Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China

2018 ◽  
Vol 34 (4) ◽  
pp. 725-729 ◽  
Author(s):  
Yulian Fang ◽  
Ruiping Zhang ◽  
Xiufang Zhi ◽  
Linsheng Zhao ◽  
Lirong Cao ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway ◽  
Gene Polymorphisms ◽  
Northern China ◽  
Han Population ◽  
Pathway Gene

scholarly journals Correction to: Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China

2018 ◽  
Vol 34 (4) ◽  
pp. 731-731
Author(s):  
Yulian Fang ◽  
Ruiping Zhang ◽  
Xiufang Zhi ◽  
Linsheng Zhao ◽  
Lirong Cao ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway ◽  
Gene Polymorphisms ◽  
Northern China ◽  
Han Population ◽  
Pathway Gene

Association Study of PARD3 Gene Polymorphisms With Neural Tube Defects in a Chinese Han Population

2012 ◽  
Vol 19 (7) ◽  
pp. 764-771 ◽  
Author(s):  
Yonghui Gao ◽  
Xiaoli Chen ◽  
Shaofang Shangguan ◽  
Yihua Bao ◽  
Xiaoli Lu ◽  
...  
Keyword(s):  
Association Study ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Investigation of Folate Pathway Gene Polymorphisms and the Incidence of Neural Tube Defects in a Texas Hispanic Population

2000 ◽  
Vol 70 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Robert Barber ◽  
Stuart Shalat ◽  
Kate Hendricks ◽  
Brigitte Joggerst ◽  
Russell Larsen ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Hispanic Population ◽  
Pathway Gene ◽  
Folate Pathway

Association of neural tube defects with gene polymorphisms in one-carbon metabolic pathway

2017 ◽  
Vol 34 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Lirong Cao ◽  
Yizheng Wang ◽  
Ruiping Zhang ◽  
Liang Dong ◽  
Hualei Cui ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway ◽  
Gene Polymorphisms

scholarly journals Gene-gene interaction between VANGL1, FZD3, and FZD6 correlated with neural tube defects in Han population of Northern China

2016 ◽  
Vol 15 (3) ◽  
Author(s):  
R.P. Zhang ◽  
Y.L. Fang ◽  
B. Wu ◽  
M.N. Chemban ◽  
N. Laakhey ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Interaction ◽  
Northern China ◽  
Han Population

scholarly journals Correlation analysis of MTHFD1 gene polymorphisms and neural tube defects in Han population of Northern China

2020 ◽  
Author(s):  
Yulian Fang ◽  
Yan Liu ◽  
Jian-Bo Shu ◽  
Lin-Sheng Zhao ◽  
Lu Wang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Harmful Effect ◽  
Northern China ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Han Population ◽  
Tag Snps ◽  
Hapmap Database

Abstract Background Neural tube defects (NTDs) is a common birth defects worldwide. The methylenetetrahydrofolate dehydrogenase1 (MTHFD1) gene has been proved to play an important role in folate metabolism, which was strongly associated with the increased NTDs risk. The study is aimed to explore the correlation of single nucleotide polymorphisms (SNPs) in MTHFD1 gene with NTDs susceptibility. Methods A case-control study was conducted on children who included 152 NTDs patients and 169 healthy controls. Tag-SNPs were identified in HapMap database. Then, we investigated the association between NTDs and four selected tag-SNPs in MTHFD1 gene: rs1950902, rs2236225, rs2236224, rs11849530. We also performed a meta-analysis based on previous published studies to further evaluate the association. Results The results indicated that rs2236225 polymorphism displayed a significant association with NTDs risk (AA vs. GG: OR = 2.862, 95%CI = 1.022ཞ8.015; GA + AA vs. GG: OR = 1.619, 95%CI = 1.040ཞ2.520; A vs. G: OR = 1.500, 95%CI = 1.061ཞ2.120). In addition, rs2236224 polymorphism was correlated with increased NTDs risk (TT vs. CC: OR = 2.559, 95%CI = 1.128ཞ5.804; CT + TT vs. CC; OR = 1.631, 95%CI = 1.041ཞ2.556; T vs C: OR = 1.489, 95%CI = 1.072ཞ2.068). Further analysis showed the harmful effect of rs2236225 polymorphism was further supported by the result of meta-analysis. Meanwhile, haplotype analysis results showed that A-A and T-A haplotypes were correlated with increased NTDs risk, but C-A haplotype might decrease NTDs risk. Conclusions The results indicated that rs2236225 and rs2236224 polymorphisms of MTHFD1 gene were significantly associated with NTDs susceptibility in Han population of Northern China.

Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China

Epidemiology ◽  
2011 ◽  
Vol 22 (4) ◽  
pp. 491-496 ◽  
Author(s):  
Rongwei Ye ◽  
Aiguo Ren ◽  
Le Zhang ◽  
Zhiwen Li ◽  
Jianmeng Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Northern China ◽  
Tea Drinking

scholarly journals Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Chun-Quan Cai ◽  
Yu-Lian Fang ◽  
Jian-Bo Shu ◽  
Lin-Sheng Zhao ◽  
Rui-Ping Zhang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway

Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects

2009 ◽  
Vol 149A (7) ◽  
pp. 1585-1589 ◽  
Author(s):  
K. Doudney ◽  
J. Grinham ◽  
J. Whittaker ◽  
S.A. Lynch ◽  
D. Thompson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Folate Metabolism ◽  
Metabolism Gene
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