The Protective Effect of α-Hederin, the Active Constituent of Nigella sativa , on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs

2015 ◽  
Vol 29 (11) ◽  
pp. 1761-1767 ◽  
Author(s):  
Rana Keyhanmanesh ◽  
Saeideh Saadat ◽  
Mostafa Mohammadi ◽  
Amir-Ali Shahbazfar ◽  
Maryam Fallahi
Keyword(s):  
Protective Effect ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Nigella Sativa ◽  
Active Constituent ◽  
Blood Cytokines

scholarly journals The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs

2015 ◽  
Vol 65 (3) ◽  
pp. 285-292 ◽  
Author(s):  
Saeideh Saadat ◽  
Mostafa Mohammadi ◽  
Maryam Fallahi ◽  
Rana keyhanmanesh ◽  
Mohammad Reza Aslani
Keyword(s):  
Protective Effect ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Nigella Sativa ◽  
Active Constituent

The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats

2020 ◽  
Vol 253 ◽  
pp. 112653 ◽  
Author(s):  
Amin Mokhtari-Zaer ◽  
Fatemeh Norouzi ◽  
Vahid Reza Askari ◽  
Mohammad Reza Khazdair ◽  
Nama Mohammadian Roshan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Lung Inflammation ◽  
Nigella Sativa ◽  
And Oxidative Stress

THE PROTECTIVE EFFECT OF NIGELLA SATIVA ON LUNG INJURY OF SULFUR MUSTARD–EXPOSED GUINEA PIGS

2008 ◽  
Vol 34 (4) ◽  
pp. 183-194 ◽  
Author(s):  
Boskabady Mohammad Hossein ◽  
Vahedi Nasim ◽  
Amery Sediqa
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Guinea Pigs ◽  
Sulfur Mustard ◽  
Nigella Sativa

scholarly journals The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs

Clinics ◽  
2011 ◽  
Vol 66 (5) ◽  
pp. 879-887 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Rana Keyhanmanesh ◽  
Saeed Khamneh ◽  
Mohammad Ali Ebrahimi
Keyword(s):  
Guinea Pigs ◽  
Lung Inflammation ◽  
Nigella Sativa

The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

2011 ◽  
Vol 137 (2) ◽  
pp. 1028-1034 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Nassim Vahedi ◽  
Sediqa Amery ◽  
Mohammad Reza Khakzad
Keyword(s):  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Nigella Sativa

PARALLEL STUDIES OF COMPLEMENT AND BLOOD COAGULATION IX. THE EFFECT OF METHIONINE, CHOLINE, AND CYSTINE ON THE CHANGES INDUCED BY ETHIONINE

1953 ◽  
Vol 31 (4) ◽  
pp. 343-357
Author(s):  
Christine E. Rice ◽  
Paul Boulanger ◽  
P. J. G. Plummer ◽  
E. Annau
Keyword(s):  
Fatty Liver ◽  
Protective Effect ◽  
Blood Coagulation ◽  
Guinea Pigs ◽  
Acinar Cells ◽  
Complement Components ◽  
Fatty Livers

Fatty livers were produced in guinea pigs by the repeated feeding or injection of ethionine; the acinar cells of the pancreas were also affected in some of the animals. Marked changes in plasma coagulability always occurred as well as a definite reduction in complement titer in which two or more of the major complement components were involved. Methionine displayed some protective effect against the fatty liver induced by the ethionine and was partially effective in controlling the coagulative changes and the decline in complement titer. In some animals, choline likewise ameliorated these conditions, whereas cystine tended to aggravate them. A combination of cystine and choline was more effective than choline alone.

scholarly journals Protective effect of Nigella sativa oil on acoustic trauma induced hearing loss in rats

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Belde Culhaoglu ◽  
Selim S. Erbek ◽  
Seyra Erbek ◽  
Evren Hizal
Keyword(s):  
Hearing Loss ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Acoustic Trauma ◽  
Female Rats ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Study Group ◽  
Intensity Level ◽  
Hearing Thresholds

Acoustic trauma is a common reason for hearing loss. Different agents are used to prevent the harmful effect of acoustic trauma on hearing. The aim of this study was to evaluate the potential preventive effect of <em>Nigella sativa</em> (black cumin) oil in acoustic trauma. Our experimental study was conducted with 20 Sprague Downey female rats (mean age, 12 months; mean weight 250 g). All of the procedures were held under general anesthesia. Following otoscopic examinations, baseline-hearing thresholds were obtained using auditory brainstem responses (ABR). To create acoustic trauma, the rats were then exposed to white band noise of 4 kHz with an intensity level of 107 dB in a soundproof testing room. On Day 1 following acoustic trauma, hearing threshold measurements were repeated. The rats were divided into two groups as the study group (n: 10) and the controls (n: 10). 2 mL/kg/day of <em>Nigella sativa</em> oil was given to the rats in the study group orally. On Day 4 following acoustic trauma, ABR measurements were repeated again. There was no difference between the baseline hearing thresholds of the rats before acoustic trauma (P&gt;0.005). After the acoustic trauma, hearing thresholds were increased and there was no significant statistically difference between the hearing thresholds of the study and control groups (P=0.979). At the 4<sup>th</sup> day following acoustic trauma, hearing thresholds of the rats in control group were found to be higher than those in the study group (P=0.03). Our results suggest that <em>Nigella sativa</em> oil has a protective effect against acoustic trauma in early period. This finding should be supported with additional experimental and clinical studies, especially to determine the optimal dose, duration and frequency of potential <em>Nigella sativa</em> oil therapy.

The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs

2016 ◽  
Vol 32 (12) ◽  
pp. 1971-1977 ◽  
Author(s):  
Zahra Gholamnezhad ◽  
Mohammad Hossein Boskabady ◽  
Sediqa Amery ◽  
Nassim Vahedi ◽  
Abass Tabatabaei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Pulmonary Complications ◽  
Control Group ◽  
Lung Pathology ◽  
Pathological Changes ◽  
Bronchial Stenosis ◽  
Pathological Evaluation

Pulmonary complications of exposure to sulfur mustard (SM) gas range from no effect or mild symptoms to severe bronchial stenosis. In the present study, the protective effect of vitamin E on the lung inflammation of SM-exposed guinea pigs was examined. Guinea pigs ( n = 5 for each group) were exposed to ethanol (control group), 40 mg/m3 inhaled SM (SME group), SME treated with vitamin E (SME + E), SME treated with dexamethasone (SME + D), and SME treated with both treatments (SME + E + D). Pathological evaluation of the lung was done 14 days postexposure. The epithelial desquamation of trachea and other pathologic changes in the lung of the SME group were significantly higher than those in the control group. Furthermore, the pathological changes of trachea and lung in the SME + E and SME + E + D groups were significantly improved compared with those of SME group. In addition, the pathological changes of trachea and lung of SME + E and SME + E + D animals were significantly less than those of SME + D group.

Protective Effect of Nigella sativa Seeds Against Lead-induced Hepatorenal Damage in Male Rats

2007 ◽  
Vol 10 (17) ◽  
pp. 2809-2816 ◽  
Author(s):  
Abdel-Razik H. Farrag ◽  
Karam A. Mahdy ◽  
Gamal H. Abdel Rahman ◽  
Mostafa M. Osfor
Keyword(s):  
Protective Effect ◽  
Nigella Sativa ◽  
Male Rats
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