OC08.03: Twin‐specific customised GROW versus uncustomised STORK fetal weight standards: stillbirth risk versus small for gestational age at birth in subgroups according to maternal size

Objective: To investigate the accuracy of fetal weight estimation made by the last prenatal ultrasound measurement in low birth weight newborns (<2500 g). Study Design: A total of 1082 women were evaluated in this retrospective cohort study. Demographic and clinical information of the mother and newborn and obstetric ultrasonography measurements and findings performed in the last week before birth were recorded. Accuracy of fetal weight estimation and parameters affecting it was investigated. Results: Accurate estimation rates were lower in the term compared to the preterm delivery group; and in the SGA group compared to the AGA group (respectively, p=0.016, p=0.032). Accurate estimation rates (p=0.182) were comparable between the 500-1500 g and 1501-2500 g subgroups. The multiple linear regression analysis showed that gestational age at birth, birth weight, examination during labor, and duration between examination to delivery were statistically significant for the accurate estimation(p=0.001) Conclusions: Accurate estimation rates were lower in the term compared to the preterm delivery group, and in the SGA group compared to the AGA group. The factors affecting accurate estimation were found to be gestational age at birth, birth weight, examination during labor, and duration between examination to delivery.Keywords: Accurate estimation rate, Duration between examination to delivery, Examination during

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Blood serum myokine irisin and adipocytokine levels in newborns small for gestational age at birth

Proceedings of the National Academy of Sciences of Belarus Medical series ◽

10.29235/1814-6023-2021-18-4-402-412 ◽

2021 ◽

Vol 18 (4) ◽

pp. 402-412

Author(s):

V. A. Prylutskaya ◽

A. V. Sukalo ◽

A. V. Goncharik

Keyword(s):

Blood Serum ◽

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Gestational Age ◽

Small For Gestational Age ◽

The Body ◽

Delivery Mode ◽

Gestational Age At Birth ◽

Age At Birth

In recent years, a number of the studies of myokine irisin in adults and isolated in newborns have been carried out. The role of adipocytokines in the growth and development of the fetus and children has been shown.The aim of the study was to assess the levels of myokine irisin and adipocytokines in newborns small for gestational age at birth and to analyze the relationship between the parameters of the hormonal status of children and their mothers.49 newborns and their mothers were examined. Two groups were identified: group 1 (Gr1) – newborns small for gestational age (n = 24), group 2 (Gr2) – newborns appropriate for gestational age (n = 25). The levels of irisin and adipocytokines in the blood serum were determined by the enzyme immunoassay.Newborns small for gestational age had significantly lower levels of leptin and IGF-1 in the umbilical cord blood compared to children with physical development corresponding to the gestational age. There were no significant differences in the irisin content of cord blood serum in newborn Gr1 compared with Gr2. The presence of significant positive correlations between the level of irisin in the umbilical cord blood of newborns small for gestational age and the body weight at birth was established. In Gr1, a positive relationship was found between the irisin levels of mothers and newborns (r = 0.518, p = 0.028). The differences in the irisin content between the groups were established, taking into account the delivery mode (p = 0.0104).The revealed statistically significant differences in the concentrations of the analyzed metabolic markers in mother–child pairs, their relationship with clinical and anthropometric parameters substantiate the possibility of using irisin and adipocytokines as predictors in predicting the formation of metabolic disorders of infants small for gestational age.

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