Urethral Carcinoma

Primary tumor surgery improves survival in non-metastatic primary urethral carcinoma patients: a large population-based investigation

BMC Cancer ◽

10.1186/s12885-021-08603-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jie Wu ◽

Yu-Chen Wang ◽

Wen-Jie Luo ◽

Bo-Dai ◽

Ding-Wei Ye ◽

...

Keyword(s):

Regression Model ◽

Competing Risks ◽

Primary Tumor ◽

Cox Regression ◽

Radical Surgery ◽

Large Population ◽

Local Therapy ◽

Primary Site ◽

Urethral Carcinoma ◽

The Impact

Abstract Background Primary urethral carcinoma (PUC) is a rare genitourinary malignancy with a relatively poor prognosis. The aim of this study was to examine the impact of surgery on survival of patients diagnosed with PUC. Methods A total of 1544 PUC patients diagnosed between 2004 and 2016 were identified based on the SEER database. The Kaplan-Meier estimate and the Fine and Gray competing risks analysis were performed to assess overall survival (OS) and cancer-specific mortality (CSM). The multivariate Cox regression model and competing risks regression model were used to identify independent risk factors of OS and cancer-specific survival (CSS). Results The 5-yr OS was significantly better in patients who received either local therapy (39.8%) or radical surgery (44.7%) compared to patients receiving no surgery of the primary site (21.5%) (p < 0.001). Both local therapy and radical surgery were each independently associated with decreased CSM, with predicted 5-yr cumulative incidence of 45.4 and 43.3%, respectively, compared to 64.7% for patients receiving no surgery of the primary site (p < 0.001). Multivariate analyses demonstrated that primary site surgery was independently associated with better OS (local therapy, p = 0.037; radical surgery, p < 0.001) and decreased CSM (p = 0.003). Similar results were noted regardless of age, sex, T stage, N stage, and AJCC prognostic groups based on subgroup analysis. However, patients with M1 disease who underwent primary site surgery did not exhibit any survival benefit. Conclusion Surgery for the primary tumor conferred a survival advantage in non-metastatic PUC patients.

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Female primary urethral carcinoma: A rare case report

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2021.106100 ◽

2021 ◽

pp. 106100

Author(s):

Mochammad Ecky Pratama ◽

Jufriady Ismy ◽

Reno Kamarlis ◽

Muhammad Puteh Mauny

Keyword(s):

Case Report ◽

Rare Case ◽

Urethral Carcinoma ◽

Rare Case Report

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Urethral carcinoma in situ: recognition and management

International Urology and Nephrology ◽

10.1007/s11255-017-1512-3 ◽

2017 ◽

Vol 49 (4) ◽

pp. 637-641 ◽

Cited By ~ 2

Author(s):

Ricardo H. Berjeaut ◽

Maliza D. I. Persaud ◽

Nikolai Sopko ◽

Arthur L. Burnett

Keyword(s):

Carcinoma In Situ ◽

Urethral Carcinoma

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Histopathology Reporting ◽

10.1007/978-1-4471-3671-2_32 ◽

2000 ◽

pp. 301-305

Author(s):

Derek C. Allen

Keyword(s):

Urethral Carcinoma

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Impact of perioperative chemotherapy on survival in patients with advanced primary urethral cancer: Results of the international collaboration on primary urethral carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.4587 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 4587-4587

Author(s):

Georgios Gakis ◽

Todd Matthew Morgan ◽

Siamak Daneshmand ◽

Kirk A. Keegan ◽

Harras B Zaid ◽

...

Keyword(s):

International Collaboration ◽

Perioperative Chemotherapy ◽

Urethral Carcinoma

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Undiagnosed urethral carcinoma: an unusual cause of female urinary retention

Urology ◽

10.1016/s0090-4295(99)00446-x ◽

2000 ◽

Vol 55 (3) ◽

pp. 436 ◽

Cited By ~ 3

Author(s):

K.C Kobashi ◽

T.H Hong ◽

G.E Leach

Keyword(s):

Urinary Retention ◽

Urethral Carcinoma

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The clinicopathological and survival analysis of urological mucosal melanoma: A single-center retrospective observational study.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e21588 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e21588-e21588

Author(s):

Bixia Tang ◽

Xieqiao Yan ◽

Zhihong Chi ◽

Siming Li ◽

Chuanliang Cui ◽

...

Keyword(s):

Urinary Tract ◽

Regional Lymph Node ◽

Stage Iv ◽

Staging System ◽

Tnm Staging ◽

Mucosal Melanoma ◽

Future Research ◽

Molecular Characteristics ◽

Urethral Carcinoma ◽

Tnm Staging System

e21588 Background: Primary mucosal melanoma arising in the urinary tract is rare and poorly characterized. Methods: The records of patients with urological mucosal melanoma who presented to the department of Renal Cancer and Melanoma of Peking University Cancer Hospital between September, 2004 and April, 2019 were reviewed. Available clinicopathological and molecular characteristics were summarized, including pathological parameters, gene mutation, primary surgical intervention, systemic treatment and clinical course. The rates of local recurrence rate, loco-regional lymph node metastasis and distant metastasis were assessed. American Joint Committee on Cancer (AJCC) TNM Staging System for bladder cancer/renal pelvis and ureter cancer/urethral carcinoma (8th ed., 2017) were adopted for staging. Results: Fifty-eight patients were involved in the study with a median age of 62.5 years (range: 32-82). The anatomic sites of the primary urological mucosal melanomas were from the urethra (89.7%), bladder (6.9%), ureter (0%) and kidney (0%), and the left (4.4%) were from multiple loci. At initial diagnosis, 75.9% (n=44) were stage I/II disease, 1.7% (n=1) stage III, and 22.4% (n=13) stage IV. There was 3.4% incidence of CKIT mutation and 1.7% of BRAF mutation. After median follow-up of 22.6 mo, 31.4% (16/51) relapsed locally after organ-preserved surgery. 21.6% (11/51) and 39.2% (20/51) developed metastases to reginal lymph nodes and distance, respectively. The median relapse free survival and median overall survival were 12.2 (95%CI: 7.9-16.4) mo and 33.9 (95%CI: 19.2-48.6) mo, respectively. Univariate Cox analysis showed that TNM stage and systemic adjuvant therapy were the prognostic factors of OS, while no association was found with Breslow thickness, miotic rate, ulceration and gender. Conclusions: Urological mucosal melanoma predominantly arises from lower urinary tract with rare BRAF and CKIT mutation. AJCC TNM Staging System for urothelial carcinoma is proved practical for urothelial melanoma, which should be validated in larger population. Future research is required to identify adjuvant treatment approaches to improve disease outcomes.

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