NMR Studies on Novel Antitumor Drug Candidates, Deoxoartemisinin and Carboxypropyldeoxoartemisinin

2000 ◽  
Vol 274 (2) ◽  
pp. 359-369 ◽  
Author(s):  
Chang-Hun Lee ◽  
Heedouk Hong ◽  
Joon Shin ◽  
Mankil Jung ◽  
Injae Shin ◽  
...  
Keyword(s):  
Antitumor Drug ◽  
Nmr Studies ◽  
Drug Candidates

Electrochemistry and bioactivity relationship of 6-substituted-4H-Pyrido[4,3,2-kl]acridin-4-one antitumor drug candidates

2012 ◽  
Vol 88 ◽  
pp. 103-109 ◽  
Author(s):  
Laurent Bouffier ◽  
Isabelle Gosse ◽  
Martine Demeunynck ◽  
Pascal Mailley
Keyword(s):  
Antitumor Drug ◽  
Drug Candidates ◽  
Relationship Of

Selected polyoxopalladates as promising and selective antitumor drug candidates

2021 ◽  
Author(s):  
Andjelka M. Isakovic ◽  
Mirjana B. Čolović ◽  
Tian Ma ◽  
Xiang Ma ◽  
Marija Jeremic ◽  
...  
Keyword(s):  
Antitumor Drug ◽  
Drug Candidates

Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates

2016 ◽  
Vol 77 ◽  
pp. 14-19 ◽  
Author(s):  
Ana Marisa Chudzinski-Tavassi ◽  
Katia L.P. Morais ◽  
Mário Thiego Fernandes Pacheco ◽  
Kerly Fernanda Mesquita Pasqualoto ◽  
Jean Gabriel de Souza
Keyword(s):  
Salivary Gland ◽  
Antitumor Drug ◽  
Natural Source ◽  
Drug Candidates

scholarly journals Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5667
Author(s):  
Ming-Shu Wang ◽  
Yi Gong ◽  
Zhi-Cheng Yu ◽  
Yan-Guang Tian ◽  
Lin-Sheng Zhuo ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Grignard Reagent ◽  
Antitumor Drug ◽  
Grignard Reagents ◽  
Synthetic Route ◽  
Preclinical Development ◽  
Drug Candidates ◽  
Wide Range

A robust, practical, and scalable approach for the construction of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives 13 via the addition of Grignard reagents to 4-amino-2-chloronicotinonitrile (15) was developed. Starting with various Grignard reagents, a wide range of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives 13 were conveniently synthesized in moderate-to-good yields through addition–acidolysis–cyclocondensation. In addition, the robustness and applicability of this synthetic route was proven on a 100 g scale, which would enable convenient sample preparation in the preclinical development of 1,6-naphthyridin-4-one-based MET-targeting antitumor drug candidates.

scholarly journals Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets

Acta Naturae ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 4-15
Author(s):  
Alexandra V. Bruter ◽  
Mariya D. Rodionova ◽  
Ekaterina A. Varlamova ◽  
Alexander A. Shtil
Keyword(s):  
Protein Kinases ◽  
Gene Transcription ◽  
Antitumor Drug ◽  
Elevated Concentration ◽  
Cyclin Dependent Kinases ◽  
Pharmacological Inhibition ◽  
Drug Candidates ◽  
Novel Targets ◽  
General Aspects ◽  
Activate Gene

Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are regarded as novel targets for pharmacological inhibition by antitumor drug candidates.

scholarly journals NMR studies on the binding of antitumor drug nogalamycin to DNA hexamer d(CGTACG)

1990 ◽  
Vol 18 (16) ◽  
pp. 4851-4858 ◽  
Author(s):  
Howard Robinson ◽  
Yen-Chywan Liaw ◽  
Gijs A. van der Marel ◽  
Jacques H. van Boom ◽  
Andrew H.-J. Wang
Keyword(s):  
Antitumor Drug ◽  
Nmr Studies

NMR studies of the R2 repeat and related peptide fragments of the DNA binding domain of c-Myb. New light on the structure and folding of R2.

1999 ◽  
Vol 96 (9/10) ◽  
pp. 1580-1584 ◽  
Author(s):  
I. Ségalas ◽  
S. Desjardins ◽  
H. Oulyadi ◽  
Y. Prigent ◽  
S. Tribouillard ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Peptide Fragments ◽  
Nmr Studies ◽  
Related Peptide

2D NMR studies on muscle and cerebral metabolism in vivo

1994 ◽  
Vol 91 ◽  
pp. 697-703 ◽  
Author(s):  
B Gillet ◽  
BT Doan ◽  
C Verre-Sebrie ◽  
O Fedeli ◽  
JC Beloeil ◽  
...  
Keyword(s):  
Cerebral Metabolism ◽  
2D Nmr ◽  
Nmr Studies
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