The Transcription Factor E2F-1 in SV40 T Antigen-Induced Cerebellar Purkinje Cell Degeneration

1998 ◽  
Vol 12 (1-2) ◽  
pp. 16-28 ◽  
Author(s):  
Maria C. Athanasiou ◽  
Wael Yunis ◽  
Natalie Coleman ◽  
Robert Ehlenfeldt ◽  
H.Brent Clark ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Purkinje Cell ◽  
T Antigen ◽  
Cerebellar Purkinje Cell ◽  
Sv40 T Antigen ◽  
Cell Degeneration ◽  
Purkinje Cell Degeneration ◽  
Transcription Factor E2f

scholarly journals Cerebellar Purkinje cell degeneration in a mule foal ( Equus mulus mulus )

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Anna Suñol ◽  
Julia Sanmarti Fierro ◽  
Greta Foiani ◽  
Carles Morales ◽  
Patricia Montoliu
Keyword(s):  
Purkinje Cell ◽  
Cerebellar Purkinje Cell ◽  
Cell Degeneration ◽  
Purkinje Cell Degeneration

scholarly journals Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor

2014 ◽  
Vol 111 (31) ◽  
pp. 11521-11526 ◽  
Author(s):  
C. Long ◽  
C. E. Grueter ◽  
K. Song ◽  
S. Qin ◽  
X. Qi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Purkinje Cell ◽  
Cell Degeneration ◽  
Purkinje Cell Degeneration

scholarly journals Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 ◽  
Vol 12 (12) ◽  
pp. 5620-5631 ◽  
Author(s):  
B Shan ◽  
X Zhu ◽  
P L Chen ◽  
T Durfee ◽  
Y Yang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mammalian Cells ◽  
Leucine Zipper ◽  
T Antigen ◽  
Transactivation Domain ◽  
Recognition Sequence ◽  
Cellular Genes ◽  
Genes Encoding ◽  
Associated Proteins ◽  
Transcription Factor E2f

The retinoblastoma protein interacts with a number of cellular proteins to form complexes which are probably crucial for its normal physiological function. To identify these proteins, we isolated nine distinct clones by direct screening of cDNA expression libraries using purified RB protein as a probe. One of these clones, Ap12, is expressed predominantly at the G1-S boundary and in the S phase of the cell cycle. The nucleotide sequence of Ap12 has features characteristic of transcription factors. The C-terminal region binds to unphosphorylated RB in regions similar to those to which T antigen binds and contains a transactivation domain. A region containing a potential leucine zipper flanked by basic residues is able to bind an E2F recognition sequence specifically. Expression of Ap12 in mammalian cells significantly enhances E2F-dependent transcriptional activity. These results suggest that Ap12 encodes a protein with properties known to be characteristic of transcription factor E2F.

Purkinje cell degeneration elevates eupneic and hypercapnic ventilation in rats

2004 ◽  
Vol 3 (3) ◽  
pp. 133-140 ◽  
Author(s):  
Fadi Xu ◽  
Tongrong Zhou ◽  
Donald Frazier
Keyword(s):  
Purkinje Cell ◽  
Cell Degeneration ◽  
Purkinje Cell Degeneration
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