Investigation of Folate Pathway Gene Polymorphisms and the Incidence of Neural Tube Defects in a Texas Hispanic Population

2000 ◽  
Vol 70 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Robert Barber ◽  
Stuart Shalat ◽  
Kate Hendricks ◽  
Brigitte Joggerst ◽  
Russell Larsen ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Hispanic Population ◽  
Pathway Gene ◽  
Folate Pathway

Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China

2018 ◽  
Vol 34 (4) ◽  
pp. 725-729 ◽  
Author(s):  
Yulian Fang ◽  
Ruiping Zhang ◽  
Xiufang Zhi ◽  
Linsheng Zhao ◽  
Lirong Cao ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway ◽  
Gene Polymorphisms ◽  
Northern China ◽  
Han Population ◽  
Pathway Gene

Folate pathway gene alterations in patients with neural tube defects

2000 ◽  
Vol 95 (3) ◽  
pp. 216-223 ◽  
Author(s):  
Patrizia De Marco ◽  
Anna Moroni ◽  
Elisa Merello ◽  
Raffaella de Franchis ◽  
Luciano Andreussi ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Pathway Gene ◽  
Folate Pathway ◽  
Gene Alterations

scholarly journals Correction to: Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China

2018 ◽  
Vol 34 (4) ◽  
pp. 731-731
Author(s):  
Yulian Fang ◽  
Ruiping Zhang ◽  
Xiufang Zhi ◽  
Linsheng Zhao ◽  
Lirong Cao ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway ◽  
Gene Polymorphisms ◽  
Northern China ◽  
Han Population ◽  
Pathway Gene

Folate Pathway Enzyme Gene Polymorphisms and the Efficacy and Toxicity of Methotrexate in Psoriatic Arthritis

2010 ◽  
Vol 37 (7) ◽  
pp. 1508-1512 ◽  
Author(s):  
VINOD CHANDRAN ◽  
FOTIOS SIANNIS ◽  
PROTON RAHMAN ◽  
FAWNDA J. PELLETT ◽  
VERNON T. FAREWELL ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Side Effects ◽  
Gene Polymorphisms ◽  
Liver Toxicity ◽  
Fisher Exact Test ◽  
Dhfr Gene ◽  
Exact Test ◽  
Drug Survival ◽  
Pathway Gene ◽  
Folate Pathway

Objective.To determine the association between folate pathway gene polymorphisms and the effectiveness, toxicity, and drug survival of methotrexate (MTX) in psoriatic arthritis (PsA).Methods.Data were obtained from a longitudinal cohort of PsA patients evaluated according to a standard protocol. Data on duration of drug therapy, dose, side effects, and reasons for discontinuation are systematically recorded. Patients treated with MTX after clinic admission who had ≥ 3 swollen joints prior to initiating MTX therapy were selected for evaluation of effectiveness. Response to MTX treatment was assessed at 6 months. Data from all patients treated in the clinic with MTX were used in evaluation of toxicity and drug survival. The following single-nucleotide polymorphisms (SNP) were measured using the Sequenom platform: MTHFR 677C>T (rs1801133), MTHFR 1298A>C (rs1801131), DHFR −473T>C (rs1650697), DHFR 35289A>G (rs1232027), and RFC 80G>A (rs1051266). Fisher’s exact test, logistic regression, and Cox proportional hazard analyses were used to determine association.Results.Two hundred eighty-one patients were identified from the database. All patients were included in the analysis for side effects and drug survival, and 119 patients were included in the effectiveness analysis. The minor A allele of DHFR gene at +35289 was the only SNP demonstrating association with response to MTX therapy (OR 2.99, p = 0.02). Patients homozygous for the minor allele of MTHFR 677C/T (677TT) had more liver toxicity (Fisher exact test, p = 0.04).Conclusion.Polymorphisms of the DHFR gene may be associated with MTX efficacy. MTHFR 677TT may have a relationship with MTX-induced liver toxicity in PsA.

Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects

2009 ◽  
Vol 149A (7) ◽  
pp. 1585-1589 ◽  
Author(s):  
K. Doudney ◽  
J. Grinham ◽  
J. Whittaker ◽  
S.A. Lynch ◽  
D. Thompson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Folate Metabolism ◽  
Metabolism Gene

scholarly journals Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions

2006 ◽  
Vol 114 (10) ◽  
pp. 1547-1552 ◽  
Author(s):  
Abee L. Boyles ◽  
Ashley V. Billups ◽  
Kristen L. Deak ◽  
Deborah G. Siegel ◽  
Lorraine Mehltretter ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Association Tests ◽  
Gene Environment ◽  
Folate Pathway ◽  
Family Based

scholarly journals Is there more to folates than neural-tube defects?

2003 ◽  
Vol 62 (3) ◽  
pp. 591-598 ◽  
Author(s):  
Paul M. Finglas ◽  
Anthony J. A. Wright ◽  
Caroline A. Wolfe ◽  
David J. Hart ◽  
Dawn M. Wright ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Common Gene ◽  
Folate Status ◽  
Health And Disease ◽  
Precision And Accuracy ◽  
Folate Bioavailability ◽  
B Vitamin

The purpose of the present paper is to review our current understanding of the chemistry and biochemistry of folic acid and related folates, and to discuss their impact on public health beyond that already established in relation to neural-tube defects. Our understanding of the fascinating world of folates and C1metabolism, and their role in health and disease, has come a long way since the discovery of the B-vitamin folic acid by Wills (1931), and its first isolation by Mitchellet al. (1941). However, there is still much to do in perfecting methods for the measurement of folate bioavailability, and status, with a high extent of precision and accuracy. Currently, examination of the relationships between common gene polymorphisms involved in C1metabolism and folate bioavailability and folate status, morbidity, mortality and longevity is evaluated as a series of individual associations. However, in the future, examination of the concurrent effects of such common gene polymorphisms may be more beneficial.

Interaction between SNPs in folate pathway genes and environment increase neural tube defects risk

2014 ◽  
Vol 9 (4) ◽  
pp. 397-400
Author(s):  
Yunping Lei ◽  
Rachel K Tittle ◽  
Richard H Finnell
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Pathway ◽  
Genes And Environment

Association Study of PARD3 Gene Polymorphisms With Neural Tube Defects in a Chinese Han Population

2012 ◽  
Vol 19 (7) ◽  
pp. 764-771 ◽  
Author(s):  
Yonghui Gao ◽  
Xiaoli Chen ◽  
Shaofang Shangguan ◽  
Yihua Bao ◽  
Xiaoli Lu ◽  
...  
Keyword(s):  
Association Study ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children

2010 ◽  
Vol 29 (3) ◽  
pp. 116-123 ◽  
Author(s):  
Jason Yong-Sheng Chan ◽  
Dewa G Ugrasena ◽  
Danny Wai-Kiong Lum ◽  
Yi Lu ◽  
Allen Eng-Juh Yeoh
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Gene Polymorphisms ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Pathway Gene ◽  
Folate Pathway
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