Transient non‐cyclical activity of external myometrium: consider this to avoid errors in diagnosis of adenomyosis and uterine anomalies

2022 ◽  
Author(s):  
J. M. Puente ◽  
L. Fernández ◽  
J. A. García‐Velasco
Keyword(s):  
Uterine Anomalies

Uterine anomalies and endometriosis

2020 ◽  
Vol 111 (1) ◽  
Author(s):  
Damaris Freytag ◽  
Liselotte Mettler ◽  
Nicolai Maass ◽  
Veronika Günther ◽  
Ibrahim Alkatout
Keyword(s):  
Uterine Anomalies

Correlation between CT virtual hysterosalpingography and magnetic resonance imaging in the evaluation of uterine anomalies

2010 ◽  
Vol 94 (4) ◽  
pp. S211
Author(s):  
P. Carrascosa ◽  
M. Baronio ◽  
C. Capuñay ◽  
J. Vallejos ◽  
M. Borghi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Uterine Anomalies ◽  
Virtual Hysterosalpingography

P11.08: Three-dimensional ultrasound in diagnosis of septate uterus in patients with suspected congenital uterine anomalies

2010 ◽  
Vol 36 (S1) ◽  
pp. 210-210
Author(s):  
B. Graupera ◽  
M. Pascual ◽  
B. Úbeda ◽  
L. Hereter ◽  
C. Pedrero ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Septate Uterus ◽  
Uterine Anomalies

Heritable aspects of uterine anomalies. I. Three familial aggregates with Müllerian fusion anomalies**Supported in part by NIH grants HD 11021 and HD 02841, and grants from the March of Dimes.

1983 ◽  
Vol 40 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Marion S. Verp ◽  
Joe Leigh Simpson ◽  
Sherman Elias ◽  
Sandra A. Carson ◽  
Gloria E. Sarto ◽  
...  
Keyword(s):  
Uterine Anomalies ◽  
March Of Dimes

727: Transvaginal ultrasonography to predict preterm birth in women with uterine anomalies

2008 ◽  
Vol 199 (6) ◽  
pp. S207
Author(s):  
Joan Crane ◽  
Heather Scott ◽  
Wendy Whittle ◽  
Sujata Chandra ◽  
Donna Hutchens
Keyword(s):  
Preterm Birth ◽  
Transvaginal Ultrasonography ◽  
Uterine Anomalies

scholarly journals OC13.05: Impact of uterine anomalies upon pregnancy in women conceiving following assisted reproduction treatment

2010 ◽  
Vol 36 (S1) ◽  
pp. 25-26
Author(s):  
Y. Chan ◽  
K. Jayaprakasan ◽  
S. Sur ◽  
S. R. Deb ◽  
J. S. Clewes ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Uterine Anomalies ◽  
Assisted Reproduction Treatment

Regulation of HOXA10 expression by phytoestrogens

2007 ◽  
Vol 292 (2) ◽  
pp. E435-E442 ◽  
Author(s):  
G. Eda Akbas ◽  
Xiaolan Fei ◽  
Hugh S. Taylor
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
In Utero ◽  
Estrogen Response Element ◽  
Mouse Uterus ◽  
Response Element ◽  
Estrogen Response ◽  
Uterine Anomalies ◽  
Mrna And Protein Expression ◽  
Adult Exposure

HOXA10 is necessary for normal development of the Müllerian duct, and continued adult expression in the uterus is necessary for female fertility. HOXA10 expression is altered by diethylstilbestrol, leading to uterine anomalies. Other endocrine disruptors may potentially lead to reproductive anomalies or dysfunction by altering HOXA10 expression. Here we investigated the effect of isoflavones on HOXA10 expression after in utero or adult exposure in the mouse. Genistein, but not diadzein, regulated HOXA10 mRNA and protein expression in the adult mouse uterus. In contrast, in utero genistein or diadzein exposure had no lasting effect on HOXA10 expression in the exposed offspring. Reporter gene expression driven by the HOXA10 estrogen response element was increased in a dose-responsive manner by genistein, but not daidzein. Neither estrogen receptor-α nor estrogen receptor-β binding to the HOXA10 estrogen response element was affected by genistein or daidzein. In utero exposure to isoflavones is unlikely to result in HOXA10-mediated developmental anomalies. Adult genistein exposure alters uterine HOXA10 expression, a potential mechanism by which this agent affects fertility.

scholarly journals Rates of Preterm Birth in Multiparous Women with Congenital Uterine Anomalies

