Activation of Human Monocyte-Derived Macrophages by Immune Complexes Containing Low-Density Lipoprotein

1995 ◽  
Vol 75 (2) ◽  
pp. 179-189 ◽  
Author(s):  
Gabriel Virella ◽  
José F. Muñoz ◽  
Gillian M.P. Galbraith ◽  
Christoph Gissinger ◽  
Charlene Chassereau ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Monocyte ◽  
Low Density

scholarly journals Metabolism of Hyperoxydised Low Density Lipoprotein by Human Monocyte-Derived Macrophage

1987 ◽  
Vol 15 (5) ◽  
pp. 1097-1100 ◽  
Author(s):  
Akira HIBINO ◽  
Susumu YUKAWA ◽  
Takao MAEDA ◽  
Hiroshi NOMOTO
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Monocyte ◽  
Low Density

scholarly journals Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content

1991 ◽  
Vol 278 (2) ◽  
pp. 429-434 ◽  
Author(s):  
V M Darley-Usmar ◽  
A Severn ◽  
V J O'Leary ◽  
M Rogers
Keyword(s):  
Oxidized Ldl ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Monocyte ◽  
Cell Types ◽  
Oxidative Modification ◽  
Glutathione Depletion ◽  
Lipid Phase ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

Macrophages derived from the human monocyte cell line THP-1 or isolated from the peritoneum of C3H/HEJ mice were incubated with oxidized low-density lipoprotein (LDL) and the total glutathione content (oxidized plus reduced) was measured. An initial depletion of glutathione was followed by an increase, such that after a period of 24 h the glutathione content has approximately doubled. This response required the oxidation of the lipid phase of the LDL molecule, since both native LDL and acetylated LDL had little effect on glutathione levels. The response of the cells to oxidized LDL was dependent on the extent of oxidative modification of the protein. It was also found that 4-hydroxynonenal had a similar effect on THP-1 cells, and we suggest that this or other aldehydes present in oxidized LDL causes the induction of glutathione synthesis in response to an initial oxidative stress and consequent glutathione depletion. In addition, we found that both cell types possess transferases and peroxidases capable of detoxifying aldehydes and peroxides. However, treatment of cells with oxidized LDL or 4-hydroxynonenal for a period of 24 h had no effect on the activities of these enzymes.

Oxidation of Low-Density Lipoprotein by Human Monocyte-Macrophages Results in Toxicity to the Oxidising Culture

1996 ◽  
Vol 24 (5) ◽  
pp. 333-342 ◽  
Author(s):  
Christine E. Marchant ◽  
Carina Van Der Wen ◽  
Nadine S. Law ◽  
Simon J. Hardwick ◽  
Ken L.H. Carpenter ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Monocyte ◽  
Low Density

Glucose-Modified Low Density Lipoprotein Enhances Human Monocyte Chemotaxis

1998 ◽  
Vol 28 (5) ◽  
pp. 533-542 ◽  
Author(s):  
Stephanie A. Millican ◽  
Donna Schultz ◽  
Meena Bagga ◽  
Peter J. Coussons ◽  
Karin Müller ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Monocyte ◽  
Low Density ◽  
Monocyte Chemotaxis
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