ISOLATED CARDIAC CELLS FOR ELECTROPHARMACOLOGICAL STUDIES

2000 ◽  
Vol 42 (1) ◽  
pp. 1-8 ◽  
Author(s):  
ELISABETTA CERBAI ◽  
LAURA SARTIANI ◽  
PETRA DE PAOLI ◽  
ALESSANDRO MUGELLI
Keyword(s):  
Cardiac Cells ◽  
Isolated Cardiac Cells

Electrophysiology of the Sodium-Potassium-ATPase in Cardiac Cells

2001 ◽  
Vol 81 (4) ◽  
pp. 1791-1826 ◽  
Author(s):  
Helfried Günther Glitsch
Keyword(s):  
Cell Membrane ◽  
Potential Gradient ◽  
Outward Current ◽  
Pump Current ◽  
Cardiac Cells ◽  
Animal Cells ◽  
Excitable Cells ◽  
Extracellular Medium ◽  
Enzymatic Isolation ◽  
Isolated Cardiac Cells

Like several other ion transporters, the Na+-K+ pump of animal cells is electrogenic. The pump generates the pump current I p. Under physiological conditions, I p is an outward current. It can be measured by electrophysiological methods. These methods permit the study of characteristics of the Na+-K+ pump in its physiological environment, i.e., in the cell membrane. The cell membrane, across which a potential gradient exists, separates the cytosol and extracellular medium, which have distinctly different ionic compositions. The introduction of the patch-clamp techniques and the enzymatic isolation of cells have facilitated the investigation of I p in single cardiac myocytes. This review summarizes and discusses the results obtained from I p measurements in isolated cardiac cells. These results offer new exciting insights into the voltage and ionic dependence of the Na+-K+ pump activity, its effect on membrane potential, and its modulation by hormones, transmitters, and drugs. They are fundamental for our current understanding of Na+-K+ pumping in electrically excitable cells.

Development of a linear transient model for stimulation of isolated cardiac cells

2000 ◽  
Vol 12 (3) ◽  
pp. 217-222 ◽  
Author(s):  
P. Pham ◽  
G. Cauffet ◽  
A. Bardou ◽  
J. Olivares ◽  
E. Novakov
Keyword(s):  
Cardiac Cells ◽  
Transient Model ◽  
Isolated Cardiac Cells ◽  
Stimulation Of

scholarly journals The effect of TYB-3823, a new antiarrhythmic drug, on sodium current in isolated cardiac cells

1991 ◽  
Vol 104 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Jiro Miyamoto ◽  
Ichiro Hisatome ◽  
Satoshi Matsuoka ◽  
Hiromoto Kosaka ◽  
Yasutaka Kurata ◽  
...  
Keyword(s):  
Antiarrhythmic Drug ◽  
Sodium Current ◽  
Cardiac Cells ◽  
Isolated Cardiac Cells

Measurements of sarcomere dynamics simultaneously with auxotonic force in isolated cardiac cells

1993 ◽  
Vol 40 (12) ◽  
pp. 1226-1232 ◽  
Author(s):  
F. Gannier ◽  
J.C. Bernengo ◽  
V. Jacquemond ◽  
D. Garnier
Keyword(s):  
Cardiac Cells ◽  
Isolated Cardiac Cells ◽  
Sarcomere Dynamics
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