B Lymphocyte Depletion Therapy in Autoimmune Disorders: Chasing Trojan Horses

2006 ◽  
pp. 291-311 ◽  
Author(s):  
Jonathan C. W. Edwards ◽  
Geraldine Cambridge ◽  
Maria J. Leandro
Keyword(s):  
B Lymphocyte ◽  
Autoimmune Disorders ◽  
Lymphocyte Depletion

B-lymphocyte depletion therapy in rheumatoid arthritis and other autoimmune disorders

2002 ◽  
Vol 30 (4) ◽  
pp. 824-828 ◽  
Author(s):  
J. C. W. Edwards ◽  
M.J. Leandro ◽  
G. Cambridge
Keyword(s):  
Rheumatoid Arthritis ◽  
B Lymphocyte ◽  
Lymphocyte Subsets ◽  
Autoimmune Disorders ◽  
Lymphocyte Depletion ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
Early Evidence ◽  
Wide Range ◽  
Rate Limiting

B-lymphocyte depletion therapy is being explored in a wide range of autoimmune disorders. In many, there is early evidence for efficacy, and immunosuppression has not been a major problem. The mechanism of action is unclear, but appears to be consistent with the lowering of autoantibody levels, where relevant antibodies are quantifiable. An interesting finding is the persistence of clinical improvement for periods of 1 year or more after B-lymphocyte return, which supports the concept that stochastic generation of rare pathogenic B-lymphocyte subsets may be a rate-limiting step in pathogenesis.

scholarly journals Evidence of Intrathyroidal B-Lymphocyte Depletion after rituximab Therapy in a Patient with Graves’ Disease

2007 ◽  
Vol 92 (10) ◽  
pp. 3762-3763 ◽  
Author(s):  
Daniel El Fassi ◽  
Ole Clemmensen ◽  
Claus H. Nielsen ◽  
Rona Z. Silkiss ◽  
Laszlo Hegedüs
Keyword(s):  
B Lymphocyte ◽  
Graves Disease ◽  
Lymphocyte Depletion

scholarly journals Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

2009 ◽  
Vol 361 (22) ◽  
pp. 2143-2152 ◽  
Author(s):  
Mark D. Pescovitz ◽  
Carla J. Greenbaum ◽  
Heidi Krause-Steinrauf ◽  
Dorothy J. Becker ◽  
Stephen E. Gitelman ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
B Lymphocyte ◽  
Cell Function ◽  
Lymphocyte Depletion

αβ T and B lymphocyte depletion by the prodigy clinimacs. Results of seven graft processing procedures from haploidentical donors

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S76-S77
Author(s):  
E. Haastrup ◽  
M. Ifversen ◽  
C. Heilmann ◽  
A. Fischer-Nielsen
Keyword(s):  
B Lymphocyte ◽  
Lymphocyte Depletion

scholarly journals B Lymphocyte Depletion with the Monoclonal Antibody Rituximab in Graves’ Disease: A Controlled Pilot Study

2007 ◽  
Vol 92 (5) ◽  
pp. 1769-1772 ◽  
Author(s):  
Daniel El Fassi ◽  
Claus H. Nielsen ◽  
Steen J. Bonnema ◽  
Hans C. Hasselbalch ◽  
Laszlo Hegedüs
Keyword(s):  
Monoclonal Antibody ◽  
Pilot Study ◽  
B Lymphocyte ◽  
Graves Disease ◽  
Lymphocyte Depletion
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