The Isolated Perfused Lung for Drug Absorption Studies

2007 ◽  
pp. 135-163 ◽  
Author(s):  
Ann Tronde ◽  
Cynthia Bosquillon ◽  
Ben Forbes
Keyword(s):  
Drug Absorption ◽  
Isolated Perfused Lung ◽  
Absorption Studies ◽  
Perfused Lung

The Effect of Tumor Necrosis Factor-?? on Microvascular Permeability in an Isolated, Perfused Lung

Shock ◽  
2002 ◽  
Vol 18 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Carl I. Schulman ◽  
Joseph K. Wright ◽  
Fiemu Nwariaku ◽  
George Sarosi ◽  
Richard H. Turnage
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Microvascular Permeability ◽  
Isolated Perfused Lung ◽  
Perfused Lung ◽  
Necrosis Factor

Effect of small doses of 5-hydroxytryptamine (serotonin) on pulmonary circulation in the closed-chest dog

1959 ◽  
Vol 197 (5) ◽  
pp. 963-967 ◽  
Author(s):  
John T. Shepherd ◽  
David E. Donald ◽  
Erland Linder ◽  
H. J. C. Swan
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Blood Flow ◽  
Pulmonary Veins ◽  
Pulmonary Vessels ◽  
Isolated Perfused Lung ◽  
Small Doses ◽  
Perfused Lung ◽  
Anesthetized Dogs ◽  
Flow Through ◽  
The Difference

5-Hydroxytryptamine (serotonin) was infused into anesthetized dogs at a rate of 20 µg/kg/min. In nine sets of observations on three dogs the increase in the difference of pressure between the pulmonary artery and the left atrium, which averaged 55%, consistently exceeded the increase in pulmonary blood flow, which averaged 16%. 5-HT therefore is a potent constrictor of pulmonary vessels, even in small concentrations. No changes in the pulmonary-artery wedge and pulmonary-vein pressures were detected during the infusions of 5-HT, nor was there any change in the volume of blood between the pulmonary artery and the root of the aorta. With this dose of 5-HT the principal site of the increased resistance to flow through the lungs appeared to be in the precapillary vessels. In the isolated perfused lung, moderate constriction of pulmonary veins also was produced by large doses of 5-HT.

Use of Rabbits for GI Drug Absorption Studies

1977 ◽  
Vol 66 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Tadao Maeda ◽  
Hiroshi Takenaka ◽  
Yoshiya Yamahira ◽  
Takeshi Noguchi
Keyword(s):  
Drug Absorption ◽  
Absorption Studies
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