An integrative multiscale view of early cardiac looping

2021 ◽  
Author(s):  
Nazanin Ebrahimi ◽  
Christopher Bradley ◽  
Peter Hunter
Keyword(s):  
Cardiac Looping

Inhibition of proteoglycan synthesis eliminates left-right asymmetry in Xenopus laevis cardiac looping

Development ◽  
1990 ◽  
Vol 110 (3) ◽  
pp. 865-874 ◽  
Author(s):  
H.J. Yost
Keyword(s):  
Xenopus Laevis ◽  
Heparan Sulfate ◽  
Critical Period ◽  
Heparan Sulfate Proteoglycans ◽  
The Other ◽  
Proteoglycan Synthesis ◽  
Ventral Midline ◽  
Cardiac Looping ◽  
Left Right Asymmetry

The heart of any vertebrate is formed from an apparently symmetric cardiac tube that loops consistently in the same direction along the left-right axis of the embryo. In the amphibian Xenopus laevis, inhibition of proteoglycan synthesis by p-nitrophenyl-beta-D-xylopyranoside during a narrow period of development from late gastrula to early neurula specifically eliminated the looping of the cardiac tube. Most of the proteoglycans synthesized during this period were heparan sulfate proteoglycans. Treatment with p-nitrophenyl-alpha-D-xylopyranoside, an analogue that does not inhibit proteoglycan synthesis, did not interfere with cardiac looping. The critical period for proteoglycan synthesis was coincident with the migration of cardiac primordia to the ventral midline. The inhibition of cardiac looping was further explored in explants of cardiac primordia and anterioventral ectoderm. In recombinate embryos in which half the embryo, and thus one of the two heart primordia, was treated with p-nitrophenyl-beta-D-xylopyranoside, and the other half was untreated, cardiac looping occurred normally. It is proposed that the left-right axis in Xenopus, as reflected in cardiac looping, is established early in development, and that proteoglycan synthesis is involved in the transduction of left-right axial information to the cardiac primordia during migration.

scholarly journals Chimeric Analysis of Retinoic Acid Receptor Function during Cardiac Looping

2002 ◽  
Vol 247 (1) ◽  
pp. 62-75 ◽  
Author(s):  
Angelo Iulianella ◽  
David Lohnes
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Receptor Function ◽  
Cardiac Looping ◽  
Acid Receptor

scholarly journals Morphogenetic control of zebrafish cardiac looping by Bmp signaling

Development ◽  
2019 ◽  
Vol 146 (22) ◽  
pp. dev180091 ◽  
Author(s):  
Verónica A. Lombardo ◽  
Melina Heise ◽  
Motahareh Moghtadaei ◽  
Dorothee Bornhorst ◽  
Jörg Männer ◽  
...  
Keyword(s):  
Bmp Signaling ◽  
Cardiac Looping

Establishing Left-Right Patterning and Cardiac Looping

2007 ◽  
pp. 1-1
Author(s):  
Deepak Srivastava
Keyword(s):  
Cardiac Looping

scholarly journals Shortened outflow tract leads to altered cardiac looping after neural crest ablation

2002 ◽  
Vol 39 ◽  
pp. 408
Author(s):  
Talat Mesud Yelbuz ◽  
Karen L. Waldo ◽  
Donna H. Kumiski ◽  
Harriett A. Stadt ◽  
Raymond R. Wolfe ◽  
...  
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Looping

scholarly journals Proprotein Convertase Furina Is Required for Heart Development in Zebrafish

2021 ◽  
Author(s):  
Qinchao Zhou ◽  
Lei Lei ◽  
Hefei Zhang ◽  
Shih-Ching Chiu ◽  
Lu Gao ◽  
...  
Keyword(s):  
Heart Development ◽  
Positional Cloning ◽  
Notch Receptor ◽  
Post Translational Modification ◽  
Proprotein Convertase ◽  
Cardiac Looping ◽  
Heart Looping ◽  
Pharyngeal Arch Arteries ◽  
Underlying Mechanisms ◽  
Mutant Phenotypes

Cardiac looping and trabeculation are key processes during cardiac chamber maturation. However, the underlying mechanisms remain incompletely understood. Here, we report the isolation, cloning, and characterization of the proprotein convertase furina from the cardiovascular mutant loft in zebrafish. loft is an ethylnitrosourea-induced mutant and has evident defects in the cardiac outflow tract, heart looping and trabeculation, the craniofacial region, and pharyngeal arch arteries. Positional cloning revealed that furina mRNA was barely detectable in loft mutants, and loft failed to complement the TALEN-induced furina mutant pku338, confirming that furina is responsible for the loft mutant phenotypes. Mechanistic studies demonstrated that Notch reporter Tg(tp1:mCherry) signals were largely eliminated in mutant hearts, while over-expression of NICD partially rescued the mutant phenotypes, probably due to the lack of Furina-mediated cleavage processing of Notch1b proteins, the only Notch receptor expressed in the heart. Together, our data suggest a potential post-translational modification of Notch1b proteins via the proprotein convertase Furina in the heart and unveil the function of the Furina-Notch1b axis in cardiac looping and trabeculation in zebrafish and possibly in other organisms.

Cardiac looping and laterality

2018 ◽  
Author(s):  
Marina Campione ◽  
Amelia Aranega ◽  
Diego Franco
Keyword(s):  
Current Data ◽  
Cardiac Looping ◽  
Downstream Target ◽  
Morphological Asymmetry ◽  
Proper Form ◽  
Signalling Molecule ◽  
Pitx2 Gene ◽  
Homeobox Transcription Factor ◽  
And Function

Dextral looping is a complex process which progresses concomitantly with cardiac chamber differentiation and ultimately leads to the final alignment of the cardiac regions. Generation of cardiac asymmetry is crucial to ensure the proper form and consequent function of the heart and thus is a highly regulated process. Molecular signals originate long before morphological asymmetry and therefore can direct it; a complex regulatory network has been characterized which invariably converges on the Tgf-β‎ signalling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2. We review current data regarding the cellular and molecular bases of cardiac looping and laterality, and describe current understaning of the role of Nodal and Pitx2. The morphogenetic role of the Pitx2 gene and its modulation of transcription and function, which have recently linked laterality to atrial fibrillation, are emphasized.

scholarly journals A Constitutive Mutation ofALK5Disrupts Cardiac Looping and Morphogenesis in Mice

1998 ◽  
Vol 202 (2) ◽  
pp. 315 ◽  
Author(s):  
Min-Ji Charng ◽  
Peter A. Frenkel ◽  
Qing Lin ◽  
Miho Yamada ◽  
Robert J. Schwartz ◽  
...  
Keyword(s):  
Cardiac Looping ◽  
Constitutive Mutation

scholarly journals Shortened Outflow Tract Leads to Altered Cardiac Looping After Neural Crest Ablation

Circulation ◽  
2002 ◽  
Vol 106 (4) ◽  
pp. 504-510 ◽  
Author(s):  
T. Mesud Yelbuz ◽  
Karen L. Waldo ◽  
Donna H. Kumiski ◽  
Harriett A. Stadt ◽  
Raymond R. Wolfe ◽  
...  
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Looping
Sign in / Sign up

Export Citation Format

Share Document