scholarly journals Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study

2015 ◽  
Vol 104 (8) ◽  
pp. 1713-1720 ◽  
Author(s):  
Brandi B. Scully ◽  
Christopher Fan ◽  
Bagrat Grigoryan ◽  
Jeffrey G. Jacot ◽  
G. W. Vick ◽  
...  
Keyword(s):  
2007 ◽  
Vol 18 (9) ◽  
pp. 1169-1175 ◽  
Author(s):  
Won Kyu Park ◽  
Dusan Pavcnik ◽  
Brad Shirley ◽  
Wei Lu ◽  
Barry T. Uchida ◽  
...  
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2006 ◽  
Vol 28 (4) ◽  
pp. 395-395
Author(s):  
D. A. L. Pedreira ◽  
R. C. S. Oliveira ◽  
P. R. Valente ◽  
R. C. Abou-Jamra ◽  
A. Araújo ◽  
...  

2020 ◽  
Vol 47 (12) ◽  
pp. 912-917
Author(s):  
Kaeli Yamashiro ◽  
Laura A. Galganski ◽  
Jamie Peyton ◽  
Kalie Haynes ◽  
Victoria Vicuna ◽  
...  

<b><i>Background:</i></b> Fetal repair of myelomeningocele (MMC) with placental mesenchymal stromal cells (PMSCs) rescues ambulation in the ovine model up to 48 h postnatally. Outcomes past 48 h are unknown as MMC lambs have not been survived past this timepoint. <b><i>Objective:</i></b> We aimed to survive lambs for 6 months following the fetal repair of MMC with PMSCs. <b><i>Methods:</i></b> Fetal MMC lambs were repaired with PMSCs. Lambs received either no additional treatment or postnatal bracing and physical therapy (B/PT). Motor function was assessed with the sheep locomotor rating (SLR). Lambs with an SLR of 15 at birth were survived for 6 months or until a decline in SLR less than 15, whichever came first. All lambs underwent a perimortem MRI. <b><i>Results:</i></b> The lambs with no postnatal treatment (<i>n</i> = 2) had SLR declines to 7 and 13 at 29 and 65 days, respectively, and were euthanized. These lambs had a spinal angulation of 57° and 47°, respectively. The B/PT lamb (<i>n</i> = 1) survived for 6 months with a sustained SLR of 15 and a lumbar angulation of 42°. <b><i>Conclusion:</i></b> Postnatal physical therapy and bracing counteracted the inherent morbidity of the absent paraspinal muscles in the ovine MMC model allowing for survival and maintenance of rescued motor function of the prenatally treated lamb up to 6 months.


2015 ◽  
Vol 05 (04) ◽  
pp. 124-136
Author(s):  
Hilmar Kjartansson ◽  
Ingvar Hakon Olafsson ◽  
Sigurbergur Karason ◽  
Hjalti Thorisson ◽  
Baldur Tumi Baldursson ◽  
...  
Keyword(s):  

2018 ◽  
Vol 7 (3) ◽  
pp. 33
Author(s):  
Amulya K Saxena ◽  
Herwig Ainoedhofer ◽  
Piotr Soltysiak

In esophagus tissue engineering, large animal models need to be developed to generate tissues of substantive size that can be applied in the future for clinical applications. The ovine fetal model has been successfully developed in this pilot study for esophagus tissue generation. Fetus (n = 5) was operated between the 120 and 125 days of gestation (term 140 days) with a longitudinal neck incision through which the esophagus was exposed. Full-thickness esophagus biopsies were obtained after which an end-to-end anastomosis was performed. Organoid units isolated from biopsies were seeded on collagen scaffolds to create tubular constructs which were implanted into the fetal omentum. The fetuses were returned and the pregnancy continued. There was no mortality and all five lambs were delivered at term. “Rudimentary” tissue engineered esophagus was generated using the omentum as an in situ bioreactor. The ovine fetal model for esophagus tissue engineering could successfully be established in this pilot study.


1973 ◽  
Vol 37 (11) ◽  
pp. 27-31 ◽  
Author(s):  
G Salvendy ◽  
WM Hinton ◽  
GW Ferguson ◽  
PR Cunningham

2019 ◽  
Vol 62 (9) ◽  
pp. 3397-3412
Author(s):  
Michelle I. Brown ◽  
David Trembath ◽  
Marleen F. Westerveld ◽  
Gail T. Gillon

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent–child eye contact, and (c) parent–child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR intervention reported for babies without HL were also observed in babies with HL. Method Four mother–baby dyads participated in a multiple baseline single-case experimental design across behaviors. Treatment effects for parents' book selection skills, parent–child eye contact, and parent–child turn-taking were examined using visual analysis and Tau-U analysis. Results Statistically significant increases, with large to very large effect sizes, were observed for all 4 participants for parent–child eye contact and parent–child turn-taking. Limited improvements with ceiling effects were observed for parents' book selection skills. Conclusion The findings provide preliminary evidence for the effectiveness of an ESR intervention for babies with HL for promoting parent–child interactions through eye contact and turn-taking.


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