scholarly journals Effects of GonaCon immunocontraceptive vaccine in free-ranging female Rocky Mountain elk (Cervus elaphus nelsoni)

2014 ◽  
Vol 38 (3) ◽  
pp. 650-656 ◽  
Author(s):  
Jenny G. Powers ◽  
Ryan J. Monello ◽  
Margaret A. Wild ◽  
Terry R. Spraker ◽  
James P. Gionfriddo ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Rocky Mountain ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk ◽  
Free Ranging ◽  
Immunocontraceptive Vaccine

scholarly journals PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease

1999 ◽  
Vol 80 (10) ◽  
pp. 2765-2679 ◽  
Author(s):  
K. I. O’Rourke ◽  
T. E. Besser ◽  
M. W. Miller ◽  
T. F. Cline ◽  
T. R. Spraker ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Transmissible Spongiform Encephalopathies ◽  
Spongiform Encephalopathy ◽  
Wasting Disease ◽  
Jakob Disease ◽  
Rocky Mountain Elk ◽  
Free Ranging ◽  
Prp Gene

The PrP gene encodes the putative causative agent of the transmissible spongiform encephalopathies (TSEs), a heterogeneous group of fatal, neurodegenerative disorders including human Creutzfeldt–Jakob disease, bovine spongiform encephalopathy, ovine scrapie and chronic wasting disease (CWD) of North American deer and elk. Polymorphisms in the PrP gene are associated with variations in relative susceptibility, pathological lesion patterns, incubation times and clinical course of TSEs of humans, mice and sheep. Sequence analysis of the PrP gene from Rocky Mountain elk showed only one amino acid change (Met to Leu at cervid codon 132). Homozygosity for Met at the corresponding polymorphic site (Met to Val) in humans (human codon 129) predisposes exposed individuals to some forms of Creutzfeldt–Jakob disease. In this study, Rocky Mountain elk homozygous for PrP codon 132 Met were over-represented in both free- ranging and farm-raised CWD-affected elk when compared to unaffected control groups.

Body Mass and Antler Development Patterns of Rocky Mountain Elk (Cervus elaphus nelsoni) in Michigan

2003 ◽  
Vol 150 (1) ◽  
pp. 169-180 ◽  
Author(s):  
LOUIS C. BENDER ◽  
ELAINE CARLSON ◽  
STEPHEN M. SCHMITT ◽  
JONATHAN B. HAUFLER
Keyword(s):  
Body Mass ◽  
Cervus Elaphus ◽  
Rocky Mountain ◽  
Development Patterns ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk ◽  
Antler Development

scholarly journals Detection of PrPCWDin Postmortem Rectal Lymphoid Tissues in Rocky Mountain Elk (Cervus Elaphus Nelsoni) Infected with Chronic Wasting Disease

2006 ◽  
Vol 18 (6) ◽  
pp. 553-557 ◽  
Author(s):  
Terry R. Spraker ◽  
Thomas L. Gidlewski ◽  
Aru Balachandran ◽  
Kurt C. VerCauteren ◽  
Lynn Creekmore ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Lymphoid Tissues ◽  
Wasting Disease ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk

Use of Acepromazine and Medetomidine in Combination for Sedation and Handling of Rocky Mountain Elk (Cervus elaphus nelsoni) and Black Bears (Ursus americanus)

2014 ◽  
Vol 50 (4) ◽  
pp. 979-981 ◽  
Author(s):  
Lisa L. Wolfe ◽  
Heather E. Johnson ◽  
Mark C. Fisher ◽  
Michael A. Sirochman ◽  
Benjamin Kraft ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Ursus Americanus ◽  
Rocky Mountain ◽  
Black Bears ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk

DETECTION OF PrPCWD IN FECES FROM NATURALLY EXPOSED ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI) USING PROTEIN MISFOLDING CYCLIC AMPLIFICATION

2012 ◽  
Vol 48 (2) ◽  
pp. 425-434 ◽  
Author(s):  
Bruce Pulford ◽  
Terry R. Spraker ◽  
A. Christy Wyckoff ◽  
Crystal Meyerett ◽  
Heather Bender ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Protein Misfolding ◽  
Rocky Mountain ◽  
Protein Misfolding Cyclic Amplification ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk

scholarly journals Transmission of Elk and Deer Prions to Transgenic Mice

2006 ◽  
Vol 80 (18) ◽  
pp. 9104-9114 ◽  
Author(s):  
Gültekin Tamgüney ◽  
Kurt Giles ◽  
Essia Bouzamondo-Bernstein ◽  
Patrick J. Bosque ◽  
Michael W. Miller ◽  
...  
Keyword(s):  
Prion Disease ◽  
Cervus Elaphus ◽  
Prion Diseases ◽  
Mule Deer ◽  
Transmitted Disease ◽  
Wild Type Mouse ◽  
Rocky Mountain ◽  
Odocoileus Hemionus ◽  
Cervus Elaphus Nelsoni ◽  
Free Ranging

ABSTRACT Chronic wasting disease (CWD) is a fatal prion disease in deer and elk. Unique among the prion diseases, it is transmitted among captive and free-ranging animals. To facilitate studies of the biology of CWD prions, we generated five lines of transgenic (Tg) mice expressing prion protein (PrP) from Rocky Mountain elk (Cervus elaphus nelsoni), denoted Tg(ElkPrP), and two lines of Tg mice expressing PrP common to white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus), denoted Tg(DePrP). None of the Tg(ElkPrP) or Tg(DePrP) mice exhibited spontaneous neurologic dysfunction at more than 600 days of age. Brain samples from CWD-positive elk, white-tailed deer, and mule deer produced disease in Tg(ElkPrP) mice between 180 and 200 days after inoculation and in Tg(DePrP) mice between 300 and 400 days. One of eight cervid brain inocula transmitted disease to Tg(MoPrP)4053 mice overexpressing wild-type mouse PrP-A in ∼540 days. Neuropathologic analysis revealed abundant PrP amyloid plaques in the brains of ill mice. Brain homogenates from symptomatic Tg(ElkPrP) mice produced disease in 120 to 190 days in Tg(ElkPrP) mice. In contrast to the Tg(ElkPrP) and Tg(DePrP) mice, Tg mice overexpressing human, bovine, or ovine PrP did not develop prion disease after inoculation with CWD prions from among nine different isolates after >500 days. These findings suggest that CWD prions from elk, mule deer, and white-tailed deer can be readily transmitted among these three cervid species.

scholarly journals VALIDATION OF A BRUCELLA ABORTUS COMPETITIVE ENZYME-LINKED IMMUNOSORBENT ASSAY FOR USE IN ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI)

2003 ◽  
Vol 39 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Clayton K. Van Houten ◽  
E. Lee Belden ◽  
Terry J. Kreeger ◽  
Elizabeth S. Williams ◽  
William H. Edwards ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Cervus Elaphus ◽  
Brucella Abortus ◽  
Rocky Mountain ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk
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