scholarly journals Role of Hypolipidemic Drug Clofibrate in Altering Iron Regulatory Proteins IRP1 and IRP2 Activities and Hepatic Iron Metabolism in Rats Fed a Low-Iron Diet

2002 ◽  
Vol 180 (2) ◽  
pp. 118-128 ◽  
Author(s):  
Hui-Ling Huang ◽  
Ning-Sing Shaw
Keyword(s):  
Iron Metabolism ◽  
Regulatory Proteins ◽  
Hepatic Iron ◽  
Iron Regulatory Proteins ◽  
Hypolipidemic Drug ◽  
Irp1 And Irp2

scholarly journals Renal Iron Metabolism: Transferrin Iron Delivery and the Role of Iron Regulatory Proteins

2007 ◽  
Vol 18 (2) ◽  
pp. 401-406 ◽  
Author(s):  
Deliang Zhang ◽  
Esther Meyron-Holtz ◽  
Tracey A. Rouault
Keyword(s):  
Iron Metabolism ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Iron Delivery

scholarly journals The role of iron regulatory proteins in the control of iron metabolism in mammals

2011 ◽  
Vol 1 ◽  
pp. 66-75 ◽  
Author(s):  
Agnieszka Styś ◽  
Rafał R. Starzyński ◽  
Paweł Lipiński
Keyword(s):  
Iron Metabolism ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins

Blood ◽  
2011 ◽  
Vol 118 (22) ◽  
pp. e168-e179 ◽  
Author(s):  
Mayka Sanchez ◽  
Bruno Galy ◽  
Bjoern Schwanhaeusser ◽  
Jonathon Blake ◽  
Tomi Bähr-Ivacevic ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Rna Binding ◽  
Isotope Labeling ◽  
Rna Binding Proteins ◽  
Regulatory Protein ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Ribonucleoprotein Complexes ◽  
Cellular Iron ◽  
Irp1 And Irp2

Abstract Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known IRP-binding mRNAs encode proteins involved in iron uptake, storage, and release as well as heme synthesis. To systematically define the IRE/IRP regulatory network on a transcriptome-wide scale, IRP1/IRE and IRP2/IRE messenger ribonucleoprotein complexes were immunoselected, and the mRNA composition was determined using microarrays. We identify 35 novel mRNAs that bind both IRP1 and IRP2, and we also report for the first time cellular mRNAs with exclusive specificity for IRP1 or IRP2. To further explore cellular iron metabolism at a system-wide level, we undertook proteomic analysis by pulsed stable isotope labeling by amino acids in cell culture in an iron-modulated mouse hepatic cell line and in bone marrow-derived macrophages from IRP1- and IRP2-deficient mice. This work investigates cellular iron metabolism in unprecedented depth and defines a wide network of mRNAs and proteins with iron-dependent regulation, IRP-dependent regulation, or both.

Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the Rat Hippocampus After Heat Stroke

Shock ◽  
2019 ◽  
Vol 51 (6) ◽  
pp. 780-786 ◽  
Author(s):  
Jing Liu ◽  
Mingsheng Wan ◽  
Yun Zhang ◽  
Shu Zhang ◽  
Hongying Zhang ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Heat Stroke ◽  
Rat Hippocampus ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins

Iron Regulatory Proteins in Systemic Iron Metabolism and Erythropoiesis

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. SCI-22-SCI-22
Author(s):  
Matthias W. Hentze
Keyword(s):  
Iron Metabolism ◽  
Iron Homeostasis ◽  
Mutant Mouse ◽  
Conflicts Of Interest ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Cellular Iron ◽  
Regulatory Systems ◽  
Biology I ◽  
Mouse Lines

Abstract Abstract SCI-22 Imbalances of iron homeostasis account for some of the most common human diseases. Pathologies can result from both iron deficiency or overload. The hepcidin/ferroportin and the IRE/IRP regulatory systems balance systemic and cellular iron metabolism, respectively, and understanding their points of intersection and crosstalk represents a major challenge in iron biology. I will discuss an emerging picture from studies with different mutant mouse lines according to which the “cellular” IRE/IRP system determines “set points” via its targets (including ferroportin and HIF2α). These are then subject to modulation via hepcidin in response to systemic cues. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice

2007 ◽  
Vol 422 (3) ◽  
pp. 158-163 ◽  
Author(s):  
Boe-Hyun Kim ◽  
Yong-Chul Jun ◽  
Jae-Kwang Jin ◽  
Jae-Il Kim ◽  
Nam-Ho Kim ◽  
...  
Keyword(s):  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Irp1 And Irp2

scholarly journals Iron-regulatory proteins: molecular biology and pathophysiological implications

2007 ◽  
Vol 9 (33) ◽  
pp. 1-13 ◽  
Author(s):  
Gaetano Cairo ◽  
Stefania Recalcati
Keyword(s):  
Cell Growth ◽  
Molecular Biology ◽  
Iron Metabolism ◽  
Iron Homeostasis ◽  
Regulatory Proteins ◽  
Cellular Functions ◽  
Major Health ◽  
Iron Regulatory Proteins ◽  
Human Disorders ◽  
Apoptosis And Inflammation

AbstractIron is required for key cellular functions, and there is a strong link between iron metabolism and important metabolic processes, such as cell growth, apoptosis and inflammation. Diseases that are directly or indirectly related to iron metabolism represent major health problems. Iron-regulatory proteins (IRPs) 1 and 2 are key controllers of vertebrate iron metabolism and post-transcriptionally regulate expression of the major iron homeostasis genes. Here we discuss how dysregulation of the IRP system can result from both iron-related and unrelated effectors and explain how this can have important pathological consequences in several human disorders.

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