T-Cell Receptor Transgenic Models of Inflammatory Disorders: Relevance for Atopic Dermatitis?

2006 ◽  
pp. 175-191
Author(s):  
U. Niesner ◽  
F. Hardung ◽  
A. Scheffold ◽  
A. Radbruch
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Transgenic Models ◽  
Inflammatory Disorders

An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis

2001 ◽  
Vol 107 (2) ◽  
pp. 359-366 ◽  
Author(s):  
Amy L. Woodward ◽  
Jonathan M. Spergel ◽  
Harri Alenius ◽  
Emiko Mizoguchi ◽  
Atul K. Bhan ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
T Cell ◽  
B Cells ◽  
Mouse Model ◽  
T Cell Receptor ◽  
Γδ T Cells ◽  
Cell Receptor ◽  
Αβ T Cells

001 T cell receptor vβ expression of atopic dermatitis

1995 ◽  
Vol 10 (1) ◽  
pp. 63
Author(s):  
H. Yamada ◽  
T. Yudate ◽  
M. Matukura ◽  
T. Tezuka
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Receptor Vβ

scholarly journals Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells

2019 ◽  
Vol 88 (2) ◽  
Author(s):  
Fatkhanuddin Aziz ◽  
Junzo Hisatsune ◽  
Liansheng Yu ◽  
Junko Kajimura ◽  
Yusuke Sato’o ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
T Cells ◽  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Receptor ◽  
T Cell Activation ◽  
Cell Receptor ◽  
Broth Culture ◽  
Content Type ◽  
Link Type

ABSTRACT While investigating the virulence traits of Staphylococcus aureus adhering to the skin of atopic-dermatitis (AD) patients, we identified a novel open reading frame (ORF) with structural similarity to a superantigen from genome sequence data of an isolate from AD skin. Concurrently, the same ORF was identified in a bovine isolate of S. aureus and designated SElY (H. K. Ono, Y. Sato’o, K. Narita, I. Naito, et al., Appl Environ Microbiol 81:7034–7040, 2015, https://doi.org/10.1128/AEM.01873-15). Recombinant SElYbov had superantigen activity in human peripheral blood mononuclear cells. It further demonstrated emetic activity in a primate animal model, and it was proposed that SElY be renamed SEY (H. K. Ono, S. Hirose, K. Narita, M. Sugiyama, et al., PLoS Pathog 15:e1007803, 2019, https://doi.org/10.1371/journal.ppat.1007803). Here, we investigated the prevalence of the sey gene in 270 human clinical isolates of various origins in Japan. Forty-two strains were positive for the sey gene, and the positive isolates were from patients with the skin diseases atopic dermatitis and impetigo/staphylococcal scalded skin syndrome (SSSS), with a detection rate of ∼17 to 22%. There were three variants of SEY (SEY1, SEY2, and SEY3), and isolates producing SEY variants formed three distinct clusters corresponding to clonal complexes (CCs) 121, 59, and 20, respectively. Most sey+ isolates produced SEY in broth culture. Unlike SEYbov, the three recombinant SEY variants exhibited stability against heat treatment. SEY predominantly activated human T cells with a particular T-cell receptor (TCR) Vα profile, a unique observation since most staphylococcal enterotoxins exert their superantigenic activities through activating T cells with specific TCR Vβ profiles. SEY may act to induce localized inflammation via skin-resident T-cell activation, facilitating the pathogenesis of S. aureus infection in disrupted epithelial barriers.

Association between T cell receptor variable segments, skin homing T cells and staphylococcal infection in atopic dermatitis

1997 ◽  
Vol 56 ◽  
pp. 436
Author(s):  
M.J. Torres ◽  
F.J. Gonzalez ◽  
J.L. Corzo ◽  
M.D. Giron ◽  
M.J. Carvajal ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Staphylococcal Infection ◽  
Skin Homing

scholarly journals Expression of T Cell Receptor Vβ Chain in Lesional Skin of Atopic Dermatitis

1998 ◽  
Vol 78 (6) ◽  
pp. 424-427 ◽  
Author(s):  
Seog-Jun Ha, Hyun-Jeong Lee, Dae-Gyoo Byun,
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Lesional Skin ◽  
T Cell Receptor Vβ

Peripheral Blood T-Cell Receptor ?-Chain V-Repertoire in Atopic Dermatitis Patients After In Vitro Exposure to Pityrosporum orbiculare Extract

1999 ◽  
Vol 49 (3) ◽  
pp. 293-301 ◽  
Author(s):  
C. JOHANSSON ◽  
M. JEDDI-TEHRANI ◽  
J. GRUNEWALD ◽  
M. TENGVALL LINDER ◽  
Å. BENGTSSON ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Receptor ◽  
Peripheral Blood ◽  
Cell Receptor ◽  
In Vitro Exposure ◽  
Receptor Chain ◽  
Pityrosporum Orbiculare
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