Nuclear Receptor Coregulators in Metabolism and Disease

2015 ◽  
pp. 95-135 ◽  
Author(s):  
Marco Giudici ◽  
Saioa Goni ◽  
Rongrong Fan ◽  
Eckardt Treuter
Keyword(s):  
Nuclear Receptor ◽  
Nuclear Receptor Coregulators

scholarly journals Nuclear Receptor Coregulators: Judges, Juries, and Executioners of Cellular Regulation

2007 ◽  
Vol 27 (5) ◽  
pp. 691-700 ◽  
Author(s):  
David M. Lonard ◽  
Bert W. O'Malley
Keyword(s):  
Nuclear Receptor ◽  
Cellular Regulation ◽  
Nuclear Receptor Coregulators

Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation

2011 ◽  
Vol 36 (5) ◽  
pp. 272-281 ◽  
Author(s):  
Shigeaki Kato ◽  
Atsushi Yokoyama ◽  
Ryoji Fujiki
Keyword(s):  
Nuclear Receptor ◽  
Epigenetic Regulation ◽  
Nuclear Receptor Coregulators

scholarly journals Nuclear receptor coregulators: modulators of pathology and therapeutic targets

2012 ◽  
Vol 8 (10) ◽  
pp. 598-604 ◽  
Author(s):  
David M. Lonard ◽  
Bert W. O'Malley
Keyword(s):  
Nuclear Receptor ◽  
Therapeutic Targets ◽  
Nuclear Receptor Coregulators

scholarly journals A New Family of Nuclear Receptor Coregulators That Integrate Nuclear Receptor Signaling through CREB-Binding Protein

2000 ◽  
Vol 20 (14) ◽  
pp. 5048-5063 ◽  
Author(s):  
Muktar A. Mahajan ◽  
Herbert H. Samuels
Keyword(s):  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Binding Protein ◽  
Nuclear Hormone Receptors ◽  
Dependent Manner ◽  
Creb Binding Protein ◽  
Activation Domain ◽  
High Affinity ◽  
New Family ◽  
Nuclear Receptor Coregulators

ABSTRACT We describe the cloning and characterization of a new family of nuclear receptor coregulators (NRCs) which modulate the function of nuclear hormone receptors in a ligand-dependent manner. NRCs are expressed as alternatively spliced isoforms which may exhibit different intrinsic activities and receptor specificities. The NRCs are organized into several modular structures and contain a single functional LXXLL motif which associates with members of the steroid hormone and thyroid hormone/retinoid receptor subfamilies with high affinity. Human NRC (hNRC) harbors a potent N-terminal activation domain (AD1), which is as active as the herpesvirus VP16 activation domain, and a second activation domain (AD2) which overlaps with the receptor-interacting LXXLL region. The C-terminal region of hNRC appears to function as an inhibitory domain which influences the overall transcriptional activity of the protein. Our results suggest that NRC binds to liganded receptors as a dimer and this association leads to a structural change in NRC resulting in activation. hNRC binds CREB-binding protein (CBP) with high affinity in vivo, suggesting that hNRC may be an important functional component of a CBP complex involved in mediating the transcriptional effects of nuclear hormone receptors.

scholarly journals Differential expression of nuclear receptor coregulators in mouse tissues

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Songtao Yu ◽  
Joy Sarkar ◽  
Janardan K Reddy
Keyword(s):  
Differential Expression ◽  
Nuclear Receptor ◽  
Mouse Tissues ◽  
Nuclear Receptor Coregulators

Role of Nuclear Receptor Coregulators in Hormone Resistant Breast Cancer

2000 ◽  
Author(s):  
Justine D. Graham ◽  
Kathryn B. Horwitz
Keyword(s):  
Breast Cancer ◽  
Nuclear Receptor ◽  
Nuclear Receptor Coregulators

Nuclear Receptor Coregulators in Human Diseases

2008 ◽  
pp. 1-133
Author(s):  
Rainer B. Lanz ◽  
David M. Lonard ◽  
Bert W. O'Malley
Keyword(s):  
Nuclear Receptor ◽  
Human Diseases ◽  
Nuclear Receptor Coregulators

Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α

2013 ◽  
Vol 138 ◽  
pp. 421-426 ◽  
Author(s):  
Mei Ji ◽  
Yuhuan Liu ◽  
Shengsheng Yang ◽  
Dongxia Zhai ◽  
Danying Zhang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Nuclear Receptor ◽  
Stromal Cells ◽  
Estrogen Receptor Α ◽  
Nuclear Receptor Coregulators
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