Long-term B-lymphocyte depletion and remission of granulomatosis with polyangiitis after two courses of rituximab treatment

Rheumatology ◽  
2020 ◽  
Author(s):  
Larissa Valor-Méndez ◽  
Arnd Kleyer ◽  
Jürgen Rech ◽  
Bernhard Manger ◽  
Georg  Schett
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
B Lymphocyte ◽  
Lymphocyte Depletion

scholarly journals Long-term B-Lymphocyte Depletion With Rituximab in Patients With Relapsing-Remitting Multiple Sclerosis

2009 ◽  
Vol 66 (2) ◽  
Author(s):  
Olaf Stüve ◽  
Verena I. Leussink ◽  
Ruth Fröhlich ◽  
Bernhard Hemmer ◽  
Hans-Peter Hartung ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
B Lymphocyte ◽  
Lymphocyte Depletion ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

LONG-TERM CADAVER ALLOGRAFT SURVIVAL IN THE RECIPIENT WITH A POSITIVE B LYMPHOCYTE CROSSMATCH

1979 ◽  
Vol 27 (5) ◽  
pp. 315-318 ◽  
Author(s):  
Robert B. Ettenger ◽  
Christel H. Uittenbogaart ◽  
Alfred J. Pennisi ◽  
Mohammad H. Malekzadeh ◽  
Richard N. Fine
Keyword(s):  
B Lymphocyte ◽  
Allograft Survival

scholarly journals Evidence of Intrathyroidal B-Lymphocyte Depletion after rituximab Therapy in a Patient with Graves’ Disease

2007 ◽  
Vol 92 (10) ◽  
pp. 3762-3763 ◽  
Author(s):  
Daniel El Fassi ◽  
Ole Clemmensen ◽  
Claus H. Nielsen ◽  
Rona Z. Silkiss ◽  
Laszlo Hegedüs
Keyword(s):  
B Lymphocyte ◽  
Graves Disease ◽  
Lymphocyte Depletion

scholarly journals Long-Term Outcomes Among Participants in the WEGENT Trial of Remission-Maintenance Therapy for Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis

2016 ◽  
Vol 68 (3) ◽  
pp. 690-701 ◽  
Author(s):  
Xavier Puéchal ◽  
Christian Pagnoux ◽  
Élodie Perrodeau ◽  
Mohamed Hamidou ◽  
Jean-Jacques Boffa ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Granulomatosis With Polyangiitis ◽  
Microscopic Polyangiitis ◽  
Long Term Outcomes ◽  
Remission Maintenance

scholarly journals Granulomatosis with Polyangiitis: Recurrence or Treatment Consequences?

2021 ◽  
Author(s):  
Andreia Diegues ◽  
Joana Tavares ◽  
Diogo Sá ◽  
João Oliveira ◽  
Diana Fernandes ◽  
...  
Keyword(s):  
Intracranial Hypertension ◽  
Clinical Improvement ◽  
Granulomatosis With Polyangiitis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Lung Nodules ◽  
Rare Form ◽  
Anca Associated Vasculitis

Granulomatosis with polyangiitis (GPA) is the most common antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We describe the case of a 38-year-old woman with relapsing GPA who presented with intracranial hypertension, followed by the appearance of cavitated lung nodules despite treatment with azathioprine. Clinical improvement and ANCA titre reduction were observed after rituximab treatment. We report a rare form of GPA relapse and highlight the challenge of following-up patients with GPA, in whom can be hard to distinguish relapse from the consequences of long-term immunosuppression.

Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 863-868 ◽  
Author(s):  
Sophia Khaldoyanidi ◽  
Lyudmila Sikora ◽  
David H. Broide ◽  
Marc E. Rothenberg ◽  
P. Sriramarao
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
Bone Marrow Cells ◽  
Extramedullary Hematopoiesis ◽  
Interleukin 5 ◽  
Bone Marrow Cultures ◽  
Constitutive Overexpression ◽  
Hematopoietic Activity

Abstract The differentiation of eosinophils from hematopoietic precursors and their subsequent maturation, chemotaxis, and activation is primarily regulated by interleukin-5 (IL-5). To examine the effect of chronic IL-5 exposure on hematopoiesis, IL-5 transgenic (IL-5trg) mice and wild-type BALB/c (WT) mice were examined. In comparison to WT mice, a significant alteration in bone marrow hematopoiesis was observed in IL-5trg mice. Although the total number of myeloid progenitors in the bone marrow of IL-5trg mice was not significantly altered, the number of long-term culture-initiating cells (LTC-ICs) was 1.5-fold lower than that observed in WT mice. Furthermore, IL-5trg mice failed to demonstrate hematopoietic activity in long-term bone marrow cultures, which correlated with a significant decrease in the number of bone marrow mesenchymal/stromal progenitor (MSP) cells in these mice. In comparison to WT mice, a 10-fold decrease was observed in the number of fibroblast colony-forming units (CFU-Fs) in IL-5trg bone marrow. Hematopoietic activity of IL-5trg bone marrow cells was rescued by cultivation on preestablished layers of bone marrow-derived stromal cells. However, in contrast to bone marrow, increased hematopoietic activity was observed in the spleen and peripheral blood of IL-5trg mice. Likewise, the numbers of LTC-ICs and granulocyte-macrophage, macrophage, eosinophil, B-lymphocyte progenitors in the peripheral blood and spleen of IL-5trg mice were approximately 20-fold higher than in WT mice. A significant increase in CFU-F numbers was also observed in the spleens of IL-5trg mice compared with WT mice. Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites.

scholarly journals 129. RESPIRATORY INVOLVEMENT IN PATIENTS WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS: CLINICAL AND SEROLOGICAL PREDICTORS OF LONG-TERM ASTHMA SEVERITY

Rheumatology ◽  
2019 ◽  
Vol 58 (Supplement_2) ◽  
Author(s):  
Alvise Berti ◽  
Divi Cornec ◽  
Marta Casal Moura ◽  
Robert Smith ◽  
Lorenzo Dagna ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Asthma Severity ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Respiratory Involvement ◽  
Eosinophilic Granulomatosis
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