Early diagnosis of congenital cytomegalovirus infection after maternal primary infection in early pregnancy: a feasibility study of amplification of the viral genome by PCR on chorionic villi obtained by CVS

2021 ◽  
Author(s):  
V. Faure‐Bardon ◽  
J. Fourgeaud ◽  
T. Guilleminot ◽  
F. Magny ◽  
L. Salomon ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Feasibility Study ◽  
Early Pregnancy ◽  
Viral Genome ◽  
Primary Infection ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Chorionic Villi ◽  
Congenital Cytomegalovirus

scholarly journals Congenital Cytomegalovirus Infection Presenting with Hyperbilirubinemia and Splenomegaly in a Term Infant with Trisomy 21

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Kate Wilson ◽  
Lindsay Ellsworth ◽  
Megan H. Pesch
Keyword(s):  
Early Diagnosis ◽  
Critically Ill ◽  
Trisomy 21 ◽  
Cytomegalovirus Infection ◽  
Term Infant ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Cmv

Congenital cytomegalovirus infection (cCMV) is very common, yet the presentation can be varied, making the diagnosis challenging. However, early diagnosis for treatment with medication in symptomatic cases within the first month of life is critical. Hyperbilirubinemia and splenomegaly are less common manifestations at birth and may be overlooked in the setting of other symptoms, especially in a critically ill neonate. We present a case of a term infant with trisomy 21 who presented with isolated hyperbilirubinemia and splenomegaly and was later diagnosed with congenital CMV.

CONGENITAL CYTOMEGALOVIRUS INFECTION: CONSECUTIVE OCCURRENCE DUE TO VIRUSES WITH SIMILAR ANTIGENIC COMPOSITIONS

PEDIATRICS ◽  
1973 ◽  
Vol 52 (6) ◽  
pp. 788-794
Author(s):  
Sergio Stagno ◽  
David W. Reynolds ◽  
Alfred Lakeman ◽  
Leigh J. Charamella ◽  
Charles A. Alford
Keyword(s):  
Primary Infection ◽  
Cytomegalovirus Infection ◽  
Infected Child ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Antigenic Stimulus ◽  
Homologous Virus ◽  
Older Child

The occurrence of congenital cytomegalovirus infection in two siblings born three years apart is reported. Based on clinical and immunologic findings, the older child seems to have been exposed to a strong and prolonged antigenic stimulus, while the younger was probably affected by a reduced or modified load. Simultaneous complement-fixing (CF) and neutralizing (NT) antibody determinations done in infants and maternal sera suggest that the viruses isolated from both cases, if not identical, are antigenically quite similar and, furthermore, they are very close to AD-169 and Davis prototypes. Therefore, although the mother showed a significant antibody rise and became viuric during the second pregnancy, it is very unlikley that a new primary infection with an heterologous strain occurred, and we suggest endogenous reactivation or reinfection with the homologous virus. The implications of this finding with respect to counseling parents of a congenitally infected child about future pregnancies are discussed.

scholarly journals Clinical factor associated with congenital cytomegalovirus infection in pregnant women with non-primary infection

2018 ◽  
Vol 24 (9) ◽  
pp. 702-706 ◽  
Author(s):  
Hideto Yamada ◽  
Kenji Tanimura ◽  
Shinya Tairaku ◽  
Ichiro Morioka ◽  
Masashi Deguchi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Primary Infection ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Clinical Factor ◽  
Congenital Cytomegalovirus
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