Alternative RNA Splicing of Calcitonin/Calcitonin Gene-Related Peptide Minigene Transcripts in a Thyroid C-Cell Line

1994 ◽  
Vol 200 (2) ◽  
pp. 993-998 ◽  
Author(s):  
G.J. Cote
Keyword(s):  
Cell Line ◽  
Rna Splicing ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
C Cell ◽  
Calcitonin Gene

Identification of High Affinity Calcitonin Gene?Related Peptide Receptors on a Murine Macrophage-like Cell Line

1990 ◽  
Vol 594 (1 Neuropeptides) ◽  
pp. 364-366 ◽  
Author(s):  
J. ABELLO ◽  
D. KAISERLIAN-NICOLAS ◽  
J. C. CUBER ◽  
J. P. REVILLARD ◽  
J. A. CHAYVIALLE
Keyword(s):  
Cell Line ◽  
Calcitonin Gene Related Peptide ◽  
Murine Macrophage ◽  
Peptide Receptors ◽  
High Affinity ◽  
Related Peptide ◽  
Calcitonin Gene

Structure-activity relationships in calcitonin gene-related peptide: Cyclic AMP response in a preosteoblast cell line (ks-4)

2009 ◽  
Vol 6 (10) ◽  
pp. 1137-1142 ◽  
Author(s):  
Daniel Thiebaud ◽  
Takuhiko Akatsu ◽  
Takeyoshi Yamashita ◽  
Tatsuo Suda ◽  
Toshiharu Noda ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cell Line ◽  
Calcitonin Gene Related Peptide ◽  
Structure Activity Relationships ◽  
Related Peptide ◽  
Structure Activity ◽  
Calcitonin Gene

A role for calcitonin gene related peptide (CGRP) in the regulation of early B lymphocyte differentiation

1995 ◽  
Vol 73 (7) ◽  
pp. 1057-1064 ◽  
Author(s):  
Joseph P. McGillis ◽  
Vidya Rangnekar ◽  
John R. Ciallella
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
Cell Line ◽  
Inhibitory Effect ◽  
Calcitonin Gene Related Peptide ◽  
Mouse Bone Marrow ◽  
B Cell Differentiation ◽  
Mobility Shift ◽  
Related Peptide ◽  
Calcitonin Gene

In previous studies we identified high affinity adenylyl cyclase linked receptors for calcitonin gene related peptide (CGRP) on rat T and B cells, on lymphocyte cell lines including the mouse pre-B cell line 70Z/3, and on cells in mouse bone marrow. The effect of CGRP on early B cell differentiation has been examined using the 70Z/3 cell line. CGRP inhibits the lipopolysaccharide (LPS) induction of surface immunoglobulin (sIg) protein expression in 70Z/3 cells, an effect that is associated with a decrease in the steady-state levels of Ig heavy (μ) and light (κ) chain mRNA. In this report, experiments are described that provide further information on the mechanism by which CGRP inhibits sIg expression. The kinetics of CGRP inhibition of LPS-induced sIg expression was examined in 70Z/3 cells. An optimal window for the inhibitory effect of CGRP on sIg induction occurs at least 24 h after the cells are treated with LPS. To determine whether the inhibitory effects of CGRP on sIg expression are mediated by an inhibition of NFκ-B translocation to the nucleus, electrophoretic mobility shift assays were performed using nuclear proteins from 70Z/3 cells. There was no difference in NFκ-B binding activity in cells that had been treated with LPS or LPS + CGRP, suggesting that the inhibitory effect of CGRP is not mediated by an inhibition of NFκ-B activity. These studies provide further evidence that CGRP plays an inhibitory role in early B cell differentiation. Finally, a model is proposed that describes an integrated role for CGRP in the homeostatic regulation of early B cell differentiation.Key words: neuropeptides, immune, immunoglobulin, neuroimmunology, calcitonin gene related peptides.

scholarly journals The Expression of mRNA for Calcitonin Gene-Related Peptide Receptors in a Mucosal Type Mast Cell Line, RBL-2H3

2004 ◽  
Vol 27 (6) ◽  
pp. 896-898 ◽  
Author(s):  
Yuki Kitabatake ◽  
Shunsuke Kawamura ◽  
Masamichi Yamashita ◽  
Kaori Okuyama ◽  
Motoaki Takayanagi ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Receptors ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Mast Cell Line
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