2021 ◽  
pp. 100392
Author(s):  
Jenna S. HYNES ◽  
Amanda R. SCHWARTZ ◽  
Sarahn M. WHEELER ◽  
Tracy A. MANUCK ◽  
Sarah K. DOTTERS-KATZ
Keyword(s):  
Preterm Birth ◽  
Uterine Anomalies ◽  
Multiparous Women

P–540 A feasible diagnostic approach for the cryptic subtelomeric traslocations in early recurrent miscarriage patients by preimplantation genetic testing (PGT)

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Lledo ◽  
R Morales ◽  
J A Ortiz ◽  
A Cascales ◽  
A Fabregat ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Recurrent Miscarriage ◽  
Chromosome Translocation ◽  
Accurate Diagnosis ◽  
Molecular Techniques ◽  
Telomeric Region ◽  
Whole Genome ◽  
Preimplantation Genetic Testing ◽  
Uterine Anomalies ◽  
Cryptic Translocation

Abstract Study question Could cryptic subtelomeric traslocations in early recurrent miscarriage patients be diagnosed by preimplantation genetic testing? Summary answer PGT is a powerful tool to detect subtelomeric cryptic traslocations identifying the cause of early recurrent miscarriage and allowing subsequent genetic counselling. What is known already: Chromosome translocations are frequently associated with birth defects, spontaneous early pregnancy losses and infertility. However, submicroscopic traslocations (so-called cryptic traslocations) are too small to be detected by conventional karyotyping.. Due to balanced status, high resolution molecular techniques as arrayCGH are not able to detect it. Thus, cryptic traslocations detection is challenging. PGT is able to detect CNVs at higher resolution than routine karyotyping. Therefore, the recurrent diagnosis of CNV at embryo level could suggest a subchromosomal parental traslocation. The aim of this study is to investigate the feasibility of using PGT as an indicator of parental balanced cryptic traslocations. Study design, size, duration We included three couples who underwent PGT for unexplained repeated pregnancy loss (RPL) in our clinic from February 2020 to November 2020. Common established causes of RPL (uterine anomalies, antiphospholipid syndrome, immunological, hormonal and metabolic disorders) were previously rouled-out. Even couple karyotypes were normal. Twenty-three embryos from those couples were biopsied at blastocyst and analysed for CNVs detection using low coverage whole genome NGS. Participants/materials, setting, methods PGT by NGS was performed by Veriseq-NGS (Illumina), with previous whole genome amplification. Fluorescence in situ hybridization (FISH) using parental blood samples were performed to validate the origin of subchromosomal number variation. Commercially available subtelomeric specific probes were selected according to the CNV identified and the procedures were performed according to the manufacturer’s protocols. Main results and the role of chance Overall, CNVs of terminal duplication and deletion that imply unbalanced traslocation derivatives were detected in the 43.5% of biopsied embryos. For couple 1, 4 out of 5 embryos (80%) carried deletion of telomeric region on chromosomes 5 and 21. Three out of 6 biopsed embyos (50%) were diagnosed with subchromosomal copy variants at telomeric region on chromosomes 6 and 16 for couple 2. In the case of couple 3, three out of 12 embryos (25%) were carriers of CNV at subtelomeric region on chromosomes 2 and 6. The size of CNVs detected ranges from 8Mb to 20Mb. Accurate diagnosis with the parental study was made by FISH. The combination of probes to detect the structural chromosome alteration were: Tel5qter-LSI21q, Tel6pter-CEP16 and Tel6pter-CEP6 for each couple respectively. The FISH studies reveal that CNVs were inherited from one parent carrying the balanced cryptic traslocation. Ultimately, the abnormal karyotype from the carrier parent were 46,XY,t(5;21)(q33.2;q21.2) for couple 1, 46,XY,t(6;16)(p22.3;q22.1) for couple 2 and 46,XY,t(2;6)(p25.1;p24.2) for couple 3. Finally, each couple performed a cryotransfer of a single normal balanced embryo. Two pregnancies are ongoing. Limitations, reasons for caution The main limitation of this approach is the NGS- PGT resolution. CNVs smaller than 5Mb could not be detected. Wider implications of the findings: This study shows the value of PGT for unexplained RPL, followed by parental FISH to better characterize CNVs and identify couples in whom one partner carries a cryptic translocation. Accurate diagnosis of parental chromosome translocation can achieve with FISH only, but FISH would not be performed unless PGT showed CNVs. Trial registration number Not applicable

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