scholarly journals OC125: New “suspension” endoscopic technique to correct fetal myelomeningocele: a pilot study in the ovine model

2006 ◽  
Vol 28 (4) ◽  
pp. 395-395
Author(s):  
D. A. L. Pedreira ◽  
R. C. S. Oliveira ◽  
P. R. Valente ◽  
R. C. Abou-Jamra ◽  
A. Araújo ◽  
...  
Keyword(s):  
Pilot Study ◽  
Endoscopic Technique ◽  
Ovine Model

Experimental Ovine Model of Primary Venous Valve Incompetence: A Pilot Study

2007 ◽  
Vol 18 (9) ◽  
pp. 1169-1175 ◽  
Author(s):  
Won Kyu Park ◽  
Dusan Pavcnik ◽  
Brad Shirley ◽  
Wei Lu ◽  
Barry T. Uchida ◽  
...  
Keyword(s):  
Pilot Study ◽  
Ovine Model ◽  
Venous Valve

Endoscopic Carpal Tunnel Decompression

1994 ◽  
Vol 19 (1) ◽  
pp. 5-13 ◽  
Author(s):  
M. W. H. ERDMANN
Keyword(s):  
Pilot Study ◽  
Carpal Tunnel ◽  
Endoscopic Surgery ◽  
Carpal Tunnel Release ◽  
Endoscopic Technique ◽  
Pinch Strength ◽  
Main Trial ◽  
Open Release ◽  
Prospective Pilot Study ◽  
Average Return

A study of endoscopic carpal tunnel release was carried out in three parts, consisting of initial cadaveric dissections, a prospective pilot study of 20 patients and a prospective, randomized trial of 71 patients comparing endoscopic with open decompression. In the main trial, 25 patients with bilateral symptoms underwent simultaneous endoscopic and open release, with the remainder randomized to one or other technique. Both techniques effectively decompressed the median nerve. A significant improvement in grip and pinch strength over 3 months was achieved in those undergoing endoscopic surgery. Average return to work was 14 days in the endoscopic series and 39 days in the open series. A complication rate of 35% was achieved with the transbursal endoscopic technique, 3.7% with the extrabursal endoscopic technique and 13.5% in the open series.

scholarly journals Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study

2015 ◽  
Vol 104 (8) ◽  
pp. 1713-1720 ◽  
Author(s):  
Brandi B. Scully ◽  
Christopher Fan ◽  
Bagrat Grigoryan ◽  
Jeffrey G. Jacot ◽  
G. W. Vick ◽  
...  
Keyword(s):  
Pilot Study ◽  
Ovine Model

scholarly journals Surviving Lambs with Myelomeningocele Repaired in utero with Placental Mesenchymal Stromal Cells for 6 Months: A Pilot Study

2020 ◽  
Vol 47 (12) ◽  
pp. 912-917
Author(s):  
Kaeli Yamashiro ◽  
Laura A. Galganski ◽  
Jamie Peyton ◽  
Kalie Haynes ◽  
Victoria Vicuna ◽  
...  
Keyword(s):  
Pilot Study ◽  
Physical Therapy ◽  
Motor Function ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Additional Treatment ◽  
Paraspinal Muscles ◽  
Ovine Model ◽  
Postnatal Treatment ◽  
Fetal Repair

<b><i>Background:</i></b> Fetal repair of myelomeningocele (MMC) with placental mesenchymal stromal cells (PMSCs) rescues ambulation in the ovine model up to 48 h postnatally. Outcomes past 48 h are unknown as MMC lambs have not been survived past this timepoint. <b><i>Objective:</i></b> We aimed to survive lambs for 6 months following the fetal repair of MMC with PMSCs. <b><i>Methods:</i></b> Fetal MMC lambs were repaired with PMSCs. Lambs received either no additional treatment or postnatal bracing and physical therapy (B/PT). Motor function was assessed with the sheep locomotor rating (SLR). Lambs with an SLR of 15 at birth were survived for 6 months or until a decline in SLR less than 15, whichever came first. All lambs underwent a perimortem MRI. <b><i>Results:</i></b> The lambs with no postnatal treatment (<i>n</i> = 2) had SLR declines to 7 and 13 at 29 and 65 days, respectively, and were euthanized. These lambs had a spinal angulation of 57° and 47°, respectively. The B/PT lamb (<i>n</i> = 1) survived for 6 months with a sustained SLR of 15 and a lumbar angulation of 42°. <b><i>Conclusion:</i></b> Postnatal physical therapy and bracing counteracted the inherent morbidity of the absent paraspinal muscles in the ovine MMC model allowing for survival and maintenance of rescued motor function of the prenatally treated lamb up to 6 months.

scholarly journals Use of Acellular Fish Skin for Dura Repair in an Ovine Model: A Pilot Study

2015 ◽  
Vol 05 (04) ◽  
pp. 124-136
Author(s):  
Hilmar Kjartansson ◽  
Ingvar Hakon Olafsson ◽  
Sigurbergur Karason ◽  
Hjalti Thorisson ◽  
Baldur Tumi Baldursson ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fish Skin ◽  
Ovine Model

scholarly journals Successful Development of a Fetal Ovine Model for Esophagus Tissue Engineering

2018 ◽  
Vol 7 (3) ◽  
pp. 33
Author(s):  
Amulya K Saxena ◽  
Herwig Ainoedhofer ◽  
Piotr Soltysiak
Keyword(s):  
Tissue Engineering ◽  
Pilot Study ◽  
Clinical Applications ◽  
Large Animal ◽  
Ovine Model ◽  
Collagen Scaffolds ◽  
Successful Development ◽  
Large Animal Models ◽  
Ovine Fetal

In esophagus tissue engineering, large animal models need to be developed to generate tissues of substantive size that can be applied in the future for clinical applications. The ovine fetal model has been successfully developed in this pilot study for esophagus tissue generation. Fetus (n = 5) was operated between the 120 and 125 days of gestation (term 140 days) with a longitudinal neck incision through which the esophagus was exposed. Full-thickness esophagus biopsies were obtained after which an end-to-end anastomosis was performed. Organoid units isolated from biopsies were seeded on collagen scaffolds to create tubular constructs which were implanted into the fetal omentum. The fetuses were returned and the pregnancy continued. There was no mortality and all five lambs were delivered at term. “Rudimentary” tissue engineered esophagus was generated using the omentum as an in situ bioreactor. The ovine fetal model for esophagus tissue engineering could successfully be established in this pilot study.

Pilot study on criteria in cavity preparation-facts or artifacts?

1973 ◽  
Vol 37 (11) ◽  
pp. 27-31 ◽  
Author(s):  
G Salvendy ◽  
WM Hinton ◽  
GW Ferguson ◽  
PR Cunningham
Keyword(s):  
Pilot Study ◽  
Cavity Preparation
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