Expression of Vascular Endothelial Growth Factor at the Human Gastric Ulcer Margin and in Cultured Gastric Fibroblasts: A New Angiogenic Factor for Gastric Ulcer Healing

Angiogenesis is crucial to all types of wound healing, including gastric ulcer healing. The most potent promoter of angiogenesis is vascular endothelial growth factor (VEGF). We hypothesized that a 15-amino acid peptide designed to mimic the angiogenic action of VEGF would accelerate gastric ulcer healing. Gastric ulcers were induced in mice by serosal application of acetic acid. Treatment with the VEGF mimetic accelerated gastric ulcer healing when administered orally or intraperitoneally, at a dose of 50 ng/kg or greater. Such healing was not observed when the reverse sequence pentadecapeptide or the full-length VEGF protein was administered. Contrary to our hypothesis, the VEGF mimetic did not significantly increase angiogenesis in the ulcerated stomach. The enhancement of ulcer healing by the VEGF mimetic occurred independently of cyclooxygenase-2 (COX-2) activity but was blocked by inhibitors of inducible nitric oxide synthase (iNOS). These results demonstrate that a VEGF mimetic is a potent stimulus for gastric ulcer healing, even when given orally. The effects of the mimetic were independent of stimulatory effects on angiogenesis and COX-2 activity but were dependent on iNOS-derived NO production.

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Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.111150798 ◽

2001 ◽

Vol 98 (11) ◽

pp. 6470-6475 ◽

Cited By ~ 156

Author(s):

L. Ma ◽

S. N. Elliott ◽

G. Cirino ◽

A. Buret ◽

L. J. Ignarro ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Gastric Ulcer ◽

Growth Factor ◽

Ulcer Healing ◽

Vascular Endothelial ◽

Gastric Ulcer Healing ◽

Growth Factor Release ◽

Endothelial Growth Factor ◽

Factor Release

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Helicobacter pylori Down-Regulates the Receptors of Vascular Endothelial Growth Factor and Angiopoietin in Vascular Endothelial Cells: Implications in the Impairment of Gastric Ulcer Healing

Digestive Diseases and Sciences ◽

10.1023/b:ddas.0000030089.76514.e4 ◽

2004 ◽

Vol 49 (5) ◽

pp. 778-786 ◽

Cited By ~ 9

Author(s):

Joo Sung Kim ◽

Jung Mogg Kim ◽

Hyun Chae Jung ◽

In Sung Song

Keyword(s):

Vascular Endothelial Growth Factor ◽

Endothelial Cells ◽

Helicobacter Pylori ◽

Gastric Ulcer ◽

Growth Factor ◽

Ulcer Healing ◽

Vascular Endothelial Cells ◽

Vascular Endothelial ◽

Gastric Ulcer Healing ◽

Endothelial Growth Factor

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Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Biomolecules ◽

10.3390/biom11020253 ◽

2021 ◽

Vol 11 (2) ◽

pp. 253

Author(s):

Xi Guo ◽

Hong Yi ◽

Tin Chiu Li ◽

Yu Wang ◽

Huilin Wang ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Recurrent Miscarriage ◽

Embryo Implantation ◽

Critical Role ◽

Angiogenic Factor ◽

Vascular Endothelial ◽

Underlying Mechanisms ◽

Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.

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