Morphogenetic control of zebrafish cardiac looping by Bmp signaling

Verónica A. Lombardo; Melina Heise; Motahareh Moghtadaei; Dorothee Bornhorst; Jörg Männer; Salim Abdelilah-Seyfried

doi:10.1242/dev.180091

Morphogenetic control of zebrafish cardiac looping by Bmp signaling

Development ◽

10.1242/dev.180091 ◽

2019 ◽

Vol 146 (22) ◽

pp. dev180091 ◽

Cited By ~ 5

Author(s):

Verónica A. Lombardo ◽

Melina Heise ◽

Motahareh Moghtadaei ◽

Dorothee Bornhorst ◽

Jörg Männer ◽

...

Keyword(s):

Bmp Signaling ◽

Cardiac Looping

BMP Signaling Pathways in Cartilage and Bone Formation

Critical Reviews in Eukaryotic Gene Expression ◽

10.1615/critreveukargeneexpr.v11.i1-3.20 ◽

2001 ◽

Vol 11 (1-3) ◽

pp. 24 ◽

Cited By ~ 66

Author(s):

Andrea Hoffmann ◽

Gerhard Gross

Keyword(s):

Bone Formation ◽

Signaling Pathways ◽

Bmp Signaling

Faculty Opinions recommendation of The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1003827.39604 ◽

2002 ◽

Author(s):

Caroline Hill

Keyword(s):

Bmp Signaling ◽

Ubiquitin Protein Ligase ◽

Drosophila Embryogenesis

Faculty Opinions recommendation of Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1013092.191555 ◽

2003 ◽

Author(s):

Lilianna Solnica-Krezel

Keyword(s):

Negative Feedback ◽

Bmp Signaling ◽

Feedback Regulator

Faculty Opinions recommendation of Endofin acts as a Smad anchor for receptor activation in BMP signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087876.540811 ◽

2007 ◽

Author(s):

Matthew Seaman

Keyword(s):

Receptor Activation ◽

Bmp Signaling

Faculty Opinions recommendation of BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1108862.566008 ◽

2008 ◽

Author(s):

Manabu Ohyama ◽

Tetsuro Kobayashi

Keyword(s):

Hair Follicle ◽

Dermal Papilla ◽

Bmp Signaling ◽

Dermal Papilla Cells

Faculty Opinions recommendation of BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1927959.1482057 ◽

2010 ◽

Author(s):

Ralf Paus

Keyword(s):

Gene Expression ◽

Human Keratinocytes ◽

Bmp Signaling ◽

Cell Type ◽

Cell Type Specific

Faculty Opinions recommendation of Balancing BMP signaling through integrated inputs into the Smad1 linker.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718009475.793476526 ◽

2013 ◽

Author(s):

Jeff Wrana

Keyword(s):

Bmp Signaling

Faculty Opinions recommendation of Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725388769.793507218 ◽

2015 ◽

Author(s):

Ivan Martin ◽

Chiara Stüdle

Keyword(s):

Articular Cartilage ◽

Bmp Signaling ◽

Cartilage Differentiation

Faculty Opinions recommendation of An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726330829.793518908 ◽

2016 ◽

Author(s):

Chaya Kalcheim

Keyword(s):

Neural Crest ◽

Neural Tube ◽

Bmp Signaling ◽

Neural Tube Closure ◽

Signaling Axis ◽

Axis Extension ◽

Tube Closure ◽

Anterior Posterior ◽

Anterior Posterior Axis

Mechanism of CK2.3, a Novel Mimetic Peptide of Bone Morphogenetic Protein Receptor Type IA, Mediated Osteogenesis

International Journal of Molecular Sciences ◽

10.3390/ijms20102500 ◽

2019 ◽

Vol 20 (10) ◽

pp. 2500 ◽

Cited By ~ 3

Author(s):

Vrathasha Vrathasha ◽

Hilary Weidner ◽

Anja Nohe

Keyword(s):

Signaling Pathways ◽

Treatment Options ◽

Time Frame ◽

Bmp Signaling ◽

C2c12 Cells ◽

Molecular Sequence ◽

Sequence Of Events ◽

Protein Receptor

Background: Osteoporosis is a degenerative skeletal disease with a limited number of treatment options. CK2.3, a novel peptide, may be a potential therapeutic. It induces osteogenesis and bone formation in vitro and in vivo by acting downstream of BMPRIA through releasing CK2 from the receptor. However, the detailed signaling pathways, the time frame of signaling, and genes activated remain largely unknown. Methods: Using a newly developed fluorescent CK2.3 analog, specific inhibitors for the BMP signaling pathways, Western blot, and RT-qPCR, we determined the mechanism of CK2.3 in C2C12 cells. We then confirmed the results in primary BMSCs. Results: Using these methods, we showed that CK2.3 stimulation activated OSX, ALP, and OCN. CK2.3 stimulation induced time dependent release of CK2β from BMPRIA and concurrently CK2.3 colocalized with CK2α. Furthermore, CK2.3 induced BMP signaling depends on ERK1/2 and Smad1/5/8 signaling pathways. Conclusion: CK2.3 is a novel peptide that drives osteogenesis, and we detailed the molecular sequence of events that are triggered from the stimulation of CK2.3 until the induction of mineralization. This knowledge can be applied in the development of future therapeutics for osteoporosis.