scholarly journals Effect of ambient extracellular glutamate on Drosophila glutamate receptor trafficking and function

2008 ◽  
Vol 195 (1) ◽  
Author(s):  
Kaiyun Chen ◽  
Hrvoje Augustin ◽  
David E. Featherstone
Keyword(s):  
Glutamate Receptor ◽  
Receptor Trafficking ◽  
Extracellular Glutamate ◽  
Glutamate Receptor Trafficking ◽  
And Function

scholarly journals Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners

2013 ◽  
Vol 41 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Gareth M. Thomas ◽  
Richard L. Huganir
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Receptors ◽  
Glutamate Receptor ◽  
Pdz Domain ◽  
Receptor Trafficking ◽  
Ionotropic Glutamate Receptor ◽  
Novel Treatments ◽  
Neuronal Regulation ◽  
Glutamate Receptor Trafficking ◽  
And Function

In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions. In the present paper, we review recent advances regarding the regulation of ionotropic glutamate receptor trafficking and function by palmitoylation.

scholarly journals Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Kento Ojima ◽  
Kazuki Shiraiwa ◽  
Kyohei Soga ◽  
Tomohiro Doura ◽  
Mikiko Takato ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Glutamate Receptor ◽  
Receptor Trafficking ◽  
Protein Labeling ◽  
Selective Labeling ◽  
Receptor Localization ◽  
Glutamate Receptor Trafficking ◽  
Versatile Tool ◽  
The Central Nervous System ◽  
Long Lifetime

AbstractThe regulation of glutamate receptor localization is critical for development and synaptic plasticity in the central nervous system. Conventional biochemical and molecular biological approaches have been widely used to analyze glutamate receptor trafficking, especially for α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate-type glutamate receptors (AMPARs). However, conflicting findings have been reported because of a lack of useful tools for analyzing endogenous AMPARs. Here, we develop a method for the rapid and selective labeling of AMPARs with chemical probes, by combining affinity-based protein labeling and bioorthogonal click chemistry under physiological temperature in culture medium. This method allows us to quantify AMPAR distribution and trafficking, which reveals some unique features of AMPARs, such as a long lifetime and a rapid recycling in neurons. This method is also successfully expanded to selectively label N-methyl-D-aspartate-type glutamate receptors. Thus, bioorthogonal two-step labeling may be a versatile tool for investigating the physiological and pathophysiological roles of glutamate receptors in neurons.

scholarly journals Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression

2005 ◽  
Vol 280 (17) ◽  
pp. 16962-16968 ◽  
Author(s):  
Eric M. Snyder ◽  
Marcie Colledge ◽  
Robert A. Crozier ◽  
Wendy S. Chen ◽  
John D. Scott ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Synaptic Depression ◽  
Receptor Trafficking ◽  
Anchoring Proteins ◽  
Glutamate Receptor Trafficking

scholarly journals Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha

2019 ◽  
Vol 39 (17) ◽  
pp. 3188-3203 ◽  
Author(s):  
Bruce G. Mockett ◽  
Diane Guévremont ◽  
Megan K. Elder ◽  
Karen D. Parfitt ◽  
Katie Peppercorn ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Amyloid Precursor Protein ◽  
Glutamate Receptor ◽  
Receptor Trafficking ◽  
Precursor Protein ◽  
Glutamate Receptor Trafficking

Glutamate Receptor Trafficking in Synaptic Plasticity

2002 ◽  
Vol 2002 (156) ◽  
pp. re14-re14 ◽  
Author(s):  
A. Contractor ◽  
S. F. Heinemann
Keyword(s):  
Synaptic Plasticity ◽  
Glutamate Receptor ◽  
Receptor Trafficking ◽  
Glutamate Receptor Trafficking
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