The Use of Mass Spectrometry in Studying Protein-Protein Interaction

2006 ◽  
pp. 33-48 ◽  
Author(s):  
Yi Wang ◽  
Parvin Yazdi ◽  
Jun Qin
Keyword(s):  
Mass Spectrometry ◽  
Protein Interaction ◽  
Protein Protein Interaction

The Role of Protein Dynamics in Increasing Binding Affinity for an Engineered Protein−Protein Interaction Established by H/D Exchange Mass Spectrometry†

Biochemistry ◽  
2006 ◽  
Vol 45 (28) ◽  
pp. 8488-8498 ◽  
Author(s):  
James R. Horn ◽  
Brian Kraybill ◽  
Elizabeth J. Petro ◽  
Stephen J. Coales ◽  
Jeffrey A. Morrow ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Protein Dynamics ◽  
Binding Affinity ◽  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Exchange Mass Spectrometry

A native mass spectrometry platform identifies HOP inhibitors that modulate the HSP90–HOP protein–protein interaction

2021 ◽  
Author(s):  
Clinton G. L. Veale ◽  
Maria Mateos-Jiménez ◽  
Michaelone C. Vaaltyn ◽  
Ronel Müller ◽  
Matodzi P. Makhubu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Protein Interaction ◽  
Protein Interactions ◽  
Native Mass Spectrometry ◽  
Protein Protein Interactions ◽  
Protein Protein Interaction

We demonstrate the potential of native mass spectrometry for modelling Protein–Protein Interactions, leading to the identification of inhibitors of the HSP90–HOP PPI.

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