Characterization of in Vivo Mutated T Cell Clones from Patients with Systemic Lupus Erythematosus

1995 ◽  
Vol 74 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Stamatios Theocharis ◽  
Petros P. Sfikakis ◽  
Robert N. Lipnick ◽  
Gary L. Klipple ◽  
Alfred D. Steinberg ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
T Cell Clones ◽  
Cell Clones

TCRBV-family expression among HPRT mutant T cell clones from patients with systemic lupus erythematosus

1997 ◽  
Vol 56 ◽  
pp. 363
Author(s):  
I.W.H.M. Maas ◽  
H.M. Schoemaker ◽  
R.H.W.M. Derksen ◽  
G.T. Spierenburg ◽  
F.H.J. Gmelig-Meyling
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
T Cell Clones ◽  
Cell Clones

Immunophenotype and cytokine production of HPRT mutant T cell clones from patients with systemic lupus erythematosus

1997 ◽  
Vol 56 ◽  
pp. 459
Author(s):  
F.H.J. Gmelig-Meyling ◽  
I.W.H.M. Maas ◽  
G.T. Spierenburg ◽  
H.M. Schoemaker ◽  
L. Kater ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Cytokine Production ◽  
Systemic Lupus ◽  
T Cell Clones ◽  
Cell Clones

Characterization of in vivo expanded OspA-specific human T-cell clones☆

2005 ◽  
Vol 115 (3) ◽  
pp. 313-322 ◽  
Author(s):  
L AUSUBEL ◽  
K OCONNOR ◽  
C BAECHERALLEN ◽  
C TROLLMO ◽  
B KESSLER ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

scholarly journals Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus.

1992 ◽  
Vol 175 (1) ◽  
pp. 297-300 ◽  
Author(s):  
F Gmelig-Meyling ◽  
S Dawisha ◽  
A D Steinberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Blood Lymphocytes

The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC among cells from SLE patients appears to reflect excessive in vivo activation and proliferation during the course of the disease. This represents the first demonstration of such a T cell abnormality in SLE; it supports the hypothesis that SLE T cells demonstrate increased in vivo division and/or survival.

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