Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells

2001 ◽  
Vol 70 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Frank A. Seebach ◽  
Thomas Welte ◽  
Xin-Yuan Fu ◽  
Lutz-Henning Block ◽  
Michael Kashgarian
Keyword(s):  
Angiotensin Ii ◽  
Mesangial Cells ◽  
Differential Activation ◽  
Angiotensin Type ◽  
Stat Pathway

scholarly journals Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

Hypertension ◽  
2006 ◽  
Vol 47 (3) ◽  
pp. 537-544 ◽  
Author(s):  
Shetal H. Padia ◽  
Nancy L. Howell ◽  
Helmy M. Siragy ◽  
Robert M. Carey
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Iii ◽  
Angiotensin Type

scholarly journals Imbalance of Angiotensin Type 1 Receptor and Angiotensin II Type 2 Receptor in the Rostral Ventrolateral Medulla

Hypertension ◽  
2008 ◽  
Vol 52 (4) ◽  
pp. 708-714 ◽  
Author(s):  
Lie Gao ◽  
Wei-Zhong Wang ◽  
Wei Wang ◽  
Irving H. Zucker
Keyword(s):  
Angiotensin Ii ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Angiotensin Type

scholarly journals Angiotensin II regulates migration in mouse cultured mesangial cells: evidence for the presence of receptor subtype-specific regulation

2006 ◽  
Vol 191 (2) ◽  
pp. 361-367 ◽  
Author(s):  
Yuichiro Takeuchi ◽  
Keishi Yamauchi ◽  
Junko Nakamura ◽  
Satoshi Shigematsu ◽  
Kiyoshi Hashizume
Keyword(s):  
Angiotensin Ii ◽  
Mesangial Cells ◽  
Biological Effects ◽  
Receptor Subtype ◽  
Cell Numbers ◽  
High Concentrations ◽  
Specific Regulation

The biological effects of angiotensin II (AngII) are mediated by two major subtypes of AngII receptors, type 1 (AT1R) and type 2 (AT2R). In this study, we attempted to elucidate the role of AngII subtype receptor-specific regulation in migration and proliferation of mouse cultured mesangial (MSG) cells. We found that 100 nM AngII stimulated weak migration of MSG cells. Cell motility increased more in the presence of AT2R than in the presence of AT1R, and it was suppressed by guanylate cyclase inhibitors. On the other hand, the activation of AT1R resulted in increased cell numbers, while AT2R activation inhibited cell proliferation. Moreover, high concentrations of glucose (25 mM) stimulated the expression of AT2R but not AT1R. These results indicate that there are receptor subtype-specific roles in MSG cells, and it is therefore possible that the activation of AT2R stimulates repair of glomerular tissue defect, by regulation of migration and proliferation of MSG cells. Taken together, these results suggest that the relative concentrations of AT1R and AT2R are important factors in the regulation of AngII function in glomerular tissue, and alterations in the concentrations of these receptors may contribute to progression of or protection from diabetic nephropathy.

scholarly journals Role of Angiotensin Type-1 and Angiotensin Type-2 Receptors in the Expression of Vascular Integrins in Angiotensin II–Infused Rats

Hypertension ◽  
2006 ◽  
Vol 47 (1) ◽  
pp. 122-127 ◽  
Author(s):  
Pascal Brassard ◽  
Farhad Amiri ◽  
Gaétan Thibault ◽  
Ernesto L. Schiffrin
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Type

Blockade of central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl intake in rats

1996 ◽  
Vol 66 (1-2) ◽  
pp. 47-50 ◽  
Author(s):  
O. Galaverna ◽  
C. Polidori ◽  
R.R. Sakai ◽  
F. Liénard ◽  
S.Y. Chow ◽  
...  
Keyword(s):  
Angiotensin Ii
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