Activation of Skeletal Muscle Satellite Cells and the Role of Fibroblast Growth Factor Receptors

1995 ◽  
Vol 219 (2) ◽  
pp. 449-453 ◽  
Author(s):  
Sally E. Johnson ◽  
Ronald E. Allen
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Satellite Cells ◽  
Growth Factor Receptors ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors ◽  
Muscle Satellite Cells ◽  
Skeletal Muscle Satellite Cells

MP52-18 ROLE OF FIBROBLAST GROWTH FACTOR RECEPTORS IN LEYDIG CELL DEVELOPMENT

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Andres Correa ◽  
Kenneth Walker ◽  
Daniel Bushnel ◽  
Caitlin Schaefer ◽  
Julia Schaffer ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Leydig Cell ◽  
Growth Factor Receptors ◽  
Cell Development ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors

Role of fibroblast growth factor receptors in esophageal squamous cell carcinoma

Esophagus ◽  
2015 ◽  
Vol 13 (1) ◽  
pp. 30-41
Author(s):  
Yutaka Shimada ◽  
Tomoyuki Okumura ◽  
Yoshinori Takei ◽  
Kazuaki Watanabe ◽  
Takuya Nagata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Fibroblast Growth Factor ◽  
Squamous Cell ◽  
Growth Factor Receptors ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors

Developmental expression of two murine fibroblast growth factor receptors, flg and bek

Development ◽  
1991 ◽  
Vol 113 (4) ◽  
pp. 1419-1434 ◽  
Author(s):  
A. Orr-Urtreger ◽  
D. Givol ◽  
A. Yayon ◽  
Y. Yarden ◽  
P. Lonai
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Growth Factor Receptors ◽  
Limb Bud ◽  
Developmental Expression ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors ◽  
Surface Ectoderm ◽  
Murine Fibroblast

Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.

Distinct developmental expression of a new avian fibroblast growth factor receptor

Development ◽  
1994 ◽  
Vol 120 (3) ◽  
pp. 683-694 ◽  
Author(s):  
C. Marcelle ◽  
A. Eichmann ◽  
O. Halevy ◽  
C. Breant ◽  
N.M. Le Douarin
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Satellite Cells ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Primitive Streak ◽  
Developmental Expression ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors

We have cloned a new member of the fibroblast growth factor receptor family from avian embryonic RNA. The FREK (for fibroblast growth factor receptor-like embryonic kinase) primary transcript can be alternatively spliced in a tissue- and stage-specific manner to give rise to molecules containing either two or three Ig-like domains. During elongating primitive streak stages, FREK is expressed in the rostral and lateral epiblast and in the Hensen's node. From 2.5 days of development (E 2.5) on, it is expressed in various ectoderm- and mesoderm-derived structures. Most striking is FREK expression in the skeletal muscle lineage. It is highly expressed in the early myotome and, at later stages, in all skeletal muscles of the embryo. From E9 to hatching, FREK expression in the muscles decreases dramatically but is maintained in satellite cells of adult muscles. FREK transcript is elevated upon addition of basic fibroblast growth factor to serum-starved satellite cells. From this study, we conclude: (1) that the structure and pattern of expression of FREK set it apart from other cloned fibroblast growth factor receptors (FGFR) and suggest that FREK is a new member of that family; (2) that FREK may play multiple roles in early avian development, including a specialized role in the early differentiation of skeletal muscle.

Sign in / Sign up

Export Citation Format

Share Document