P04.24: Lung volume assessment at midgestation with 3D ultrasound to predict pulmonary hypoplasia in fetuses with isolated congenital diaphragmatic hernia

2005 ◽  
Vol 26 (4) ◽  
pp. 402-402 ◽  
Author(s):  
J. Jani ◽  
T. Cos ◽  
A. Benachi ◽  
D. Van Schoubroeck ◽  
R. Ruano ◽  
...  
2006 ◽  
Vol 195 (6) ◽  
pp. S61
Author(s):  
Jacques Jani ◽  
Fabio Peralta ◽  
Alexandra Benachi ◽  
Rodrigo Ruano ◽  
Kypros Nicolaides ◽  
...  

PEDIATRICS ◽  
1995 ◽  
Vol 96 (6) ◽  
pp. 1117-1122
Author(s):  
Michael J. Antunes ◽  
Jay S. Greenspan ◽  
James A. Cullen ◽  
William J. Holt ◽  
Stephen Baumgart ◽  
...  

Objectives. To determine whether fatal pulmonary hypoplasia, as assessed by functional residual capacity (FRC), can be distinguished from other reversible causes of respiratory failure in infants with congenital diaphragmatic hernia (CDH). Methods. In the present study, 25 term neonates having CDH without other anomalies (mean birth weight ± SD, 3.25 ± 0.50 kg) were enrolled prospectively into a protocol evaluating pulmonary function. Lung compliance (CL) and FRC were measured before diaphragmatic repair and compared with the highest oxygenation index (OI) and lowest PaCO2, also obtained preoperatively. Pulmonary function assessment was repeated after diaphragm repair on postoperative days 3 and 7. CL was determined by esophageal manometry and pneumotachography, and FRC was determined by helium dilution. Results. Fifteen infants (60%) survived to hospital discharge. Eighteen (72%) required extracorporeal membrane oxygenation (ECMO) for support, and of these, 8 (44%) survived. PaCO2 was similar preoperatively in infants grouped as survivors without ECMO, survivors with ECMO, and nonsurvivors. In nonsurvivors (all of whom received ECMO), the preoperative OI was significantly higher (51 ± 21), CL was less (0.11 ± 0.04 mL/cm of water per kg), and FRC was smaller (4.5 ± 1.0 mL/kg) than in the survivors who required ECMO (26 ± 18, 0.18 ± 0.08 mL/cm of water per kg, and 12 ± 5 mL/kg, respectively), as well as in the survivors without ECMO, (6 ± 2, 0.32 ± 0.16 mL/cm of water per kg, and 15.8 ± 4 mL/kg, respectively). The group surviving with ECMO had a higher OI than the infants surviving without ECMO. All nonsurviving infants had FRCs of less than 9.0 mL/kg preoperatively. In contrast, only 2 of the 15 survivors had preoperative FRCs less than 9 mL/kg. Conclusions. The results of this study suggest that preoperative assessment of FRC may predict fatal pulmonary hypoplasia in most infants with CDH.


2003 ◽  
Vol 22 (S1) ◽  
pp. 139-139
Author(s):  
R. Ruano ◽  
A. Benachi ◽  
L. Joubin ◽  
M. C. Aubry ◽  
J. C. Thalabard ◽  
...  

Author(s):  
Ambereen A. Khan ◽  
Elizabeth A. Furey ◽  
April A. Bailey ◽  
Yin Xi ◽  
David T. Schindel ◽  
...  

1970 ◽  
Vol 7 (1) ◽  
pp. 28-30 ◽  
Author(s):  
SE Khan ◽  
AKMZ Siddiq ◽  
M Nessa

Introduction: Congenital diaphragmatic hernia (CDH) is one of the major surgical causes of respiratory distress in neonates. Reported survival averages 60% but may be significantly lower. Pulmonary hypertension and pulmonary hypoplasia are recognised as two corner stones of the pathophysiology of CDH. Objective: Objective of the study was to evaluate the outcome of this birth defect in Bangladesh situation. Method: This retrospective study was carried out at the Department of Paediatric Surgery of Combined Military Hospital, Dhaka over a period of five years. During this period a total of 8 neonates of CDH were admitted in this hospital. All the data were collected from record sheet and were compiled. Result: Age of patients ranged from 1 day to 20 days. Out of 8 neonates 5 (62.50%) were male and 3 (37.50%) were female. All patients were diagnosed postnatally. All the 8 neonates had Bochdalek type of CDH. Seven patients (87.50%) had left sided hernia. Two patients (25%) died before operation in the stabilization phase while on ventilator and 6 (75%) were operated. Out of these 6 patients, 5 (left sided) were operated through abdominal route and 1 (right sided) was approached through thorax. Overall outcome was satisfactory in 5 neonates and one died. Conclusion: Early intervention can result good prognosis in CDH. Key words: Congenital diaphragmatic hernia; neonate; Bochdalek type DOI: http://dx.doi.org/10.3329/jafmc.v7i1.8623 JAFMC Bangladesh. Vol 7, No 1 (June) 2011; 28-30  


Sign in / Sign up

Export Citation Format

Share Document