The Genetic Regulation of Pigment Cell Development

2007 ◽  
pp. 155-169 ◽  
Author(s):  
Debra L. Silver ◽  
Ling Hou ◽  
William J. Pavan
Keyword(s):  
Pigment Cell ◽  
Genetic Regulation ◽  
Cell Development

scholarly journals Regulation of melanocyte development by ligand-dependent BMP signaling underlies oncogenic BMP signaling in melanoma

2019 ◽  
Author(s):  
Alec K. Gramann ◽  
Arvind M. Venkatesan ◽  
Melissa Guerin ◽  
Craig J. Ceol
Keyword(s):  
Neural Crest ◽  
Pigment Cell ◽  
Terminal Differentiation ◽  
Melanoma Cells ◽  
Cell Development ◽  
Bmp Signaling ◽  
Pigment Cells ◽  
Cell Type ◽  
Neural Crest Development ◽  
Direct Regulation

AbstractPreventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses differentiation of melanoma cells. Previous studies have identified roles for GDF6 orthologs during early embryonic and neural crest development, but have not identified direct regulation of melanocyte development by GDF6. Here, we investigate the BMP ligand gdf6a, a zebrafish ortholog of human GDF6, during the development of melanocytes from the neural crest. We establish that the loss of gdf6a or inhibition of BMP signaling during neural crest development disrupts normal pigment cell development, leading to an increase in the number of melanocytes and a corresponding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish. This shift occurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF, a key regulator of melanocyte development that is also targeted by oncogenic BMP signaling. Together, these results indicate that the oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.

Pigment Cell Development in Teleosts

2021 ◽  
pp. 209-246
Author(s):  
Hisashi Hashimoto ◽  
Makoto Goda ◽  
Robert N. Kelsh
Keyword(s):  
Pigment Cell ◽  
Cell Development

scholarly journals Molecular and genetic regulation of pig pancreatic islet cell development

Development ◽  
2020 ◽  
Vol 147 (6) ◽  
pp. dev186213 ◽  
Author(s):  
Seokho Kim ◽  
Robert L. Whitener ◽  
Heshan Peiris ◽  
Xueying Gu ◽  
Charles A. Chang ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Genetic Regulation ◽  
Cell Development ◽  
Pancreatic Islet Cell

scholarly journals Sox5 Functions as a Fate Switch in Medaka Pigment Cell Development

PLoS Genetics ◽  
2014 ◽  
Vol 10 (4) ◽  
pp. e1004246 ◽  
Author(s):  
Yusuke Nagao ◽  
Takao Suzuki ◽  
Atsushi Shimizu ◽  
Tetsuaki Kimura ◽  
Ryoko Seki ◽  
...  
Keyword(s):  
Pigment Cell ◽  
Cell Development

scholarly journals An analysis of pigment cell development in the periodic albino mutant of Xenopus

Development ◽  
1979 ◽  
Vol 52 (1) ◽  
pp. 165-170
Author(s):  
Gillian J. MacMillan
Keyword(s):  
Cell Differentiation ◽  
Neural Crest ◽  
Pigment Cell ◽  
Cell Development ◽  
Pigment Cells ◽  
Wild Type ◽  
Mutant Effect ◽  
Albino Mutant ◽  
Cells Cultured ◽  
Periodic Albino

The periodic albino mutant (apap) of Xenopus in which the development of melanophoresis impaired, is further reported here to possess an aberrant pattern of iridophore differentiation. The development of mutant and wild-type neural crest explants isolated in vesicles derived from tissues from identical and different genotypes was examined to determine if the mutant effect resides in the pigment cells or is mediated by the environmental tissues. Mutant melanophores and iridophores cultured in either mutant or wild-type tissues exhibited mutant patterns of differentiation. Wild-type pigment cells cultured in both wild-type and mutant tissues exhibited wild-type patterns of differentiation. Hence the mutation affects the capacities of melanoblasts and iridoblasts to differentiate but not the ability of the environmental tissues to support pigment cell differentiation.

scholarly journals Zebrafish pigment cells develop directly from persistent highly multipotent progenitors.

2021 ◽  
Author(s):  
Masataka Nikaido ◽  
Tatiana Subkhankulova ◽  
Leonid A. Uroshlev ◽  
Artem J. Kasianov ◽  
Karen Camargo Sosa ◽  
...  
Keyword(s):  
Pigment Cell ◽  
Transcriptional Profiling ◽  
Cell Types ◽  
Cell Development ◽  
Lineage Tracing ◽  
Pigment Cells ◽  
Multipotent Stem Cells ◽  
Multipotent Progenitors ◽  
Fate Restriction

Neural crest cells (NCCs) are highly multipotent stem cells. A long-standing controversy exists over the mechanism of NCC fate specification, specifically regarding the presence and potency of intermediate progenitors. The direct fate restriction (DFR) model, based on early in vivo clonal studies, hypothesised that intermediates are absent and that migrating cells maintain full multipotency. However, most authors favour progressive fate restriction (PFR) models, with fully multipotent early NCCs (ENCCs) transitioning to partially-restricted intermediates before committing to individual fates. Here, single cell transcriptional profiling of zebrafish pigment cell development leads to us proposing a Cyclical Fate Restriction mechanism of NCC development that reconciles the DFR and PFR models. Our clustering of single NCC Nanostring transcriptional profiles identifies only broadly multipotent intermediate states between ENCCs and differentiated melanocytes and iridophores. Leukocyte tyrosine kinase (Ltk) marks the multipotent progenitor and iridophores, consistent with biphasic ltk expression. Ltk inhibitor and constitutive activation studies support expression at an early multipotent stage, whilst lineage-tracing of ltk-expressing cells reveals their multipotency extends beyond pigment cell-types to neural fates. We conclude that pigment cell development does not involve a conventional PFR mechanism, but instead occurs directly and more dynamically from a broadly multipotent intermediate state.

scholarly journals Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Alec K Gramann ◽  
Arvind M Venkatesan ◽  
Melissa Guerin ◽  
Craig J Ceol
Keyword(s):  
Neural Crest ◽  
Pigment Cell ◽  
Terminal Differentiation ◽  
Melanoma Cells ◽  
Cell Development ◽  
Bmp Signaling ◽  
Pigment Cells ◽  
Cell Type ◽  
Neural Crest Development ◽  
Direct Regulation

Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses differentiation of melanoma cells. Previous studies have identified roles for GDF6 orthologs during early embryonic and neural crest development, but have not identified direct regulation of melanocyte development by GDF6. Here, we investigate the BMP ligand gdf6a, a zebrafish ortholog of human GDF6, during the development of melanocytes from the neural crest. We establish that the loss of gdf6a or inhibition of BMP signaling during neural crest development disrupts normal pigment cell development, leading to an increase in the number of melanocytes and a corresponding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish. This shift occurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF, a key regulator of melanocyte development that is also targeted by oncogenic BMP signaling. Together, these results indicate that the oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.

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