Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex

2007 ◽  
pp. 91-101
Author(s):  
Eunice Y. Yuen ◽  
Zhen Yan
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Receptor Trafficking ◽  
And Function

Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP)

2006 ◽  
Vol 23 (11) ◽  
pp. 2847-2856 ◽  
Author(s):  
Steven P. Braithwaite ◽  
Michael Adkisson ◽  
John Leung ◽  
Adrian Nava ◽  
Brett Masterson ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Tyrosine Phosphatase ◽  
Receptor Trafficking ◽  
And Function

scholarly journals GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function

2017 ◽  
Vol 62 (6) ◽  
pp. 589-597 ◽  
Author(s):  
Wenjuan Chen ◽  
Christine Shieh ◽  
Sharon A Swanger ◽  
Anel Tankovic ◽  
Margaret Au ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Nmda Receptor ◽  
Receptor Trafficking ◽  
And Function

scholarly journals Expression of the NR2B-NMDA receptor trafficking complex in prefrontal cortex from a group of elderly patients with schizophrenia

2010 ◽  
Vol 119 (1-3) ◽  
pp. 198-209 ◽  
Author(s):  
L.V. Kristiansen ◽  
B. Bakir ◽  
V. Haroutunian ◽  
J.H. Meador-Woodruff
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Elderly Patients ◽  
Receptor Trafficking

scholarly journals Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tiziana Imbriglio ◽  
Remy Verhaeghe ◽  
Nico Antenucci ◽  
Stefania Maccari ◽  
Giuseppe Battaglia ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Metabotropic Glutamate Receptors ◽  
Adult Life ◽  
Developmental Time ◽  
Postnatal Life ◽  
Developmental Studies ◽  
Knock Out ◽  
Nmda Receptor Subunits ◽  
The Impact

AbstractmGlu5 metabotropic glutamate receptors are highly expressed and functional in the early postnatal life, and are known to positively modulate NMDA receptor function. Here, we examined the expression of NMDA receptor subunits and interneuron-related genes in the prefrontal cortex and hippocampus of mGlu5−/− mice and wild-type littermates at three developmental time points (PND9, − 21, and − 75). We were surprised to find that expression of all NMDA receptor subunits was greatly enhanced in mGlu5−/− mice at PND21. In contrast, at PND9, expression of the GluN2B subunit was enhanced, whereas expression of GluN2A and GluN2D subunits was reduced in both regions. These modifications were transient and disappeared in the adult life (PND75). Changes in the transcripts of interneuron-related genes (encoding parvalbumin, somatostatin, vasoactive intestinal peptide, reelin, and the two isoforms of glutamate decarboxylase) were also observed in mGlu5−/− mice across postnatal development. For example, the transcript encoding parvalbumin was up-regulated in the prefrontal cortex of mGlu5−/− mice at PND9 and PND21, whereas it was significantly reduced at PND75. These findings suggest that in mGlu5−/− mice a transient overexpression of NMDA receptor subunits may compensate for the lack of the NMDA receptor partner, mGlu5. Interestingly, in mGlu5−/− mice the behavioral response to the NMDA channel blocker, MK-801, was significantly increased at PND21, and largely reduced at PND75. The impact of adaptive changes in the expression of NMDA receptor subunits should be taken into account when mGlu5−/− mice are used for developmental studies.

scholarly journals Structure and function of the prefrontal cortex

2016 ◽  
Vol 36 (1) ◽  
pp. 1-8
Author(s):  
Masataka Watanabe
Keyword(s):  
Prefrontal Cortex ◽  
Structure And Function ◽  
And Function
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