Umbilical Artery ◽

Umbilical Vein ◽

Maternal Serum ◽

Growth Restriction ◽

Angiogenic Growth Factors ◽

Intrauterine Growth ◽

Umbilical Blood

The present study was performed to compare serum concentrations of maternal and fetal angiogenic growth factors in IUGR (intrauterine growth restriction) and normal pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth factor) were measured by ELISA in serum from a maternal peripheral vein, the umbilical vein and the umbilical arteries in 15 women with pregnancies complicated by IUGR and 16 controls (women with normal pregnancies). In IUGR, sFlt-1 was increased, and PlGF and sKDR were decreased, in both maternal serum and serum from the umbilical vein. Additionally, bFGF was increased in serum from the umbilical vein of women with pregnancies complicated by IUGR. No significant differences in growth factor concentrations between the groups were found in serum from the umbilical artery. In both groups, levels of VEGF were higher and levels of sFlt-1 were lower in serum from the umbilical vein and umbilical artery compared with maternal serum. PlGF levels were found to be lower in serum from the umbilical vein compared with maternal serum in both groups, whereas PlGF levels in serum from the umbilical artery were significantly lower only in the control group. These findings suggest an imbalance of angiogenic and anti-angiogenic factors in IUGR, with formation of an anti-angiogenic state in maternal and, to a lesser extent, umbilical vein blood. The placenta appears to play a central role in the release of sFlt-1 into maternal and umbilical blood. Umbilical artery blood was unaffected in IUGR, indicating that the fetus does not contribute to changes in angiogenic growth factor concentrations.

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