The Inhaled Administration of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, Prevents Antigen-induced Lung Inflammation in Guinea Pigs

2000 ◽  
Vol 13 (1) ◽  
pp. 5-11 ◽  
Author(s):  
H Manabe ◽  
K Akuta ◽  
H Kawasaki ◽  
K Ohmori
Keyword(s):  
Guinea Pigs ◽  
Lung Inflammation ◽  
Phosphodiesterase 4

The Protective Effect of α-Hederin, the Active Constituent of Nigella sativa , on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs

2015 ◽  
Vol 29 (11) ◽  
pp. 1761-1767 ◽  
Author(s):  
Rana Keyhanmanesh ◽  
Saeideh Saadat ◽  
Mostafa Mohammadi ◽  
Amir-Ali Shahbazfar ◽  
Maryam Fallahi
Keyword(s):  
Protective Effect ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Nigella Sativa ◽  
Active Constituent ◽  
Blood Cytokines

The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs

2016 ◽  
Vol 32 (12) ◽  
pp. 1971-1977 ◽  
Author(s):  
Zahra Gholamnezhad ◽  
Mohammad Hossein Boskabady ◽  
Sediqa Amery ◽  
Nassim Vahedi ◽  
Abass Tabatabaei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Pulmonary Complications ◽  
Control Group ◽  
Lung Pathology ◽  
Pathological Changes ◽  
Bronchial Stenosis ◽  
Pathological Evaluation

Pulmonary complications of exposure to sulfur mustard (SM) gas range from no effect or mild symptoms to severe bronchial stenosis. In the present study, the protective effect of vitamin E on the lung inflammation of SM-exposed guinea pigs was examined. Guinea pigs ( n = 5 for each group) were exposed to ethanol (control group), 40 mg/m3 inhaled SM (SME group), SME treated with vitamin E (SME + E), SME treated with dexamethasone (SME + D), and SME treated with both treatments (SME + E + D). Pathological evaluation of the lung was done 14 days postexposure. The epithelial desquamation of trachea and other pathologic changes in the lung of the SME group were significantly higher than those in the control group. Furthermore, the pathological changes of trachea and lung in the SME + E and SME + E + D groups were significantly improved compared with those of SME group. In addition, the pathological changes of trachea and lung of SME + E and SME + E + D animals were significantly less than those of SME + D group.

Evidence for the activation of blood complement in Sephadex beads-induced lung inflammation in guinea pigs

1999 ◽  
Vol 48 (7) ◽  
pp. 386-392 ◽  
Author(s):  
J.-F. Blain ◽  
K. Maghni ◽  
S. Pelletier ◽  
P. Sirois
Keyword(s):  
Guinea Pigs ◽  
Lung Inflammation

The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

2011 ◽  
Vol 23 (3) ◽  
pp. 157-165 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Sediqa Amery ◽  
Nassim Vahedi ◽  
Mohammad Reza Khakzad
Keyword(s):  
Vitamin E ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard
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