scholarly journals Inside Front Cover: Hybrid nano‐ and microgels doped with photoacoustic contrast agents for cancer theranostics (View 6/2021)

View ◽  
2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Yu Xiao ◽  
Jérôme Gateau ◽  
Amanda K A Silva ◽  
Xiangyang Shi ◽  
Florence Gazeau ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Front Cover ◽  
Cancer Theranostics

scholarly journals Hybrid nano‐ and microgels doped with photoacoustic contrast agents for cancer theranostics

View ◽  
2021 ◽  
pp. 20200176
Author(s):  
Yu Xiao ◽  
Jérôme Gateau ◽  
Amanda K A Silva ◽  
Xiangyang Shi ◽  
Florence Gazeau ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Cancer Theranostics

scholarly journals Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingxue Wang ◽  
Ju Huang ◽  
Weichen Zhou ◽  
Jiawen Zhao ◽  
Qi Peng ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Contrast Agents ◽  
Therapeutic Effects ◽  
Non Invasive ◽  
Drug Nanoparticles ◽  
Theranostic Nanoparticles ◽  
Anti Cancer ◽  
Therapy Strategies ◽  
Cancer Theranostics ◽  
Dual Drug

Abstract Background Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs). Results On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment. Conclusion Multifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics. Graphical Abstract

scholarly journals Front Cover: Tunable Performance of Manganese Oxide Nanostructures as MRI Contrast Agents (Chem. Eur. J. 6/2018)

2017 ◽  
Vol 24 (6) ◽  
pp. 1217-1217
Author(s):  
Manuel Bañobre-López ◽  
Lorena García-Hevia ◽  
M. Fatima Cerqueira ◽  
Francisco Rivadulla ◽  
Juan Gallo
Keyword(s):  
Contrast Agents ◽  
Manganese Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Front Cover ◽  
Oxide Nanostructures

scholarly journals Front Cover: Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T 1 MRI Contrast Agents (ChemMedChem 12/2020)

ChemMedChem ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. 1002-1002
Author(s):  
Akanksha Patel ◽  
Didar Asik ◽  
Eric M. Snyder ◽  
Alexandra E. Dilillo ◽  
Paul J. Cullen ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Front Cover

scholarly journals Nanomaterials incorporated ultrasound contrast agents for cancer theranostics

2016 ◽  
Vol 13 (3) ◽  
pp. 313-324 ◽  
Author(s):  
Lei Fu ◽  
Lei Fu ◽  
Heng-Te Ke ◽  
Heng-Te Ke
Keyword(s):  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast ◽  
Cancer Theranostics

scholarly journals Recent Development of Gold Nanoparticles as Contrast Agents for Cancer Diagnosis

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1825
Author(s):  
Dong Luo ◽  
Xinning Wang ◽  
Clemens Burda ◽  
James P. Basilion
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Fluorescence Imaging ◽  
Cancer Diagnosis ◽  
Biomedical Applications ◽  
Photoacoustic Imaging ◽  
Nuclear Imaging ◽  
Cancer Therapies ◽  
Optical And Electronic Properties ◽  
Cancer Theranostics

The last decade has witnessed the booming of preclinical studies of gold nanoparticles (AuNPs) in biomedical applications, from therapeutics delivery, imaging diagnostics, to cancer therapies. The synthetic versatility, unique optical and electronic properties, and ease of functionalization make AuNPs an excellent platform for cancer theranostics. This review summarizes the development of AuNPs as contrast agents to image cancers. First, we briefly describe the AuNP synthesis, their physical characteristics, surface functionalization and related biomedical uses. Then we focus on the performances of AuNPs as contrast agents to diagnose cancers, from magnetic resonance imaging, CT and nuclear imaging, fluorescence imaging, photoacoustic imaging to X-ray fluorescence imaging. We compare these imaging modalities and highlight the roles of AuNPs as contrast agents in cancer diagnosis accordingly, and address the challenges for their clinical translation.

scholarly journals Hypoxia Modulation by Dual-drug Nanoparticles for Enhanced Synergistic Sonodynamic and Starvation Therapy

2020 ◽  
Author(s):  
Jingxue Wang ◽  
Ju Huang ◽  
Weichen Zhou ◽  
Jiawen Zhao ◽  
Peng Qi ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Contrast Agents ◽  
Therapeutic Effects ◽  
Non Invasive ◽  
Drug Nanoparticles ◽  
Theranostic Nanoparticles ◽  
Anti Cancer ◽  
Therapy Strategies ◽  
Cancer Theranostics ◽  
Dual Drug

Abstract Background: Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs). Results: On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment. Conclusion: Multifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics.

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