OC3.05: Prenatal diagnosis and outcome of congenital CMV infection in twin pregnancies

2005 ◽  
Vol 26 (4) ◽  
pp. 313-313
Author(s):  
S. Lipitz ◽  
Y. Yinon ◽  
S. Y. Yagel ◽  
M. Tepperberg ◽  
B. Feldman ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Twin Pregnancies ◽  
Congenital Cmv

scholarly journals Vertical Transmission and Discordance of Cytomegalovirus in Twin Pregnancies

2021 ◽  
Vol 11 ◽  
Author(s):  
Jill Hutton ◽  
Paul J. Rowan
Keyword(s):  
Vertical Transmission ◽  
Transmission Rate ◽  
Monozygotic Twin ◽  
Dizygotic Twin ◽  
Cmv Infection ◽  
Vertical Transmission Rate ◽  
Congenital Cmv Infection ◽  
Twin Pregnancies ◽  
Congenital Cmv ◽  
Singleton Pregnancies

ObjectiveThe objectives are to estimate the vertical transmission rate in twins relative to singleton pregnancies, to evaluate whether discordance within twin pairs is rare, and to characterize concordance within monozygotic and dizygotic twin pairs in relation to hereditability.MethodsWe first sought to estimate the vertical transmission rate of congenital CMV infection in twins by gathering cohort-based studies of congenital CMV in which vertical transmission in both singleton and twin pregnancies was reported. This also allowed us to compare singleton and twin infection rates. From the above studies and other large cohorts of congenitally infected infants, the percentage of discordantly infected twin pairs determined whether this is a rare phenomenon. Theorizing discordance is not rare, we then analyzed data from cases with twin outcomes for congenital CMV infection, according to whether the twins were monozygotic or dizygotic, and calculated their corresponding concordance rates to estimate the broad-sense heritability. Lastly, we described other factors that might affect vertical transmission.ResultsFrom five articles following at-risk pregnancies, the rate of vertical transmission in twin pregnancies is 58.7% (95% CI 43.3-72.3%) whereas in singleton pregnancies it is 31.4% (95% CI: 29.0-34.0%) p = 0.0002. Of ten studies of larger cohorts of infants with congenital CMV infection, 21 of 42 twin pairs with at least one twin infected were discordant for congenital CMV (50.0%, 95% CI: 34.4–65.6%) indicating discordance of congenital CMV infection in twin pairs is not rare. Of 28 studies covering 37 twin pairs where at least one twin had congenital CMV, and zygosity was known, eleven of thirteen monozygotic twin pairs (84.6%; 95% CI: 53.7-97.3%) were concordant for CMV infection, and nine of twenty-four dizygotic twin pairs (37.5%; 95% CI: 19.6-59.2%) were concordant for infection giving an estimated hereditability of 94.2%. Within these 37 twin pairs, factors such as primary or recurrent maternal infection, prematurity, growth discordance, and sex are described; however, in many of these cases these factors are unknown.ConclusionThe rate of vertical transmission of congenital CMV is higher for twins than singletons. Discordance of congenital CMV in twins is not rare and suggests a possible genetic susceptibility to congenital CMV.

scholarly journals OP22.13: Amniotic fluid RT-PCR for prenatal diagnosis of congenital CMV infection after suspicious ultrasound or maternal disease

2008 ◽  
Vol 32 (3) ◽  
pp. 388-389
Author(s):  
S. Yagel ◽  
O. Kaplan ◽  
N. Mador ◽  
L. Levitt ◽  
B. Shainberg ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Amniotic Fluid ◽  
Rt Pcr ◽  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Maternal Disease ◽  
Congenital Cmv

scholarly journals Testing for Cytomegalovirus in Pregnancy

2016 ◽  
Vol 55 (3) ◽  
pp. 693-702 ◽  
Author(s):  
Alda Saldan ◽  
Gabriella Forner ◽  
Carlo Mengoli ◽  
Nadia Gussetti ◽  
Giorgio Palù ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Fetal Blood ◽  
Resonance Imaging ◽  
Cmv Infection ◽  
Neurological Damage ◽  
Congenital Cytomegalovirus ◽  
Immune Mediated ◽  
Congenital Cmv Infection ◽  
Magnetic Resonance Imaging Mri ◽  
Congenital Cmv

ABSTRACT Congenital cytomegalovirus (CMV) infection represents a relevant cause of deafness and neurological damage in newborns. Intrauterine CMV transmission might result after primary or nonprimary infections, though at different rates (30% versus 0.2%, respectively). At present, a prenatal diagnosis of CMV infection is based mainly on maternal serology, the detection of CMV-DNA in amniotic fluid and fetal blood, and ultrasound (US) and magnetic resonance imaging (MRI). Recent evidences suggest that congenital CMV infection may be an immune-mediated disease and that evaluation of humoral and especially T-cell immunities may improve the overall prenatal diagnosis. This review summarizes the most recent advancements in the diagnosis of maternal and prenatal CMV infections.

scholarly journals Anticytomegalovirus (Anti-CMV) Immunoglobulin G Avidity in Identification of Pregnant Women at Risk of Transmitting Congenital CMV Infection

1999 ◽  
Vol 6 (1) ◽  
pp. 127-129 ◽  
Author(s):  
Tiziana Lazzarotto ◽  
Patrizia Spezzacatena ◽  
Stefania Varani ◽  
Liliana Gabrielli ◽  
Paola Pradelli ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Pregnant Women ◽  
Immunoglobulin G ◽  
Cmv Infection ◽  
Antibody Avidity ◽  
Helpful Tool ◽  
Congenital Cmv Infection ◽  
Infected Newborn ◽  
Congenital Cmv

ABSTRACT In this work, we show that the determination of the anticytomegalovirus antibody avidity carried out before week 18 of gestation is a helpful tool to identify women for enrollment in prenatal diagnosis. This procedure can identify all pregnant women who will give birth to an infected newborn.

A prospective study evaluating congenital CMV infection in Mayotte and La Reunion Islands (France)

2021 ◽  
Vol 138 ◽  
pp. 104793
Author(s):  
Justine Demortier ◽  
Jacques Fourgeaud ◽  
Soumeth Abasse ◽  
Laurent Lambrecht ◽  
Marie Gromand ◽  
...  
Keyword(s):  
Prospective Study ◽  
La Réunion ◽  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
A Prospective Study ◽  
Congenital Cmv

How to Save Money: Congenital CMV Infection and the Economy

2018 ◽  
pp. 121-144
Author(s):  
E. Walter ◽  
C. Brennig ◽  
V. Schöllbauer ◽  
Gabriele Halwachs-Baumann
Keyword(s):  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Congenital Cmv

scholarly journals OP02.08: Effectiveness of ultrasound in the antenatal prediction of symptomatic congenital CMV infection

2006 ◽  
Vol 28 (4) ◽  
pp. 423-423
Author(s):  
G. Simonazzi ◽  
B. Guerra ◽  
A. Banfi ◽  
G. Pilu ◽  
T. Lazzarotto ◽  
...  
Keyword(s):  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Congenital Cmv
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